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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 66.25299835 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 138.01699829 23.67700005 Tm 0 Tr [(THUMPD1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 238.60699463 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 349.04699707 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(THUMPD1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 141.88900757 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 194.38900757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.63900757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.56000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(THUMP)1(D1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.31199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.68600464 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.45799255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.83200073 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.15299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.5269928 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.32299805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DKFZp)-1(686)1(C)-1(1)1(054)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.02400208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(THUMPD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.57900238 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14100647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.51499939 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.13499451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.50900269 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.8710022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 113.92500305 0.75 l 113.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 114.92500305 -0.25 l 114.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 114.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 114.67500305 172.3500061 l h f* Q q 1 0 0 1 114.30000305 0 cm -0.625 -0.25 m 309.125 -0.25 l 309.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(TH)-1(U)1(MP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.44599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.94599915 11.72200012 Tm [(\(af)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.94300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.44300079 11.72200012 Tm [(th)1(iouridine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.63600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.13600159 11.72200012 Tm [(syntha)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.08599854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.58599854 11.72200012 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.11099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.61099243 11.72200012 Tm [(methylases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.61700439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.11700439 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.39401245 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.89401245 11.72200012 Tm [(pse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(udourid)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.20600128 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.70600128 27.3220005 Tm [(syntha)1(se)-1(s\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.49500275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.99500275 27.3220005 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.82200623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.32200623 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.88299561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.38299561 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.90400696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.40400696 27.3220005 Tm [(anci)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.83799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.33799744 27.3220005 Tm [(10)-1(0-11)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.89900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.39900208 27.3220005 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.46899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.96899414 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.60900879 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.02300072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.52300072 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.74499893 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.24499893 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.80599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.30599976 42.92200089 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.9960022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.4960022 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.43699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.93699646 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.41000366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.91000366 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.13200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.63200378 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.1499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.6499939 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.01899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.51899719 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.46000671 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.96000671 42.92200089 Tm [(RNA)1(-mod)1(i)-1(f)1(ic)-1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 58.52199936 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.95700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.45700073 58.52199936 Tm [(TH)-1(U)1(MP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.59600067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.09600067 58.52199936 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.08900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.58900452 58.52199936 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.63800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.13800049 58.52199936 Tm [(RNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.69999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.19999695 58.52199936 Tm [(seque)-1(nce)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.2130127 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.7130127 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.32099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.82099915 74.12200165 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.63400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.13400269 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.20899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.70899963 74.12200165 Tm [(delive)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.6289978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.1289978 74.12200165 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.65400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.15400696 74.12200165 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.47900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.97900391 74.12200165 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.52600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.02600098 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.10099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.60101318 74.12200165 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.43399048 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.93399048 74.12200165 Tm [(ta)1(rg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.45899963 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.95899963 89.72200012 Tm [(subst)1(rat)1(e)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.14099884 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.64099884 89.72200012 Tm [(TH)-1(U)1(MPD1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.08000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58000183 89.72200012 Tm [(TH)-1(U)1(MPD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.852005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.352005 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.6289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.1289978 89.72200012 Tm [(TH)-1(U)1(MD3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.89500427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.39500427 89.72200012 Tm [(\(TH)-1(U)1(MP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.54000854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.04000854 89.72200012 Tm [(do)1(mai)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(n-containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.18700027 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.68700027 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.9940033 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.4940033 105.3219986 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.93800354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.43800354 105.3219986 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.71600342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.21600342 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.49299622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.99299622 105.3219986 Tm [(3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.43699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.93699646 105.3219986 Tm [(respec)-1(t)1(ive)-1(ly\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.75700378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.25700378 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.7749939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.2749939 105.3219986 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.70498657 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.20498657 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.04699707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.54699707 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.54800415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.97899628 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47899628 120.92199707 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.56300354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.06300354 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.33999634 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.83999634 120.92199707 Tm [(eac)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.97599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.47599792 120.92199707 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.5249939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.0249939 120.92199707 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.39900208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.89900208 120.92199707 Tm [(TH)-1(U)1(MP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.03799438 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.53799438 120.92199707 Tm [(do)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ain.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.08199978 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.58200073 136.52200317 Tm [(Both)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.84500122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.34500122 136.52200317 Tm [(TH)-1(U)1(MPD2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.61699677 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.11699677 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.39399719 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.89399719 136.52200317 Tm [(TH)-1(U)1(MPD3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.16600037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.66600037 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.18400574 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.68400574 136.52200317 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.83799744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.33799744 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.27900696 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.77900696 136.52200317 Tm [(tiss)1(u)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.67700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.17700195 136.52200317 Tm [(th)1(rou)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(gh)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.91900063 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.41900063 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.41999817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.91999817 152.12199402 Tm [(bo)1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.91000366 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.41000366 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.80599976 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.30599976 152.12199402 Tm [(hig)1(he)-1(s)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.16600037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.66600037 152.12199402 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.61999512 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.11999512 152.12199402 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.01300049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.51300049 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.45399475 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.95399475 152.12199402 Tm [(ske)-1(leta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.3500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.8500061 152.12199402 Tm [(musc)-1(le,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.17599487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(spleen)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.23399925 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.73400116 167.72200012 Tm [(th)1(y)-1(mus,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.70400238 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.20400238 167.72200012 Tm [(live)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.26100159 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.76100159 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.03800201 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.53800201 167.72200012 Tm [(ki)-1(d)1(ne)-1(y.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.17199707 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.67199707 167.72200012 Tm [(Due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.17999268 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.67999268 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.75500488 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.25500488 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.2559967 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.7559967 167.72200012 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.48500061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.98500061 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.82699585 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.32699585 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.30200195 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.80200195 167.72200012 Tm [(TH)-1(U)1(M)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 114.30000305 0.75 m 114.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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