%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 124 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.98799896 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 161.7519989 23.67700005 Tm 0 Tr [(TDP)-1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.87199402 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 325.31201172 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TD)-1(P)1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.07299805 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.57299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.07299805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TDP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.05599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.43000031 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.20199585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.57600403 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.89700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.27099609 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.06700134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tyr)1(o)-1(sy)1(l)-1(-DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.26399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.63800049 12.82499981 Tm [(ph)-1(osp)-1(hod)-1(ieste)1(rase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.90499878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.27900696 12.82499981 Tm [(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.41000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.78399658 12.82499981 Tm [(EAP)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.54200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.91600037 12.82499981 Tm [(AD022)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.22601318 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.6000061 12.82499981 Tm [(EAP)1(II;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.32699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.70098877 12.82499981 Tm [(TT)-1(RA)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.94500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.31900024 12.82499981 Tm [(hT)-1(DP2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 361.96798706 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 364.3420105 12.82499981 Tm [(dJ30M3.3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 406.12200928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TD)-1(P)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.32299805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 153.67500305 0.75 l 153.67500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 154.67500305 -0.25 l 154.67500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.42500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 154.42500305 125.55000305 l h f* Q q 1 0 0 1 154.05000305 0 cm -0.625 -0.25 m 269.375 -0.25 l 269.375 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.25100708 11.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.33500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.83500671 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.67700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.17700195 11.72200012 Tm [(diva)1(l)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 27.3220005 Tm [(cation-)1(depe)-1(nd)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.27600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.77600098 27.3220005 Tm [(ph)1(osph)1(odiesterases.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.86399841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.36399841 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.17100525 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.67100525 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.17799377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.67799377 27.3220005 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.39999962 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.43699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.93699646 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.33300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.83300018 42.92200089 Tm [(CD40)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.43099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.93099976 42.92200089 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.42100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.92100525 42.92200089 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.97200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.47200012 42.92200089 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.59100342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.09100342 42.92200089 Tm [(\(TNF\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.36000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.86000061 42.92200089 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ce)-1(pt)1(or-)1(7)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.32799911 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.82799911 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.10499954 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.60500336 58.52199936 Tm [(TNF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.86199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.36199951 58.52199936 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.78399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.28399658 58.52199936 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.41099548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.91099548 58.52199936 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.19599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.69599915 58.52199936 Tm [(\(TRAFs\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.18899536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.68899536 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 74.12200165 Tm [(inhibits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.3429985 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.8429985 74.12200165 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.36100006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.86100006 74.12200165 Tm [(fa)1(c)-1(t)1(or-kap)1(pa-)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.75900269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.25900269 74.12200165 Tm [(activat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.37600708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.87600708 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.13800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.63800049 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.94500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.68200016 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18199921 89.72200012 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.02899933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.52899933 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.80599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.30599976 89.72200012 Tm [(st)1(ruc)-1(tura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.02600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.52600098 89.72200012 Tm [(similarit)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.13699341 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.63699341 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.03300476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.53300476 89.72200012 Tm [(AP)1(E1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.5980072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.0980072 89.72200012 Tm [(en)-1(d)1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(uc)-1(lease,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.97399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.47399902 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.57099915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.07099915 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63200378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.13200378 105.3219986 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.50099945 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.00099945 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.94200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44200134 105.3219986 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.80599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.30599976 105.3219986 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.81100464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.31100464 105.3219986 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.40800476 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.90800476 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.18499756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.68499756 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.68600464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.18600464 105.3219986 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tiva)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.4620018 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.9620018 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.80400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.30400085 120.92199707 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.88800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.38800049 120.92199707 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.83999634 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 153.67500305 0.75 l 153.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.67500305 -0.25 l 154.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.42500305 16.35000038 l h f* Q q 1 0 0 1 154.05000305 0 cm -0.625 -0.25 m 269.375 -0.25 l 269.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 153.67500305 0.75 l 153.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.67500305 -0.25 l 154.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.42500305 16.35000038 l h f* Q q 1 0 0 1 154.05000305 0 cm -0.625 -0.25 m 269.375 -0.25 l 269.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TDP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.79899979 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 153.67500305 0.75 l 153.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 154.67500305 -0.25 l 154.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.42500305 16.35000038 l h f* Q q 1 0 0 1 154.05000305 0 cm -0.625 -0.25 m 269.375 -0.25 l 269.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TDP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.14500427 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.05000305 0.75 m 154.05000305 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.05000305 126.30000305 m 154.05000305 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.05000305 142.65000916 m 154.05000305 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.05000305 159.00001526 m 154.05000305 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>