%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 126 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.73999786 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 156.5039978 23.67700005 Tm 0 Tr [(SORL1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 220.1190033 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 330.55899048 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(SO)-1(RL1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.96399689 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.46400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.71400452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(SORL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.9469986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.32099915 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.09300232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.78799438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.16200256 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.95799255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(sorti)-1(li)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.56700134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.94100189 12.82499981 Tm [(re)1(l)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.52300262 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.89700317 12.82499981 Tm [(re)1(ceptor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.67799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.05200195 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.18299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55700684 12.82499981 Tm [(LR11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.12600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.5 12.82499981 Tm [(LRP9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.17100525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.54499817 12.82499981 Tm [(SO)-1(RLA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.32199097 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.6960144 12.82499981 Tm [(gp250;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.92999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.3039856 12.82499981 Tm [(So)-1(r)1(L)-1(A)1(-)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.1619873 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.53601074 12.82499981 Tm [(C11orf32)] TJ ET EMC /P <> BDC BT 1 0 0 -1 371.82400513 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SO)-1(RL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.21399689 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.23400116 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 113.92500305 125.55000305 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(mosa)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.87400055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.37399292 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.18099976 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.40299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.90299988 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.34300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.84300232 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.91799927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.41799927 11.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.7460022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.2460022 11.72200012 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.24099731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.74099731 11.72200012 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.92199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(fa)1(mi)-1(lies:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.15200043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.65200043 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.65299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.15299988 27.3220005 Tm [(vacuolar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.43900299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.93900299 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.2460022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.7460022 27.3220005 Tm [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.1210022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.6210022 27.3220005 Tm [(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.17700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.67700195 27.3220005 Tm [(\(VPS1)-1(0\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.03100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.53100586 27.3220005 Tm [(do)1(main-c)-1(o)1(ntainin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.67900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.17900085 42.92200089 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.42700195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.92700195 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.20400238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.70400238 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.70500183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.20500183 42.92200089 Tm [(low)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.42799377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.92799377 42.92200089 Tm [(density)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.01499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.51499939 42.92200089 Tm [(lipop)1(rot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.08099365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.58099365 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.00299072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.50299072 42.92200089 Tm [(\(LDLR\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.48300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.24799919 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.7480011 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.55500031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.05500031 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.56199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.06199646 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.3690033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.8690033 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.12600708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.62600708 58.52199936 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.84100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.34100342 58.52199936 Tm [(fib)1(rone)-1(ctin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.22200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.72200012 58.52199936 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.69299316 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.19299316 58.52199936 Tm [(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.13000488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.63000488 58.52199936 Tm [(repe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.49400043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.99399948 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.27099991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.77099991 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.29199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.79199982 74.12200165 Tm [(epidermal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.14399719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.64399719 74.12200165 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.55999756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.05999756 74.12200165 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.17900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.67900085 74.12200165 Tm [(repeat.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.57099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.07099915 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.87800598 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.37800598 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88500977 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.38500977 74.12200165 Tm [(prepr)1(opr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.18299866 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.68299866 89.72200012 Tm [(pro)1(teolytically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.71900177 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.21900177 89.72200012 Tm [(pro)1(c)-1(essed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.94000244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.44000244 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.51499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.01499939 89.72200012 Tm [(gene)-1(r)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.40100098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.90100098 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.9019928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.4019928 89.72200012 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.25201416 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.75201416 89.72200012 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.33999634 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.09700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.59700012 105.3219986 Tm [(lik)-1(ely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.55199814 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.05199814 105.3219986 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.09899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.59899902 105.3219986 Tm [(roles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.42500305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.92500305 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.86599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.36599731 105.3219986 Tm [(en)-1(d)1(ocy)-1(t)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.57499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.07499695 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.352005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.852005 105.3219986 Tm [(sor)1(ting.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.39399719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.89399719 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.74301147 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.24301147 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.18399048 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.68399048 105.3219986 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10299969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60300064 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.11899948 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.61899948 120.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.79000092 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.29000092 120.92199707 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.14399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.64399719 120.92199707 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.77100372 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.27099609 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.66700745 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.16700745 120.92199707 Tm [(Alz)1(he)-1(imer's)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.81199646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.31199646 120.92199707 Tm [(disease.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.1499939 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SORL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.3010006 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q /GS2 gs 1 g 0.375 0.75 m 113.17500305 0.75 l 113.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.17500305 -0.25 l 114.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 113.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 113.92500305 16.35000038 l h f* Q q 1 0 0 1 113.55000305 0 cm -0.625 -0.25 m 309.875 -0.25 l 309.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(SORL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.64700317 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 0.75 m 113.55000305 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 126.30000305 m 113.55000305 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 142.65000916 m 113.55000305 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 113.55000305 159.00001526 m 113.55000305 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 174.60002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.97502136 m 423.17498779 174.97502136 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>