%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 153 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.97899628 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 138.65499878 23.67700005 Tm 0 Tr [(TRAFD1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 215.8809967 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 326.3210144 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(TRAFD)-1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.25 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.75 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRA)1(F)-1(D1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.23300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.60700226 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.25700378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.6309967 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.19000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.56399536 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.36000061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FL)-1(N)1(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.66000366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRAFD)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 151.9750061 0.75 l 151.9750061 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 152.9750061 -0.25 l 152.9750061 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.7250061 0.75 m 422.42501831 0.75 l 422.42501831 125.55000305 l 152.7250061 125.55000305 l h f* Q q 1 0 0 1 152.3500061 0 cm -0.625 -0.25 m 271.07501221 -0.25 l 271.07501221 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(inn)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.22800064 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.72800064 11.72200012 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.18699646 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.68699646 11.72200012 Tm [(system)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.67500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.17500305 11.72200012 Tm [(confers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.78500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.28500366 11.72200012 Tm [(ho)1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.06700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.56700134 11.72200012 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.4750061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.9750061 11.72200012 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(viral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.92499924 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.42499924 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.70199966 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.20199966 27.3220005 Tm [(mic)-1(r)1(obial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.21399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.71399689 27.3220005 Tm [(infec)-1(t)1(i)-1(o)1(n,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.57700348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.07699585 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.35400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.85400391 27.3220005 Tm [(TRAFD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.13600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.63600159 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.19700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.69700623 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.67199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.17199707 27.3220005 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.13400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.63400269 27.3220005 Tm [(fe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(edba)1(c)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.99900055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.49900055 42.92200089 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.22599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.72599792 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.94799805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.44799805 42.92200089 Tm [(controls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.30099487 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.80099487 42.92200089 Tm [(exc)-1(essive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.64599609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.14599609 42.92200089 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.60499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.10499573 42.92200089 Tm [(respons)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.43900013 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.93900013 58.52199936 Tm [(Negat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.67200089 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.17200089 58.52199936 Tm [(feedba)1(c)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.39800262 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.89800262 58.52199936 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.625 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.125 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.34700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.84700012 58.52199936 Tm [(controls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.69999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.19999695 58.52199936 Tm [(exc)-1(essive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.04499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.54499817 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(nate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.97999954 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.47999954 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.93899918 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.43899918 74.12200165 Tm [(responses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.76899719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.26899719 74.12200165 Tm [(Regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.54899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.04899597 74.12200165 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.41299438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.91299438 74.12200165 Tm [(Toll-like)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.27400208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.77400208 74.12200165 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.1960144 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 89.72200012 Tm [(\(TLR4)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.72100067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.22100067 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.4980011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.9980011 89.72200012 Tm [(DD)1(X5)-1(8/)-1(R)1(IG1-lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.09700012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.59700012 89.72200012 Tm [(helic)-1(as)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.96099854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.46099854 89.72200012 Tm [(\(RLH\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.92799377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.42799377 89.72200012 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.22200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.53199959 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.03199959 105.3219986 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.40599823 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.90599823 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.90699768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.40699768 105.3219986 Tm [(LTR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.05999756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.55999756 105.3219986 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.02099609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.52099609 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.03300476 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.53300476 105.3219986 Tm [(direct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.09399414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.59399414 105.3219986 Tm [(interaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.93400574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.43400574 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.83000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.33000183 105.3219986 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(RA)1(F)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.2670002 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.7670002 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.04399872 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.54399872 120.92199707 Tm [(at)1(tenu)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.41300201 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.91300201 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.75499725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.25499725 120.92199707 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.13200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.63200378 120.92199707 Tm [(activat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.74899292 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 151.9750061 0.75 l 151.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.9750061 -0.25 l 152.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.7250061 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 152.7250061 16.35000038 l h f* Q q 1 0 0 1 152.3500061 0 cm -0.625 -0.25 m 271.07501221 -0.25 l 271.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 151.9750061 0.75 l 151.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.9750061 -0.25 l 152.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.7250061 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 152.7250061 16.35000038 l h f* Q q 1 0 0 1 152.3500061 0 cm -0.625 -0.25 m 271.07501221 -0.25 l 271.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TRAFD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.2820015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 151.9750061 0.75 l 151.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 152.9750061 -0.25 l 152.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 152.7250061 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 152.7250061 16.35000038 l h f* Q q 1 0 0 1 152.3500061 0 cm -0.625 -0.25 m 271.07501221 -0.25 l 271.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TRAFD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.62800598 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.3500061 0.75 m 152.3500061 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.3500061 126.30000305 m 152.3500061 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.3500061 142.65000916 m 152.3500061 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 152.3500061 159.00001526 m 152.3500061 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42501831 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42501831 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42501831 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17501831 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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