%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 124 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.51799774 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 163.28199768 23.67700005 Tm 0 Tr [(STX3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.34100342 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.78100586 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ST)-1(X3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.46299744 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 172.96299744 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.21299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(STX3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.44599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.81999969 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.59199524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.96600342 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.28700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.66099548 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45700073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(syntaxi)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.39600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.76999664 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.90100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.27500153 12.82499981 Tm [(ST)-1(X3A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.06300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ST)-1(X3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.71299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Rat,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.85399628 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.22799683 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 115.42500305 94.34999847 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.82300186 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.32300186 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.88399887 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.38399887 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.35900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.85900116 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.1230011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.6230011 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.46499634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.96499634 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.96600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.46600342 11.72200012 Tm [(syntaxin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.27200317 11.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.52000427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.02000427 11.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.82699585 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.32699585 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.83401489 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.33401489 11.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 27.3220005 Tm [(ta)1(rgeted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.95100021 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.45100021 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.52600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.02600098 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.02700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.52700043 27.3220005 Tm [(ap)1(i)-1(cal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.52700043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.02700043 27.3220005 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.81100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.31100464 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.15299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.65299988 27.3220005 Tm [(epith)1(e)-1(lial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.06300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.56300354 27.3220005 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.63900757 27.3220005 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.93600464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.43600464 27.3220005 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.18399048 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.68399048 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.25699997 42.92200089 Tm [(cl)-1(ust)1(e)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.93899918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.43899918 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.71600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.21600342 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.77700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.27700043 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.23800659 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.73800659 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.67900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.17900085 42.92200089 Tm [(estab)1(lishing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.72200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.22200012 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.49899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.99899292 42.92200089 Tm [(mainta)1(in)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.31399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.81399536 42.92200089 Tm [(po)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(larit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.31800079 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.81800079 58.52199936 Tm [(ne)-1(cessary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.59700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.09700012 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.875 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.18199921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.68199921 58.52199936 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.19200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.69200134 58.52199936 Tm [(involving)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.89599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.39599609 58.52199936 Tm [(vesic)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.30200195 58.52199936 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.79699707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.29699707 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.57400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(exocy)-1(t)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.63499832 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.13499832 74.12200165 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.85800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35800171 74.12200165 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.272995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.772995 74.12200165 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.94200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.44200134 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.38299561 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.88299561 74.12200165 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.25500488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.75500488 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.67700195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.17700195 74.12200165 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(STX3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.43700027 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(STX3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.78300476 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(syntaxin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.30599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.80599976 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.08399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(STX3)-1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.7689991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 0.75 m 115.05000305 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 95.09999847 m 115.05000305 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 111.44999695 m 115.05000305 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 127.79999542 m 115.05000305 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 144.1499939 m 115.05000305 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 160.5 m 115.05000305 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 176.4750061 m 423.17498779 176.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>