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0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TGM2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 125.79000092 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.28999329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 183.53999329 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TGM2)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 109.77300262 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 112.14700317 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 140.91900635 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 143.29299927 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 193.61399841 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 195.98800659 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 233.78399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transglu)-1(tam)1(i)-1(nase)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 136.91999817 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 139.29400635 12.82499981 Tm [(2;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 147.42500305 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 149.79899597 12.82499981 Tm [(TGC;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 169.94799805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 172.32200623 12.82499981 Tm [(TG\(C)-1(\))] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 196.02900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001C000E>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TGM2)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 89.04000092 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 78 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 81 >> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 109.42500305 141.1499939 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 84 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Transglut)1(amin)-1(a)1(se)-1(s)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 80.09500122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 84.59500122 11.72200012 Tm [(are)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 98.11299896 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 102.61299896 11.72200012 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 140.16000366 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 144.66000366 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 161.88200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 166.38200378 11.72200012 Tm [(cata)1(l)-1(yze)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 200.88800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 205.38800049 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 219.38900757 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 223.88900757 11.72200012 Tm [(crosslink)-1(ing)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 274.82598877 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 279.32598877 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 288.16799927 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 292.66799927 11.72200012 Tm [(pr)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(e)-1(ins)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 26.28800011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 30.78800011 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 41.29999924 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 45.79999924 27.3220005 Tm [(epsilon-g)1(amma)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 113.34400177 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 117.84400177 27.3220005 Tm [(gluta)1(my)-1(l)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 155.46099854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 159.96099854 27.3220005 Tm [(lysin)-1(e)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 184.33299255 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 188.83299255 27.3220005 Tm [(isop)1(e)-1(p)1(tide)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 234.33000183 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 238.83000183 27.3220005 Tm [(bo)1(n)-1(d)1(s.)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 267.93499756 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 272.43499756 27.3220005 Tm [(Wh)1(il)-1(e)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 297.03100586 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 301.53100586 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(he)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 10.64799976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 15.14799976 42.92200089 Tm [(prima)1(ry)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 48.33599854 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 52.83599854 42.92200089 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 91.29299927 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 95.79299927 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 104.63500214 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 109.13500214 42.92200089 Tm [(tr)1(ansgluta)1(m)-1(inas)1(e)-1(s)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 187.42399597 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 191.92399597 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 198.48500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 202.98500061 42.92200089 Tm [(not)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 217.60600281 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 222.10600281 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)1(,)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 268.3500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 272.8500061 42.92200089 Tm [(th)1(e)-1(y)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 291.61499023 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 296.11499023 42.92200089 Tm [(all)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 305.88000488 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 20.34700012 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 24.84700012 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 38.84799957 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 43.34799957 58.52199936 Tm [(same)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 66.02799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 70.52799988 58.52199936 Tm [(amino)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 97.59799957 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 102.09799957 58.52199936 Tm [(acid)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 119.73799896 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 124.23799896 58.52199936 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 165.08500671 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 169.58500671 58.52199936 Tm [(at)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 177.91299438 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 182.41299438 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 202.2460022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 206.7460022 58.52199936 Tm [(active)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 231.81199646 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 236.31199646 58.52199936 Tm [(sites)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 255.49899292 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 259.99899292 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 276.27600098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 280.77600098 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 300.60900879 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 30.47200012 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 34.97200012 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 41.53300095 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 46.03300095 74.12200165 Tm [(calc)-1(ium-d)1(e)-1(p)1(e)-1(ndent.)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 131.88900757 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 136.38900757 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 152.19599915 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 156.69599915 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 188.00300598 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 192.50300598 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 230.00999451 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 234.50999451 74.12200165 Tm [(by)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 245.02200317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 249.52200317 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 264.97799683 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 269.47799683 74.12200165 Tm [(gene)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 290.99398804 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 295.49398804 74.12200165 Tm [(ac)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ts)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 7.51900005 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 12.01900005 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 21.15999985 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 25.65999985 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 30.63500023 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 35.13499832 89.72200012 Tm [(monomer,)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 79.69999695 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 84.19999695 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 90.76100159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 95.26100159 89.72200012 Tm [(induc)-1(ed)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 129.8809967 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 134.3809967 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 144.89300537 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 149.39300537 89.72200012 Tm [(retinoic)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 181.86000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 186.36000061 89.72200012 Tm [(acid,)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 206.16600037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 210.66600037 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 226.94299316 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 231.44299316 89.72200012 Tm [(ap)1(pears)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 265.59698486 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 270.09698486 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 279.17199707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 283.67199707 89.72200012 Tm [(be)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 294.52600098 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 299.02600098 89.72200012 Tm [(i)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nvolved)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 33.97399902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 38.47399902 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 46.41500092 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 50.91500092 105.3219986 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 95.0759964 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 99.5759964 105.3219986 Tm [(Fin)-1(a)1(ll)-1(y,)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 128.99299622 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 133.49299622 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 147.4940033 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 151.9940033 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 189.50100708 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 194.00100708 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 225.30799866 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 229.80799866 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 236.3690033 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 240.8690033 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 254.86999512 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 259.36999512 105.3219986 Tm [(auto)1(antige)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(n)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 5.546 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 10.04599953 120.92199707 Tm [(implicated)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 55.11600113 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 59.61600113 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 67.55699921 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 72.05699921 120.92199707 Tm [(ce)-1(liac)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 95.95400238 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 100.45400238 120.92199707 Tm [(disease.)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 134.29200745 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 138.79200745 120.92199707 Tm [(Two)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 156.77900696 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 161.27900696 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 202.20100403 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 206.70100403 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 240.27099609 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 244.77099609 120.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 285.11300659 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 289.61300659 120.92199707 Tm [(dif)1(f)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ere)-1(nt)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 22.54800034 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 27.04800034 136.52200317 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 64.20800018 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 68.70800018 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 89.05500031 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 93.55500031 136.52200317 Tm [(been)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 115.06199646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 119.56199646 136.52200317 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 145.2519989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 149.7519989 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 162.02999878 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 166.52999878 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 181.98599243 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 186.48599243 136.52200317 Tm [(gene)-1(.)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 210.16799927 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 262 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 263 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 264 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 108.67500305 0.75 l 108.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 109.67500305 -0.25 l 109.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 268 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 273 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 109.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 109.42500305 16.35000038 l h f* Q q 1 0 0 1 109.05000305 0 cm -0.625 -0.25 m 314.375 -0.25 l 314.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 274 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TGM2)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 25.92300034 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 0.75 m 109.05000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 141.8999939 m 109.05000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 109.05000305 158.25 m 109.05000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17498779 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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