%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 128 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.73000336 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 155.4940033 23.67700005 Tm 0 Tr [(STAU1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 221.1289978 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 331.56900024 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ST)-1(A)1(U1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 127.82499695 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.32499695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.57499695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(STAU1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.80899811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.18299866 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.95500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.32899475 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.6499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.02400208 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.82000732 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(stauf)-1(e)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.11499786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.48899841 12.82499981 Tm [(do)-1(ub)-1(le-str)1(an)-1(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.51300049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.88699341 12.82499981 Tm [(RN)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.44099426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.81500244 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.64300537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.01699829 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.39898682 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.77301025 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.9039917 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.27801514 12.82499981 Tm [(ST)-1(A)1(U;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.84100342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.21499634 12.82499981 Tm [(PP)1(P1R1)1(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 341.47601318 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ST)-1(A)1(U1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.07499695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 125.17500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 125.17500305 172.3500061 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 298.625 -0.25 l 298.625 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sta)1(u)-1(f)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.84000015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.34000015 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.40100098 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.37599945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.87599945 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.13999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.63999939 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.48200226 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.98200226 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.98300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.48300171 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.56500244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.06500244 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.90699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.40699768 11.72200012 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.67100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.17100525 11.72200012 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.6960144 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.1960144 11.72200012 Tm [(\(ds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(RNA)1(\)-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.56800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.06800079 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.54100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.04100037 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.41000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.91000366 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.85099792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.35099792 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.352005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.852005 27.3220005 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.58700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.08700562 27.3220005 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.36799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.86799622 27.3220005 Tm [(localizat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.00499916 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.50499916 42.92200089 Tm [(mRNA)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.62900162 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.1289978 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.20400238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.70400238 42.92200089 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.64399719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.14399719 42.92200089 Tm [(subce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.36599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.86599731 42.92200089 Tm [(compar)1(tmen)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.65100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.15100098 42.92200089 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.43200684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.93200684 42.92200089 Tm [(org)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(anell)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.8560009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.35599899 58.52199936 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.43600082 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.93599701 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.40899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.90899658 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.42700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.92700195 58.52199936 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.46000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.96000671 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.47200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.97200012 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.9730072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.4730072 58.52199936 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.20199585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.70199585 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.54400635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.04400635 58.52199936 Tm [(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ltip)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.39299965 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.89299965 74.12200165 Tm [(dsR)1(NA-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.37799835 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.87799835 74.12200165 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.8710022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.3710022 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.46800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.96800232 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.48599243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.98599243 74.12200165 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.5269928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.0269928 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.102005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.602005 74.12200165 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.04800415 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.54800415 74.12200165 Tm [(RNA)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.23901367 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ha)1(vin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.93799973 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.43799973 89.72200012 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.70200348 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.20200348 89.72200012 Tm [(sec)-1(o)1(n)-1(d)1(ary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.18699646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.68699646 89.72200012 Tm [(st)1(ruc)-1(tures.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.47599792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.97599792 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.78300476 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.28300476 89.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.32400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.82400513 89.72200012 Tm [(ho)1(mo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(logue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.52599907 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.02599907 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.86800003 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.36800003 105.3219986 Tm [(st)1(aufen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18000031 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68000031 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.18699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.68699646 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.19900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.69900513 105.3219986 Tm [(STAU,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.27099609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.77099609 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.71200562 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.21200562 105.3219986 Tm [(ad)1(dition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.11099243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.61099243 105.3219986 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.82600403 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.32598877 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.30099487 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.80099487 105.3219986 Tm [(mic)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ot)1(u)-1(b)1(ul)-1(e-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.31000137 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.81000137 120.92199707 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.95400238 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.45400238 120.92199707 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.28099823 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.78099823 120.92199707 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.97599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.47599792 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.55099487 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.05099487 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.272995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.772995 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.61500549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.11500549 120.92199707 Tm [(mic)-1(r)1(otubule-ass)1(oc)-1(iat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.66999817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.16999817 136.52200317 Tm [(1B)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.26100159 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.76100159 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.03800201 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.53800201 136.52200317 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.15000153 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.65000153 136.52200317 Tm [(tub)1(u)-1(lin.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.34500122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.84500122 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.6519928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.1519928 136.52200317 Tm [(STAU)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.55700684 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.05700684 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.57299805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.07299805 136.52200317 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.14801025 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.64801025 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.32998657 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.50699997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.00699997 152.12199402 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08800125 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.58800125 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.66300201 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.16300201 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.01699829 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.51699829 152.12199402 Tm [(present)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97899628 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.47899628 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.41999817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.91999817 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.92100525 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.42100525 152.12199402 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.48899841 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.98899841 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.92999268 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.42999268 152.12199402 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.35699463 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.85699463 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.25299072 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 167.72200012 Tm [(roug)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.50299835 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.00299835 167.72200012 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.75900269 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.25900269 167.72200012 Tm [(reticu)-1(lum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.98300171 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.48300171 167.72200012 Tm [(\(RER)1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.36000061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.86000061 167.72200012 Tm [(implicating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.76499939 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.26499939 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.72099304 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.22099304 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.52801514 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 0.75 m 124.80000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>