%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 139 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.33100128 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 162.09500122 23.67700005 Tm 0 Tr [(STN)1(1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.52799988 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 324.96798706 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ST)-1(N)1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 121.79100037 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.29100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.54100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(STN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.77400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.14800262 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.29400635 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.61500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.98899841 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.78500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ST)-1(N)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.04100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41500092 12.82499981 Tm [(su)-1(bun)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.88899994 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.63000488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.0039978 12.82499981 Tm [(CS)-1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.54400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.91799927 12.82499981 Tm [(compl)-1(e)1(x)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.79100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.16499329 12.82499981 Tm [(AA)1(F)-1(44)1(;OBFC)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.81100464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.18499756 12.82499981 Tm [(AA)1(F)-1(-44;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.82800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.20199585 12.82499981 Tm [(RPA)1(-32;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.0710144 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.44500732 12.82499981 Tm [(bA541N)1(10.2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.39599609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ST)-1(N)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.04100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0021002200230024000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 140.92500305 109.94999695 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(OBF)-1(C1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.06100082 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.56100082 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.83800125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.33800125 11.72200012 Tm [(C17)-1(ORF68)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.46099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.96099854 11.72200012 Tm [(\(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.1989975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.69900513 11.72200012 Tm [(61)-1(31)-1(29)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.37199402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.87199402 11.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.38999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.88999939 11.72200012 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.35600281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.85600281 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.69799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.19799805 11.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.71899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.21899414 11.72200012 Tm [(alp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51599979 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01599979 27.3220005 Tm [(acc)-1(essor)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3769989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.8769989 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.4960022 27.3220005 Tm [(\(AA)1(F\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.95400238 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.45400238 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.67599487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.17599487 27.3220005 Tm [(st)1(i)-1(mulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.06399536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.56399536 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.56500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.06500244 27.3220005 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.53700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.03700256 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.8789978 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.3789978 27.3220005 Tm [(DN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 42.92200089 Tm [(po)1(l)-1(ymerase-a)1(l)-1(p)1(ha-)1(primase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.36499786 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.86500549 42.92200089 Tm [(\(see)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.25 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.75 42.92200089 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.98199463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.48199463 42.92200089 Tm [(17)-1(66)-1(36)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.32099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.82099915 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.82200623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.32200623 42.92200089 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.70300293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.72200012 58.52199936 Tm [(initiat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.40599823 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.90599823 58.52199936 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.41100311 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.91100311 58.52199936 Tm [(replic)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.49499512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.99499512 58.52199936 Tm [(\(Cast)1(ee)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.1230011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.6230011 58.52199936 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.08200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.58200073 58.52199936 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.28500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.78500366 58.52199936 Tm [(20)-1(09)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89599609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.39599609 58.52199936 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.85900879 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(19)-1(11)-1(91)-1(39]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.40100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.90100098 74.12200165 Tm [(OBF)-1(C1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.96199799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.46199799 74.12200165 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.71900177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.21900177 74.12200165 Tm [(ap)1(pears)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.3730011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.8730011 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.94799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.44799805 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.18899536 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.68899536 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.63000488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.13000488 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.10499573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.60499573 74.12200165 Tm [(telomere-a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ssociat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.15299988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.65299988 89.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.13200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.63200378 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.02799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52799988 89.72200012 Tm [(C17)-1(ORF68)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.65100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.15100098 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.42799377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.92799377 89.72200012 Tm [(TEN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.63000488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.13000488 89.72200012 Tm [(\(C17)-1(ORF10)-1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.70300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(MIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.23200035 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.73200035 105.3219986 Tm [(61)-1(31)-1(30)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.40499878 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.90499878 105.3219986 Tm [(\(Miyak)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84400177 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.34400177 105.3219986 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.8030014 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.3030014 105.3219986 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.0059967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.5059967 105.3219986 Tm [(20)-1(09)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.61700439 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.11700439 105.3219986 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.58000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.08000183 105.3219986 Tm [(19)-1(85)-1(41)-1(30]\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.48100281 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.06500053 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56499863 11.72200012 Tm [(FC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.36700058 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(STN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.94799995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(STN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.29400635 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(STN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.94799995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.44799995 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.2480011 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.08999634 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.58999634 11.72200012 Tm [(CST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.96399689 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.46399689 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.94299316 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 0.75 m 140.55000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 110.69999695 m 140.55000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 127.04999542 m 140.55000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 143.3999939 m 140.55000305 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 159.75 m 140.55000305 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.7250061 m 423.17498779 175.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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