%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 130 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.91200256 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 162.67599487 23.67700005 Tm 0 Tr [(SAT2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.94799805 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 324.38800049 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(SAT2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.64800262 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 171.147995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.397995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(SAT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.0719986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.44599915 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.21800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.59199524 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.91299438 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.28700256 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.08299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SS)-1(AT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.16300201 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SAT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.33799744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 112.42500305 172.3500061 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 311.375 -0.25 l 311.375 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SSAT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.15800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.65800095 11.72200012 Tm [(\(spermidine/spermin)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.53600311 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.03599548 11.72200012 Tm [(N1-ace)-1(t)1(yl)-1(t)1(ransf)1(e)-1(ra)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.01600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.51600647 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.5980072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.0980072 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.36199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.86199951 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.17199993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.67199993 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.92900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.42900085 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.2480011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.7480011 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.88899994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.38899994 27.3220005 Tm [(dia)1(m)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.9960022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.4960022 27.3220005 Tm [(ace)-1(t)1(yl)-1(t)1(ransf)1(e)-1(ra)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.98800659 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.48800659 27.3220005 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.93200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.43200684 27.3220005 Tm [(po)1(l)-1(yamine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.51499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.01501465 27.3220005 Tm [(N-a)1(c)-1(etyltr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ansfera)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.59700012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.09700012 42.92200089 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.375 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.875 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.03299713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.53299713 42.92200089 Tm [(th)1(ialy)-1(s)1(i)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16899872 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.66899872 42.92200089 Tm [(N-epsilon-)1(ac)-1(et)1(y)-1(lt)1(ransferase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.50999451 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.00999451 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.57099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.07099915 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.04600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.54598999 42.92200089 Tm [(17)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.3789978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.8789978 42.92200089 Tm [(amin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.72200012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.22200012 58.52199936 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.86199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.36199951 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.66899872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.16899872 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.39099884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.89099884 58.52199936 Tm [(exists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.63899994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.13899994 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.27999878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.77999878 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.75500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.25500488 58.52199936 Tm [(ho)1(modimer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.80099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.30099487 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.57800293 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.07800293 58.52199936 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.51800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.01800537 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.09298706 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.59298706 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.59399414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.09399414 58.52199936 Tm [(ace)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tyltr)1(ansferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.89799881 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.39799881 74.12200165 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.64600372 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.14600372 74.12200165 Tm [(Localizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.88699341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.38699341 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.46200562 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.96200562 74.12200165 Tm [(cy)-1(t)1(oplas)1(m,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.19700623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.69700623 74.12200165 Tm [(SSAT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.85499573 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.35499573 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.91600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.41600037 74.12200165 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.10598755 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.60598755 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.54699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.04699707 74.12200165 Tm [(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(one,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.54100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.04100037 89.72200012 Tm [(ce)-1(rvix,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.94400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.44400024 89.72200012 Tm [(ova)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.06500244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.56500244 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.84200287 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.34200287 89.72200012 Tm [(pineal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.50700378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.00700378 89.72200012 Tm [(gla)1(n)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.60299683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.10299683 89.72200012 Tm [(SSAT2)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.42799377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.92799377 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.0249939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.5249939 89.72200012 Tm [(sha)1(re)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.91600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.41598511 89.72200012 Tm [(46)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.97799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.47799683 89.72200012 Tm [(ami)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 105.3219986 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.40800095 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.90800095 105.3219986 Tm [(identity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.57700348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.07700348 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.15200043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65200043 105.3219986 Tm [(SSAT1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.97699738 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.47699738 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.03799438 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.53799438 105.3219986 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.69200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.19200134 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.13299561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.63299561 105.3219986 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.3500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.8500061 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.69200134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.19200134 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.19299316 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.69299316 105.3219986 Tm [(same)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.37298584 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.87298584 105.3219986 Tm [(tiss)1(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.91300011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.41300011 120.92199707 Tm [(SSAT1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.73799896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.23799896 120.92199707 Tm [(ho)1(weve)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.98100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.48100281 120.92199707 Tm [(SSAT1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63900757 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.13900757 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.69999695 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.19999695 120.92199707 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.897995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.397995 120.92199707 Tm [(wid)1(e)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.92100525 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.42100525 120.92199707 Tm [(expressed.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.74200439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.24200439 120.92199707 Tm [(SSAT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.3999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.8999939 120.92199707 Tm [(con)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ta)1(in)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.43499947 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.93499947 136.52200317 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.30899811 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.80899811 136.52200317 Tm [(N-a)1(c)-1(etyltra)1(nsferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.51199341 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.01199341 136.52200317 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.83900452 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.33900452 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.61599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.11599731 136.52200317 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.022995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.522995 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.66400146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.16400146 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.68499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.18499756 136.52200317 Tm [(en)-1(z)1(y)-1(me,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.73199463 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(cata)1(l)-1(yzing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.09700012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.59700012 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.59799957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.09799957 152.12199402 Tm [(ace)-1(t)1(yl)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.19400024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.69400024 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.53600311 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.03599548 152.12199402 Tm [(po)1(l)-1(yamines,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.45199585 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.95199585 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.22900391 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.72900391 152.12199402 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.8999939 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.3999939 152.12199402 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.65699768 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.15699768 152.12199402 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.99798584 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.49798584 152.12199402 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.63900757 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.13900757 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.11401367 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.61401367 152.12199402 Tm [(tr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ansciptiona)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.72800064 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.22800064 167.72200012 Tm [(co-activa)1(tor)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.96900177 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.46900177 167.72200012 Tm [(SSAT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.6269989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.1269989 167.72200012 Tm [(pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.81399536 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.31399536 167.72200012 Tm [(ubiquitinat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.98500061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.48498535 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.32699585 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.82699585 167.72200012 Tm [(HIF)-1(-)1(1)-1(a)1(l)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 0.75 m 112.05000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>