%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 148 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 103.3030014 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 175.06700134 23.67700005 Tm 0 Tr [(TF)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 201.55700684 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 311.99700928 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TF)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 109.69100189 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 162.19099426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.94099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.67500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.0490036 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.82099915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.19499969 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.51600647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.68600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transfer)1(ri)-1(n;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.31600189 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.69000244 12.82499981 Tm [(TF)-1(QTL1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.73199463 12.82499981 Tm [(PRO15)1(57;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.90600586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.27999878 12.82499981 Tm [(PRO20)1(86;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.45399475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.82800293 12.82499981 Tm [(HEL)-1(-S-)-1(7)1(1p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.32501221 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.94100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 116.17500305 0.75 l 116.17500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 117.17500305 -0.25 l 117.17500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.92500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 116.92500305 156.75 l h f* Q q 1 0 0 1 116.55000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(glyc)-1(o)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.1269989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.6269989 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.022995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.522995 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.04400635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.54400635 11.72200012 Tm [(ap)1(prox)1(i)-1(ma)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.99699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.49699402 11.72200012 Tm [(molec)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.01800537 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(weigh)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.25900078 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.75899887 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.60100174 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.10100174 27.3220005 Tm [(76)-1(.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.10099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.60099792 27.3220005 Tm [(kDa.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.49700165 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.99700165 27.3220005 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.4960022 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.05699921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.55699921 27.3220005 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.36999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.86999512 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.94500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.44500732 27.3220005 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.79200745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.29200745 27.3220005 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.79899597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.29899597 27.3220005 Tm [(cre)-1(a)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.54600525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.04600525 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.18701172 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.68701172 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.6619873 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.1619873 27.3220005 Tm [(resu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.74800014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.24800014 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.09000015 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.59000015 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.11100006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61100006 42.92200089 Tm [(anci)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.04499817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.54499817 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.06099701 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.56099701 42.92200089 Tm [(duplicatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.90499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.40499878 42.92200089 Tm [(eve)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.24099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.74099731 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.96299744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.46299744 42.92200089 Tm [(led)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.72099304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.22099304 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.29600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.79600525 42.92200089 Tm [(gene)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.73800659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.23800659 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.07998657 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ho)1(mologo)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.72499847 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.22499847 58.52199936 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.2460022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.7460022 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.02300262 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.52300262 58.52199936 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.3730011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.8730011 58.52199936 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.86599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.36599731 58.52199936 Tm [(eac)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.5019989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.0019989 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.84399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.34399414 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.44099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.94099426 58.52199936 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.55300903 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.05300903 58.52199936 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.42700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.00499916 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.50499916 74.12200165 Tm [(ferric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.51300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.01300049 74.12200165 Tm [(iron.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.27899933 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.77899933 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.58599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.08599854 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.82699585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.32699585 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.16900635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.66900635 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.125 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.625 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.93200684 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.43200684 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.99299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.49299622 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.56799316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.06799316 74.12200165 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.80300903 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.30300903 74.12200165 Tm [(iron)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.40200806 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.71100044 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.21100044 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.2120018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.7120018 89.72200012 Tm [(intestine,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.84500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.34500122 89.72200012 Tm [(reticu)-1(lo)1(e)-1(ndo)1(thelial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.10299683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.60299683 89.72200012 Tm [(system,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.75799561 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.25799561 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.53500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.03500366 89.72200012 Tm [(live)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.09199524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.59199524 89.72200012 Tm [(pa)1(re)-1(nchy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(mal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.3029995 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.87900162 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.37900162 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.45399857 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.95399857 105.3219986 Tm [(all)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.71900177 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.21900177 105.3219986 Tm [(pro)1(life)-1(r)1(ating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.60399628 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.10400391 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.67999268 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.17999268 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.1210022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.6210022 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.62199402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.12199402 105.3219986 Tm [(bo)1(dy.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.27900696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.77900696 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.04100037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.54100037 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.84799194 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.34799194 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.51901245 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.01901245 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(lso)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.28299999 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.78300095 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.13000107 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.63000107 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.60499954 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.10499954 120.92199707 Tm [(ph)1(y)-1(sio)1(l)-1(o)1(gic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.22299957 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.72299957 120.92199707 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.38300323 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.88300323 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.02400208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.52400208 120.92199707 Tm [(gr)1(anu)-1(lo)1(c)-1(yte/pollen)-1(-)1(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.43099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.93099976 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.23800659 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(\(GP)1(B)-1(P\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.36400032 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.86399841 136.52200317 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.23300171 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.73300171 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.6740036 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.1740036 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.17500305 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.67500305 136.52200317 Tm [(removal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.46699524 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.96699524 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80900574 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.30900574 136.52200317 Tm [(ce)-1(rt)1(ain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.63400269 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.13400269 136.52200317 Tm [(org)1(anic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.47799683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.97799683 136.52200317 Tm [(mat)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.63500977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.13500977 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.4119873 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.9119873 136.52200317 Tm [(alle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(rg)1(e)-1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.01199913 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.51199913 152.12199402 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.22299957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.72299957 152.12199402 Tm [(serum.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.57700348 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 116.17500305 0.75 l 116.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 117.17500305 -0.25 l 117.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 116.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 116.92500305 16.35000038 l h f* Q q 1 0 0 1 116.55000305 0 cm -0.625 -0.25 m 306.875 -0.25 l 306.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.55000305 0.75 m 116.55000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 116.55000305 157.5 m 116.55000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>