%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 113 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.81900024 23.67700005 Tm 0 g [(C2CD)-1(2)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.7769928 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.48098755 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(C2CD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 86.0510025 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.05099487 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(C2CD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.8010025 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.17500305 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.3769989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.75099945 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.73100281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.10499573 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.57899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [(C2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.41999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.79399872 12.82499981 Tm [(calci)-1(um-depend)-1(e)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.41499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.78900146 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.18600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.55999756 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.39500427 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.76899719 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.8999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.27400208 12.82499981 Tm [(TME)-1(M2)1(4L)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.33999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.71398926 12.82499981 Tm [(C21orf25;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.81100464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.18499756 12.82499981 Tm [(C21orf258)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.79501343 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 30.76399994 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 30.76399994 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 254.772995 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(189-3)1(88)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(C2CD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.06399536 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 339.58999634 m 416.75 339.58999634 l 416.75 370.79000854 l -1.45000005 370.79000854 l h f* Q q 1 0 0 1 0 339.58999634 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 370.79000854 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 398.72900391 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29800034 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79800034 11.72200012 Tm [(calc)-1(ium-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.48699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.98699951 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.81399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.31399536 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.56100464 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.83900452 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TMEM2)-1(4L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.03499985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.53499985 11.72200012 Tm [(C21)-1(or)1(f25)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.11199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.61199951 11.72200012 Tm [(C21)-1(or)1(f25)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.30000305 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9Y42)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.8769989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(62)-1(32)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 116.42500305 16.35000038 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 115.67500305 0.75 l 115.67500305 47.54999924 l 0.375 47.54999924 l h f* Q q -0.625 -0.25 m 116.67500305 -0.25 l 116.67500305 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 27.3220005 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.42500305 0.75 m 426.17498779 0.75 l 426.17498779 47.54999924 l 116.42500305 47.54999924 l h f* Q q 1 0 0 1 116.05000305 0 cm -0.625 -0.25 m 311.125 -0.25 l 311.125 48.54999924 l -0.625 48.54999924 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C2CD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.45199966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.95199966 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.51300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.01300049 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.5340004 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.0340004 11.72200012 Tm [(69)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.86699677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.36699677 11.72200012 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.43699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.93699646 11.72200012 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.57699585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.07699585 11.72200012 Tm [(pro)1(tien)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.38400269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.88400269 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.10600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.60600281 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.16700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.66700745 11.72200012 Tm [(sec)-1(reted.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.37800598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.87800598 11.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.68499756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.18499756 11.72200012 Tm [(C2CD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.63699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 27.3220005 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.0909996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.59100342 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.27300262 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.77300262 27.3220005 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.27999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.77999878 27.3220005 Tm [(pro)1(visionally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.16200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.66200256 27.3220005 Tm [(designat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.58000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.08000183 27.3220005 Tm [(C2CD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.53199768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.03199768 27.3220005 Tm [(pending)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.88699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.38699341 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(urth)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.42000008 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.92000008 42.92200089 Tm [(chara)1(c)-1(teriza)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.74700165 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 0.75 m 116.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 17.10000038 m 116.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 33.45000076 m 116.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 49.80000305 m 116.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 66.15000153 m 116.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 82.5 m 116.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 98.84999847 m 116.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.05000305 115.19999695 m 116.05000305 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 162 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 162.375 m 426.92498779 162.375 l S Q Q q 1 0 0 1 0 561.47900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 589.41802979 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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