%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.80000305 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 150.56399536 23.67700005 Tm 0 Tr [(STAT5A)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 226.05999756 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 336.5 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(ST)-1(A)1(T)-1(5A)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 132.28100586 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.78100586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.28100586 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(STAT5A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.26399994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.63800049 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.41000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.78399658 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.10499573 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.47900391 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.2749939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(si)-1(g)1(n)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41500092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.78900146 12.82499981 Tm [(transdu)-1(ce)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.97799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.352005 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.41499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.78900146 12.82499981 Tm [(activator)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.67199707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.04600525 12.82499981 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.78700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.16099548 12.82499981 Tm [(transcripti)-1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.99899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.37298584 12.82499981 Tm [(5A)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.57998657 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.95401001 12.82499981 Tm [(MGF;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.18899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.56298828 12.82499981 Tm [(ST)-1(A)1(T)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.01800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ST)-1(A)1(T)-1(5A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.53099823 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 144.67500305 172.3500061 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(STA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.15899992 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.6590004 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.74100113 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.24100113 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.08300018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.58300018 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.16699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.66699982 27.3220005 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.1190033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.6190033 27.3220005 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.80999756 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.30999756 27.3220005 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.30700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.80700684 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.88200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.38200378 27.3220005 Tm [(cy)-1(t)1(oki)-1(nes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.84698486 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.34698486 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 42.92200089 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.71900177 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.21900177 42.92200089 Tm [(fa)1(c)-1(t)1(ors,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.67099762 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.17099762 42.92200089 Tm [(STAT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.01599884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.51599884 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.5980072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.0980072 42.92200089 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.52799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.02799988 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.54600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.04600525 42.92200089 Tm [(ph)1(osph)1(orylate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.7689991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.2689991 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.27000046 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.77000046 58.52199936 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.19200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.69200134 58.52199936 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.81900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.31900024 58.52199936 Tm [(ki)-1(na)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.73899841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.23899841 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.51600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.01600647 58.52199936 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.56300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.06300354 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.77400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.27400208 58.52199936 Tm [(ho)1(mo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.89400005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.39400005 74.12200165 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.55200005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.05200005 74.12200165 Tm [(heterod)1(ime)-1(rs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.61199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.11199951 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.33399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.83399963 74.12200165 Tm [(tr)1(ansloc)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.37399292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.87399292 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.94900513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.44900513 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.44999695 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.94999695 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.36000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.86000061 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.67799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.17799377 74.12200165 Tm [(wh)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 89.72200012 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.37100029 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.87099838 89.72200012 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.7120018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.2120018 89.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.35300064 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.85300064 89.72200012 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.43699646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.93699646 89.72200012 Tm [(activat)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.71499634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.21499634 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.477005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.977005 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.28399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.78399658 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.34500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.84500122 89.72200012 Tm [(activat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 105.3219986 Tm [(by,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.04100037 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.54100037 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81800079 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31800079 105.3219986 Tm [(mediat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.61000061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.11000061 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.11100006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.61100006 105.3219986 Tm [(responses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.77400208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.27400208 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.11599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61599731 105.3219986 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.33299255 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.83299255 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.24299622 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.74299622 105.3219986 Tm [(ligand)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.8999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.3999939 105.3219986 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(uc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.60099983 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.10099983 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.24200058 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.74200058 120.92199707 Tm [(IL2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.45000076 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.95000076 120.92199707 Tm [(IL3)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.65799713 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.15799713 120.92199707 Tm [(IL7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.69999695 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.19999695 120.92199707 Tm [(GM-)1(CSF)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.74199677 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.24200439 120.92199707 Tm [(ery)-1(t)1(hro)1(poietin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.03300476 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.53300476 120.92199707 Tm [(th)1(rombo)1(poietin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.92001343 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.71699905 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.21699905 136.52200317 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.13300323 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.63300323 136.52200317 Tm [(ho)1(rmone)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.47200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.97200012 136.52200317 Tm [(Activa)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.27999878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.77999878 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.62199402 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.12199402 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.57800293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.07800293 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.38500977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.88500977 136.52200317 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(mye)-1(loma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.87400055 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.37400055 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.65100098 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.15100098 152.12199402 Tm [(lymphoma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.16200256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66200256 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.78900146 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.28900146 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.68499756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.18499756 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.16000366 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.66000366 152.12199402 Tm [(TEL/JAK2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.11799622 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.61799622 152.12199402 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 167.72200012 Tm [(fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.10100174 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.60100174 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.16199875 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.66199875 167.72200012 Tm [(indepen)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.6289978 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.1289978 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.97100067 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.47100067 167.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.8809967 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.3809967 167.72200012 Tm [(st)1(i)-1(mulus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.3809967 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.8809967 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.15800476 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.65800476 167.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.33999634 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.83999634 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.34700012 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.84700012 167.72200012 Tm [(sho)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 0.75 m 144.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>