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g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TGF)-1(B1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 127.34799957 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.8480072 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 195.5980072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TGFB1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 111.33200073 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 113.70600128 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 142.47799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 144.852005 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 195.17300415 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 197.54699707 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 235.34300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transfo)-1(r)1(mi)-1(ng)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 118.48899841 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 122.84300232 12.82499981 Tm [(gr)1(o)-1(wt)1(h)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 153.522995 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 157.8769989 12.82499981 Tm [(factor)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 183.26600647 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 187.61999512 12.82499981 Tm [(beta)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 206.90800476 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 211.26199341 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 219.39300537 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 223.74699402 12.82499981 Tm [(CED)-1(;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 243.74200439 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 248.09599304 12.82499981 Tm [(LAP;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 266.82000732 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 271.17401123 12.82499981 Tm [(DPD1;)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 297.6499939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 302.0039978 12.82499981 Tm [(TGF)-1(B;)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 327.08999634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 331.44400024 12.82499981 Tm [(IBDIMDE)-1(;)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 372.27999878 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 376.63400269 12.82499981 Tm [(TGF)-1(beta;)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 415.29598999 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(TGF)-1(-beta1)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 44.38899994 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TGF)-1(B1)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 90.59799957 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002300240025000E>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <</MCID 92 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 93 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <</MCID 95 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 128.17500305 0.75 l 128.17500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 129.17500305 -0.25 l 129.17500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 97 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.92500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 128.92500305 156.75 l h f* Q q 1 0 0 1 128.55000305 0 cm -0.625 -0.25 m 294.875 -0.25 l 294.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(sec)-1(reted)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 134.21499634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 138.71499634 11.72200012 Tm [(ligand)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 165.53900146 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 170.03900146 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 178.8809967 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 183.3809967 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 197.38200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 201.88200378 11.72200012 Tm [(TGF-b)1(e)-1(t)1(a)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 241.59100342 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 246.09100342 11.72200012 Tm [(\(tr)1(ansfor)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ming)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 22.13100052 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 26.63100052 27.3220005 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 57.54700089 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 62.04700089 27.3220005 Tm [(fa)1(c)-1(t)1(or-b)1(e)-1(t)1(a\))] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 113.2480011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 117.7480011 27.3220005 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 167.83200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 172.33200073 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 181.17399597 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 185.67399597 27.3220005 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 223.31300354 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 227.81300354 27.3220005 Tm [(Ligands)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 261.02700806 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 265.52700806 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 274.36898804 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 278.86898804 27.3220005 Tm [(t)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(his)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 12.10299969 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 16.60300064 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 42.68500137 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 47.18500137 42.92200089 Tm [(bind)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 66.6309967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 71.1309967 42.92200089 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 102.09500122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 106.59500122 42.92200089 Tm [(TGF-b)1(e)-1(t)1(a)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 146.30400085 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 150.80400085 42.92200089 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 191.39199829 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 195.89199829 42.92200089 Tm [(leading)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 227.82299805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 232.32299805 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 241.397995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 245.897995 42.92200089 Tm [(rec)-1(ruit)1(m)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(en)-1(t)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 14.00500011 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 18.50499916 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 34.7820015 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 39.2820015 58.52199936 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 81.23200226 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 85.73200226 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 94.5739975 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 99.0739975 58.52199936 Tm [(SMAD)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 126.25 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 130.75 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 156.83200073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 161.33200073 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 215.91600037 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 220.41600037 58.52199936 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 249.70100403 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 254.20100403 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 271.42300415 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 275.92300415 58.52199936 Tm [(re)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(gulat)1(e)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 27.13199997 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 31.63199997 74.12200165 Tm [(gene)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 53.14799881 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 57.64799881 74.12200165 Tm [(expression.)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 105.76799774 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 110.26799774 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 126.07499695 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 130.57499695 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 168.08200073 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 172.58200073 74.12200165 Tm [(prepr)1(opro)1(tein)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 233.08599854 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 237.58599854 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 244.14700317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 248.64700317 74.12200165 Tm [(pro)1(teoly)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(tically)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 24.79000092 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 29.29000092 89.72200012 Tm [(pro)1(c)-1(essed)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 73.01100159 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 77.51100159 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 86.58599854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 91.08599854 89.72200012 Tm [(gene)-1(r)1(ate)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 129.47200012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 133.97200012 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 138.94700623 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 143.44700623 89.72200012 Tm [(lat)1(e)-1(ncy)-1(-)1(associated)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 223.11999512 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 227.61999512 89.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 260.83401489 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 265.33401489 89.72200012 Tm [(\(LAP)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(\))] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 3.00600004 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 7.50600004 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 23.78300095 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 28.28300095 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 33.25799942 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 37.75799942 105.3219986 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 68.60800171 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 73.10800171 105.3219986 Tm [(pept)1(ide,)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 108.48799896 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 112.98799896 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 129.26499939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 133.76499939 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 140.32600403 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 144.82600403 105.3219986 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 170.51600647 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 175.01600647 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 182.95700073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 187.45700073 105.3219986 Tm [(either)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 212.39599609 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 216.89599609 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 221.8710022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 226.3710022 105.3219986 Tm [(lat)1(e)-1(nt)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 251.09899902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 255.59899902 105.3219986 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 276.30999756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 280.80999756 105.3219986 Tm [(c)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(omp)1(osed)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 40.65399933 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 45.15399933 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 53.99599838 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 58.49599838 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 63.47100067 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 67.97100067 120.92199707 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 98.82099915 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 103.32099915 120.92199707 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 136.53500366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 141.03500366 120.92199707 Tm [(ho)1(modimer,)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 193.74699402 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 198.24699402 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 203.22200012 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 207.72200012 120.92199707 Tm [(LAP)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 224.17999268 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 228.67999268 120.92199707 Tm [(ho)1(modimer,)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 281.39199829 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 16.27700043 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 20.77700043 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 25.75200081 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 30.25200081 136.52200317 Tm [(lat)1(e)-1(nt)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 54.97999954 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 59.47999954 136.52200317 Tm [(TGF-b)1(e)-1(t)1(a)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 99.18900299 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 103.68900299 136.52200317 Tm [(binding)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 136.83299255 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 141.33299255 136.52200317 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 174.80599976 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 179.30599976 136.52200317 Tm [(or)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 188.46400452 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 192.96400452 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 200.90499878 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 205.40499878 136.52200317 Tm [(an)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 215.92599487 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 220.42599487 136.52200317 Tm [(active)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 245.49200439 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 249.99200439 136.52200317 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 270.70300293 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 275.20300293 136.52200317 Tm [(co)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nsisting)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 33.32400131 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 37.82400131 152.12199402 Tm [(solely)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 62.37200165 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 66.87200165 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 75.71399689 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 80.21399689 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 94.21499634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 98.71499634 152.12199402 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 129.56500244 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 134.06500244 152.12199402 Tm [(pept)1(ide)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 167.27900696 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 171.77900696 152.12199402 Tm [(ho)1(modimer.)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 224.49099731 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 228.99099731 152.12199402 Tm [(The)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 244.79800415 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 249.29800415 152.12199402 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 280.14801025 152.12199402 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 128.55000305 0.75 m 128.55000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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6 0 obj
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