%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 106.10199738 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 155.77799988 23.67700005 Tm 0 Tr [(TPO)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 198.75700378 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 309.19699097 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(TPO)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.24299622 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 148.74299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.99299622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TPO)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.22699738 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.60099792 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.25100708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.625 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.18400574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.55799866 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.35400391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MSA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.68699646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.06099701 12.82499981 Tm [(TPX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.86199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.23600006 12.82499981 Tm [(TD)-1(H2)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.7519989 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TPO)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.49299622 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0019000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B001C000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001D0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001C0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 157.9750061 0.75 l 157.9750061 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 158.9750061 -0.25 l 158.9750061 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.7250061 0.75 m 422.42501831 0.75 l 422.42501831 172.3500061 l 158.7250061 172.3500061 l h f* Q q 1 0 0 1 158.3500061 0 cm -0.625 -0.25 m 265.07501221 -0.25 l 265.07501221 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(membrane-bo)1(un)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.16600037 11.72200012 Tm [(glyc)-1(o)1(prot)1(ei)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78999329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.28999329 11.72200012 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.11299896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61299896 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41999817 27.3220005 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.42700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.92700195 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.06800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.56800079 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.58900452 27.3220005 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.97000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.47000122 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.74699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.24699402 27.3220005 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.29400635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.79400635 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.76899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.26899719 27.3220005 Tm [(ce)-1(ntr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.36999989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.86999989 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.53000069 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.02999878 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97100067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47100067 42.92200089 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.43900299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.93900299 42.92200089 Tm [(gla)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.36799622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.86799622 42.92200089 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.7749939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.2749939 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.58200073 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.88900757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.38900757 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.29600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.79600525 42.92200089 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.04700089 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.54700089 58.52199936 Tm [(iodinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.35199738 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.85199738 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.69400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.19400024 58.52199936 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.68199921 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.18200684 58.52199936 Tm [(residues)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.86099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.36099243 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.30200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.80200195 58.52199936 Tm [(th)1(y)-1(r)1(oglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.12199402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.62199402 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(ph)1(e)-1(noxy-)1(e)-1(st)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.30799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.80799866 74.12200165 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51000214 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.01000214 74.12200165 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.08200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.58200073 74.12200165 Tm [(pa)1(i)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.30200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.80200195 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.64399719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.14399719 74.12200165 Tm [(iodinat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.14900208 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.64900208 74.12200165 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(yrosines)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.30099869 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.80099869 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.87599945 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.37599945 89.72200012 Tm [(gene)-1(r)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76200104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26200104 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.26300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.76300049 89.72200012 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.73100281 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.23100281 89.72200012 Tm [(ho)1(rmone)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.07000732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.57000732 89.72200012 Tm [(th)1(y)-1(r)1(oxine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.99499512 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.49499512 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(tr)1(i)-1(io)1(dot)1(hyronine)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.61299896 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.11299896 105.3219986 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96200562 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.46200562 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.40299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.90299988 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.35899353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.85899353 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.375 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.875 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.39300537 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.89300537 105.3219986 Tm [(asso)1(c)-1(iat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.65299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.15299988 120.92199707 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.06200027 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.56199646 120.92199707 Tm [(diso)1(rders)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.5039978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.0039978 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.84600067 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.34600067 120.92199707 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.31399536 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.81399536 120.92199707 Tm [(ho)1(rmonogene)-1(sis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.34500122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.84500122 120.92199707 Tm [(inc)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(uding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.5 136.52200317 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.80799866 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.30799866 136.52200317 Tm [(hypo)1(thyroid)1(ism,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.21200562 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.71200562 136.52200317 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.02000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.52000427 136.52200317 Tm [(go)1(i)-1(t)1(er,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.45599365 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.95599365 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.23300171 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.96800041 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.4679985 152.12199402 Tm [(ho)1(rmone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.97499847 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.47499847 152.12199402 Tm [(org)1(anific)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.32400513 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.82400513 152.12199402 Tm [(defec)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.77999878 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.27999878 152.12199402 Tm [(IIA.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.07000732 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57000732 152.12199402 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.30200195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.80200195 152.12199402 Tm [(tr)1(ans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(cript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.51599884 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.01599884 167.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35800171 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.85800171 167.72200012 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.33599854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.83599854 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.9960022 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.4960022 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.84300232 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.34300232 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.8500061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.3500061 167.72200012 Tm [(iden)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.3500061 0.75 m 158.3500061 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17501831 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>