%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 138 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 72.70400238 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 144.46800232 23.67700005 Tm 0 Tr [(TBC1D13)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 232.15600586 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 342.5960083 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(TBC1D)-1(1)1(3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 136.16200256 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.66200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.91200256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TBC1D13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.58499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.95899963 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.73100281 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.10499573 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.42599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.80000305 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.59599304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RP1)1(1-545E17.5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.69200134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TBC1D)-1(1)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.85199738 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 142.42500305 172.3500061 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TB)-1(C1D13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.51599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.01599884 11.72200012 Tm [(\(TB)-1(C1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.12599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.62599945 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.45300293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.95300293 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.03500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.53500366 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.79899597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.29899597 11.72200012 Tm [(13)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.86099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.36099243 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.92199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.42199707 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.39700317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.89700317 11.72200012 Tm [(40)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.72999573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.22999573 11.72200012 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.29998779 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.63999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.13999939 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.4469986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.9469986 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.16899872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.66899872 27.3220005 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.88400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.38400269 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.75799561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.25799561 27.3220005 Tm [(Rab)1(-GA)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.28100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.78100586 27.3220005 Tm [(TB)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.60800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.10800171 27.3220005 Tm [(do)1(main.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.102005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.602005 27.3220005 Tm [(Exist)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.39800072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.89800072 42.92200089 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.07899857 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.57899857 42.92200089 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.10199738 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.60199738 42.92200089 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.68299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.18299866 42.92200089 Tm [(isof)1(orms,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.50999451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.00999451 42.92200089 Tm [(TB)-1(C1D13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.52600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.02600098 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.19700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.69700623 42.92200089 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.53799438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.03799438 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.1789856 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 58.52199936 Tm [(GTPa)1(se)-1(-)1(ac)-1(t)1(ivat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.95899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.45899963 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.76599884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.26599884 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.54400635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.04400635 58.52199936 Tm [(Rab)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.64199829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.14199829 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.22399902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.72399902 58.52199936 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.36300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.86300659 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.66999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.17001343 58.52199936 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15200043 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.37400055 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.87400055 74.12200165 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.79100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.29100037 74.12200165 Tm [(TB)-1(C1D13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.80699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.30699921 74.12200165 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.52200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.02200317 74.12200165 Tm [(23)-1(,229)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.57800293 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.07800293 74.12200165 Tm [(ba)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.23899841 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.73899841 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.01600647 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.51600647 74.12200165 Tm [(map)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.8380127 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.61600113 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.11600113 89.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.91100311 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.41100311 89.72200012 Tm [(9q34)-1(.11.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.88999939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.38999939 89.72200012 Tm [(Housin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.48199463 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.98199463 89.72200012 Tm [(over)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.97099304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.47099304 89.72200012 Tm [(90)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.30400085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.80400085 89.72200012 Tm [(gene)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65200806 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.15200806 89.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(hro)1(mosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.2820015 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.7820015 105.3219986 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.06000137 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.55999756 105.3219986 Tm [(comprises)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.2460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.7460022 105.3219986 Tm [(ne)-1(a)1(rly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.96800232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.46800232 105.3219986 Tm [(4%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.75300598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.25300598 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.09500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.59500122 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.59599304 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.09599304 105.3219986 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.13699341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.63699341 105.3219986 Tm [(genome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.47399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(He)-1(redit)1(ary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.29000092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.79000092 120.92199707 Tm [(hemorrh)1(agic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.64700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.14700317 120.92199707 Tm [(telangiec)-1(t)1(asia,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.32299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.82299805 120.92199707 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.91999817 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.41999817 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.98100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.48100281 120.92199707 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.01400757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 136.52200317 Tm [(ha)1(rmful)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.45899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.95899963 136.52200317 Tm [(vascular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68900299 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.18900299 136.52200317 Tm [(defec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.31099701 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.81099701 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.08799744 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.58799744 136.52200317 Tm [(Familial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.33200073 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.83200073 136.52200317 Tm [(dysaut)1(onomia,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.35099792 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.85099792 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.36898804 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.36400032 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.86400032 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.99099731 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.49099731 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.88700104 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.38700104 152.12199402 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.18200684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.68200684 152.12199402 Tm [(9.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.12600708 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.62600708 152.12199402 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.4750061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.9750061 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.91600037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.41600037 152.12199402 Tm [(DFNB3)-1(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.73901367 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.82099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.32099915 167.72200012 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.5890007 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.0890007 167.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.12999725 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.62999725 167.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.42500305 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.92500305 167.72200012 Tm [(9,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.3690033 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.8690033 167.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.38699341 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.88699341 167.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.01400757 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.51400757 167.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.91000366 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.41000366 167.72200012 Tm [(Us)1(he)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>