%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 138 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.42500305 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 160.18899536 23.67700005 Tm 0 Tr [(TANK)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.43499756 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.875 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TAN)1(K)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 123.17500305 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.67500305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.92500305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TAN)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.15799713 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.53199768 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.30400085 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.67799377 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.99899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.3730011 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.16900635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRAF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.71800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.09200287 12.82499981 Tm [(famil)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.28600311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.66000366 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.06100464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.43499756 12.82499981 Tm [(asso)-1(c)1(i)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.352005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.72599792 12.82499981 Tm [(NFKB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.49499512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.8690033 12.82499981 Tm [(activator;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.56201172 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.93600464 12.82499981 Tm [(ITRAF;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.10900879 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.48300171 12.82499981 Tm [(TRAF2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.33200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.70599365 12.82499981 Tm [(I-TRAF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 359.28399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TAN)1(K)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.42500305 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.23400116 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 141.67500305 172.3500061 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(TRAF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.45500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.95500183 11.72200012 Tm [(\(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.4509964 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.9509964 11.72200012 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.0019989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.5019989 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.1210022 11.72200012 Tm [(rec)-1(ept)1(or-)1(associated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.06399536 11.72200012 Tm [(fa)1(c)-1(t)1(or\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.18899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08200073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.58200073 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.42399979 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.92399979 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.39700317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.89700317 27.3220005 Tm [(asso)1(c)-1(iat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.26799774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.76799774 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.16400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.66400146 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94099426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.44099426 27.3220005 Tm [(tr)1(ansduc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.83900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.33900452 27.3220005 Tm [(signals)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.73800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.23800659 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.94900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.43000031 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.93000031 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.77199936 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.27199936 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.27300262 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.77300262 42.92200089 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.26300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.76300049 42.92200089 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.81399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.31399536 42.92200089 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.43299866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.93299866 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.35499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.85499573 42.92200089 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.10598755 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.85600281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.35600281 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.29699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.79699707 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.79800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.29800415 58.52199936 Tm [(cy)-1(t)1(oplas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.43299961 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.93299961 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.20999908 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.70999908 74.12200165 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.74399948 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.24399948 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.69000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.19000244 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.26499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.76499939 74.12200165 Tm [(TRAF1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.35800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.85800171 74.12200165 Tm [(TRAF2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.45100403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.95100403 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.10899353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.60899353 74.12200165 Tm [(TRAF3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.20199585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.70199585 74.12200165 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75799561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.25799561 74.12200165 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69799995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.19799995 89.72200012 Tm [(TRAF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.34600067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.84600067 89.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.58699799 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.08699799 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.59899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.09899902 89.72200012 Tm [(seque)-1(s)1(terin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.53999329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.03999329 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.04100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.54100037 89.72200012 Tm [(TRAFs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.85499573 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.35499573 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.29600525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.79600525 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.77099609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.27099609 89.72200012 Tm [(lat)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.99899292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.49899292 89.72200012 Tm [(st)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.45899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.95899963 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.39999962 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90100098 105.3219986 Tm [(cy)-1(t)1(oplas)1(m.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.13600159 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63600159 105.3219986 Tm [(For)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.57499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.07499695 105.3219986 Tm [(example,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.56700134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.06700134 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.06799316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.56799316 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.875 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.375 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.88200378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.38200378 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.89401245 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39401245 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10299969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60300064 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.11899948 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.61899948 120.92199707 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.65299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.15299988 120.92199707 Tm [(block)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43099976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.93099976 120.92199707 Tm [(TRAF2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.35700226 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.85700226 120.92199707 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.00100708 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.50100708 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.57600403 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.07600403 120.92199707 Tm [(LMP1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.43899536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.93899536 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.94000244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.44000244 120.92199707 Tm [(Ep)1(stein)-1(-)1(B)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 136.52200317 Tm [(virus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.20499992 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.70500183 136.52200317 Tm [(tr)1(ansfor)1(m)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.58999634 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08999634 136.52200317 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.56300354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.06300354 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.33999634 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.83999634 136.52200317 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.21400452 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.71400452 136.52200317 Tm [(LMP1-mediated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.68600464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.18600464 136.52200317 Tm [(NF-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(kappa)1(-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.88600159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.38600159 152.12199402 Tm [(activat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.50299835 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.00299835 152.12199402 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.35299683 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.85299683 152.12199402 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.37600708 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.87600708 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.95700073 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.45700073 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.3789978 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.8789978 152.12199402 Tm [(var)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ants)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54000092 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.88199997 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.38200378 167.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.3219986 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.8219986 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.98199463 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.48199463 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.82899475 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.32899475 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.83599854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.33599854 167.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.02600098 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.52600098 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.80400085 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.30400085 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.76000977 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>