%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 131 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.48699951 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 157.25100708 23.67700005 Tm 0 Tr [(TAF12)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 219.3730011 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 329.81298828 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TAF12)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.41000366 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.91000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.41000366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TAF12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.39399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.76799774 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.53999329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.91400146 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.23500061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.60899353 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.40499878 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TAF12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.66000366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 142.42500305 203.55000305 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cont)1(rol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.69400024 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.5359993 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.0359993 11.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.62000275 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.12000275 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.63200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.13200378 11.72200012 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.65699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.15699768 11.72200012 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.00900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.50900269 11.72200012 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.80000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.30000305 11.72200012 Tm [(involves)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.07800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.57800293 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.57901001 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ba)1(sal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25799942 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.75799942 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.34200287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.84200287 27.3220005 Tm [(machine)-1(r)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.55200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.05200195 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.14900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.64900208 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.21000671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.71000671 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.68499756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.18499756 27.3220005 Tm [(colle)-1(ction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.84500122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.34500122 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.18699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.68699646 27.3220005 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.87800026 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37800026 42.92200089 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.45800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.95800018 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.43099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.93099976 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.32700348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.82700348 42.92200089 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.352005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.852005 42.92200089 Tm [(po)1(l)-1(ymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.70399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.20399475 42.92200089 Tm [(II,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.66200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.16200256 42.92200089 Tm [(assemble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.25799561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.75799561 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.77398682 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.27398682 42.92200089 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(omp)1(l)-1(exes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.23799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.73799896 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.83499908 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.33499908 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.85299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.35299683 58.52199936 Tm [(mod)1(u)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.39599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.89599609 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.40800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.90800476 58.52199936 Tm [(tr)1(ansactivat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.83000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.33000183 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.80300903 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.30300903 58.52199936 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.32800007 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.27399826 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.77399826 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.84899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.34899902 74.12200165 Tm [(ci)-1(s)1(-regulato)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.80699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.30699921 74.12200165 Tm [(ele)-1(ments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.51899719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.01899719 74.12200165 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.83999634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.33999634 74.12200165 Tm [(ad)1(jac)-1(ent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.96800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.46800232 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.54299927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.04299927 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.04400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.54400635 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ranscript)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.23099899 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.73099899 89.72200012 Tm [(st)1(art)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.01399994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.51399994 89.72200012 Tm [(site.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.7009964 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.2009964 89.72200012 Tm [(Some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.65699768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.15699768 89.72200012 Tm [(mod)1(u)-1(la)1(tors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.66099548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.16099548 89.72200012 Tm [(interact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.83900452 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.33900452 89.72200012 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.05900574 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.55899048 89.72200012 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.04299927 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54299927 105.3219986 Tm [(ba)1(sal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.80099869 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.30099869 105.3219986 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.9469986 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.4469986 105.3219986 Tm [(wh)1(e)-1(r)1(e)-1(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.88499451 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.38499451 105.3219986 Tm [(ot)1(hers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.71000671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.21000671 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.3809967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.8809967 105.3219986 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.22200012 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36300659 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.86300659 105.3219986 Tm [(brid)1(ging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.6539917 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.1539917 105.3219986 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(rot)1(e)-1(ins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.72500038 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.22499847 120.92199707 Tm [(link)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.1590004 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.65899658 120.92199707 Tm [(tr)1(ansactivat)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.74699402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.24699402 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.32200623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.82200623 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.82299805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.32299805 120.92199707 Tm [(ba)1(sal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.58099365 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.08099365 120.92199707 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.66499329 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.16499329 120.92199707 Tm [(fa)1(c)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ors)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.49100018 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.99099922 136.52200317 Tm [(Some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.4469986 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.9469986 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.78900146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.28900146 136.52200317 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56199646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.06199646 136.52200317 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.18899536 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.68899536 136.52200317 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.97399902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.47399902 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.99200439 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.49200439 136.52200317 Tm [(weakly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.73800659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.23800659 136.52200317 Tm [(at)1(tached)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.81100464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(wh)1(ile)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54400063 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04400063 152.12199402 Tm [(ot)1(hers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.36899948 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.86899948 152.12199402 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.38700104 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.88700104 152.12199402 Tm [(tig)1(htly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.44499969 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.94499969 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.07200623 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.57200623 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.96800232 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.46800232 152.12199402 Tm [(TB)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.77999878 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.27999878 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.22099304 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.72099304 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.72200012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.22200012 152.12199402 Tm [(TFIID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.30900574 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.80899048 152.12199402 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(mplex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4109993 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9109993 167.72200012 Tm [(Amo)1(n)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.7009964 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.2009964 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.20200348 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.70200348 167.72200012 Tm [(lat)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.32099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.82099915 167.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.33900452 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.83900452 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83999634 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.33999634 167.72200012 Tm [(TAF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.61300659 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.11300659 167.72200012 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.7519989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.2519989 167.72200012 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.29100037 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.79098511 167.72200012 Tm [(TAF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 183.32200623 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.18400002 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.68400002 183.32200623 Tm [(predicted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.85600281 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.35600281 183.32200623 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.43099976 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.93099976 183.32200623 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.05599976 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.55599976 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.55700684 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.05700684 183.32200623 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.79800415 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.29800415 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.13999939 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.63999939 183.32200623 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.11799622 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.61799622 183.32200623 Tm [(tr)1(ansc)-1(rip)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(tio)1(n)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.38500023 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.88500023 198.92199707 Tm [(activat)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.49700165 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.99700165 198.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.27500153 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77500153 198.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.75 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.25 198.92199707 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.00300598 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.50300598 198.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.34500122 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.84500122 198.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.36099243 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.86099243 198.92199707 Tm [(pro)1(moters)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.98399353 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.48399353 198.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.76100159 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.26100159 198.92199707 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.78601074 198.92199707 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>