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gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ST)-1(X18)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 125.78500366 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.28500366 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 183.53500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(STX18)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 109.76799774 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 112.14199829 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 140.91400146 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 143.28799438 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 193.60899353 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 195.98300171 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 233.77900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(syntaxi)-1(n)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 98.39600372 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 100.76999664 12.82499981 Tm [(18;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 114.22299957 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 116.59700012 12.82499981 Tm [(Ufe)1(1)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 137.08399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 31 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 32 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ST)-1(X18)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 89.03500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 76 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 139.42500305 156.75 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(syntaxin)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 205.58299255 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 210.08299255 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 236.16499329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 240.66499329 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 249.50700378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 254.00700378 11.72200012 Tm [(solu)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ble)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 13.25 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 17.75 27.3220005 Tm [(N-eth)1(y)-1(lma)1(l)-1(eimide-sensitive)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 135.96699524 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 140.46699524 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 165.58599854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 170.08599854 27.3220005 Tm [(at)1(tachment)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 219.23399353 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 223.73399353 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 255.04100037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 259.54098511 27.3220005 Tm [(rec)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(epto)1(rs)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 27.53199959 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 32.0320015 42.92200089 Tm [(\(SNARE)1(s\))] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 71.8769989 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 76.3769989 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 101.47399902 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 105.97399902 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 112.53500366 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 117.03500366 42.92200089 Tm [(pa)1(rt)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 134.54699707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 139.04699707 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 147.88900757 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 152.38900757 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 157.36399841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 161.86399841 42.92200089 Tm [(membrane)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 208.647995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 213.147995 42.92200089 Tm [(teth)1(e)-1(r)1(i)-1(ng)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 252.74299622 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 257.24301147 42.92200089 Tm [(com)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(plex)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 17.81100082 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 22.31100082 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 39.53300095 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 44.03300095 58.52199936 Tm [(inc)-1(ludes)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 79.45700073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 83.95700073 58.52199936 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 107.11599731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 111.61599731 58.52199936 Tm [(SNARE)1(s)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 145.44900513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 149.94900513 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 166.22599792 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 170.72599792 58.52199936 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 200.63499451 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 205.13499451 58.52199936 Tm [(periph)1(e)-1(ra)1(l)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 249.022995 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 253.522995 58.52199936 Tm [(mem)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(bra)1(ne)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 24.81200027 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 29.31200027 74.12200165 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 66.9509964 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 71.4509964 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 87.72799683 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 92.22799683 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 98.78900146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 103.28900146 74.12200165 Tm [(involved)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 139.65800476 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 144.15800476 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 152.09899902 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 156.59899902 74.12200165 Tm [(vesic)-1(ular)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 193.85600281 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 198.35600281 74.12200165 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 238.09100342 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 242.59100342 74.12200165 Tm [(betw)1(e)-1(e)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 24.04700089 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 28.54700089 89.72200012 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 83.3030014 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 87.8030014 89.72200012 Tm [(reticu)-1(lum)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 128.5269928 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 133.0269928 89.72200012 Tm [(\(ER\))] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 149.86199951 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 154.36199951 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 170.63900757 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 175.13900757 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 189.13999939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 193.63999939 89.72200012 Tm [(Go)1(l)-1(g)1(i)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 216.60099792 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 221.10099792 89.72200012 Tm [(complex.)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 259.74700928 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 264.24700928 89.72200012 Tm [(Th)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 47.11299896 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 51.61299896 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 82.91999817 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 87.41999817 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 93.98100281 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 98.48100281 105.3219986 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 141.44200134 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 145.94200134 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 158.22000122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 162.72000122 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 176.72099304 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 181.22099304 105.3219986 Tm [(org)1(anizat)1(ion)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 235.46699524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 239.96699524 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 248.80900574 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 253.30900574 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 267.30999756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 271.80999756 105.3219986 Tm [(s)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(moo)1(th,)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 30.93799973 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 35.43799973 120.92199707 Tm [(roug)1(h,)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 63.60699844 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 68.10700226 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 84.38400269 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 88.88400269 120.92199707 Tm [(exit)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 104.30000305 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 108.80000305 120.92199707 Tm [(site)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 123.82099915 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 128.32099915 120.92199707 Tm [(ER)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 139.14500427 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 143.64500427 120.92199707 Tm [(subd)1(omains.)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 198.26499939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 202.76499939 120.92199707 Tm [(A)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 209.0980072 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 213.5980072 120.92199707 Tm [(pseudog)1(e)-1(ne)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 267.15899658 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 8.84200001 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 13.34200001 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 28.79800034 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 33.29800034 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 54.81399918 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 59.31399918 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 73.9960022 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 78.4960022 136.52200317 Tm [(been)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 100.00299835 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 104.50299835 136.52200317 Tm [(identified.)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 147.6000061 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 152.1000061 136.52200317 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 198.82299805 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 203.32299805 136.52200317 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 236.23800659 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 240.73800659 136.52200317 Tm [(results)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 268.90701294 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 273.40701294 136.52200317 Tm [(i)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(multiple)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 45.41799927 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 49.91799927 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 90.83999634 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 95.33999634 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 131.07600403 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 252 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 253 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 254 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 0.75 m 139.05000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 157.5 m 139.05000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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