%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 98.35199738 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 148.02799988 23.67700005 Tm 0 Tr [(TPM3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 206.50799561 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 316.94799805 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TPM3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 114.08999634 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 166.58999634 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.08999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TPM)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.57299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.9469986 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.59700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.97099304 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.52999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.90400696 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.69999695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TPM3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.96199799 12.82499981 Tm [(FL)-1(J41)1(118;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.96699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.27900696 12.82499981 Tm [(MGC1458)1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.89700317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.20899963 12.82499981 Tm [(MGC3261)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.5059967 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.81799316 12.82499981 Tm [(MGC7209)1(4;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.43600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.74798584 12.82499981 Tm [(NEM1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.76098633 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.07299805 12.82499981 Tm [(OK/SW-cl.)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.54800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.85998535 12.82499981 Tm [(TM-5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(TM3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.22500038 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.59900093 30.49699783 Tm [(TM30;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.14599991 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.52000046 30.49699783 Tm [(TM30nm;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.97100067 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.34500122 30.49699783 Tm [(TPMsk3)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.875 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.24899292 30.49699783 Tm [(TRK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.33200073 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.70599365 30.49699783 Tm [(hs)-1(c)1(p)-1(30)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.92900085 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TPM3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.83999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 148.2250061 0.75 l 148.2250061 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 149.2250061 -0.25 l 149.2250061 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 148.9750061 0.75 m 422.42501831 0.75 l 422.42501831 156.75 l 148.9750061 156.75 l h f* Q q 1 0 0 1 148.6000061 0 cm -0.625 -0.25 m 274.82501221 -0.25 l 274.82501221 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(tr)1(opomyos)1(i)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.28300476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.78300476 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.86500549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.36499023 11.72200012 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.11999989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.61999989 27.3220005 Tm [(actin-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.43900299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93900299 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.41200256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.91200256 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.28100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.78100586 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.72200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.22200012 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.2230072 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.7230072 27.3220005 Tm [(contractile)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.03100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.53100586 27.3220005 Tm [(system)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.51901245 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(st)1(riated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.88399887 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.38399887 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.66100311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.16100311 42.92200089 Tm [(smoo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.09799957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.59799957 42.92200089 Tm [(musc)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.92399597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.42399597 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.70100403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.20100403 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.20199585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.70199585 42.92200089 Tm [(cy)-1(t)1(oske)-1(leton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.3480072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.8480072 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.69000244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.19000244 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(on-muscle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.32099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.82099915 58.52199936 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.56300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.06300354 58.52199936 Tm [(Trop)1(omy)-1(o)1(sin)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.04200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.54200745 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.05999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.55999756 58.52199936 Tm [(dimers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.85400391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.35400391 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.19599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.69599915 58.52199936 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.50300598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.00300598 58.52199936 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ot)1(e)-1(ins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.28800011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.78800011 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.00999832 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.50999832 74.12200165 Tm [(po)1(l)-1(ymerize)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.54100037 74.12200165 Tm [(en)-1(d)1(-t)1(o-end)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.22099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.72099304 74.12200165 Tm [(along)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.11500549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.61500549 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.61599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.11599731 74.12200165 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.08599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.58599854 74.12200165 Tm [(gr)1(oove)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.05300903 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 89.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.11500168 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.61500168 89.72200012 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.39699936 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.89699936 89.72200012 Tm [(filaments.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.5530014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.0530014 89.72200012 Tm [(They)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.62399292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.12399292 89.72200012 Tm [(pro)1(vide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.01300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.51300049 89.72200012 Tm [(st)1(ability)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.05599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.55599976 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.6309967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.1309967 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.13200378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.63200378 89.72200012 Tm [(filam)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(en)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.94800186 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.44800186 105.3219986 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.1230011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.6230011 105.3219986 Tm [(acc)-1(ess)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.06199646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.56199646 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.40399933 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.90400696 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.06300354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.56300354 105.3219986 Tm [(actin-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.38200378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.88200378 105.3219986 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.52099609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.02099609 105.3219986 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 120.92199707 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.20600128 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.70600128 120.92199707 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.44799805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.94799805 120.92199707 Tm [(th)1(e)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.71299744 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.21299744 120.92199707 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.88800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.38800049 120.92199707 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.54800415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.04800415 120.92199707 Tm [(contractio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.12199402 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.62199402 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.13400269 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.63400269 120.92199707 Tm [(contro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(llin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.48800087 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.98800087 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.98899841 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.48899841 136.52200317 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.63300323 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.13300323 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.97499847 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.47499847 136.52200317 Tm [(myosin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.5 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 136.52200317 Tm [(head)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.54499817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.04499817 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.11999512 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.61999512 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.6210022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.1210022 136.52200317 Tm [(actin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.90299988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.40299988 136.52200317 Tm [(filament.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.89300537 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.39300537 136.52200317 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(utat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.05500031 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.55500031 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.49599838 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.99599838 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.45200348 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.95200348 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.46800232 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.96800232 152.12199402 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.97100067 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.47100067 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.41200256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.91200256 152.12199402 Tm [(auto)1(somal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.19799805 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.69799805 152.12199402 Tm [(do)1(mi)-1(na)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.42399597 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.92399597 152.12199402 Tm [(ne)-1(ma)1(li)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.6000061 0.75 m 148.6000061 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17501831 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>