%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 129 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.86699677 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.54299927 23.67700005 Tm 0 Tr [(TOLLIP)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.99299622 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 321.43301392 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TOL)-1(LIP)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 118.21700287 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 170.71699524 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.21699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TOLL)-1(IP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.7009964 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.07499695 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.7250061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.09899902 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.65800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.03199768 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.82800293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TOL)-1(LIP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.96700287 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 167.7250061 63.15000153 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Comp)1(one)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.69599915 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.53800201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.03800201 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.03900146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.53900146 11.72200012 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.47000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.97000122 11.72200012 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.43099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.93099976 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.772995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.272995 11.72200012 Tm [(IL-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.70899963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.20899963 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.48599243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.98599243 11.72200012 Tm [(Toll-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.79599953 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.29599953 27.3220005 Tm [(rec)-1(ept)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.04999924 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.55000305 27.3220005 Tm [(Inhibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.33999634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.83999634 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.25 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.75 27.3220005 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.69999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.19999695 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.71200562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.21200562 27.3220005 Tm [(mic)-1(r)1(obial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.22399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.72399902 27.3220005 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ducts.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.50099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.00099945 42.92200089 Tm [(Rec)-1(ruit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.39299774 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.89299774 42.92200089 Tm [(IRA)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.23699951 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.31199646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.81199646 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.81300354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.31300354 42.92200089 Tm [(IL-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.74899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.24899292 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.67100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.17100525 42.92200089 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.81700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.31700134 42.92200089 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(hibit)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.59900093 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.09900093 58.52199936 Tm [(IRA)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.94300079 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.44300079 58.52199936 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.21699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.71699524 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.9940033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.4940033 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.58200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.08200073 58.52199936 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.72000122 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TOLL)-1(I)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.88299942 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 167.7250061 31.95000076 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hesized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.35400009 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.85400009 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.06800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.56800079 11.72200012 Tm [(derived)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3500061 11.72200012 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.06100464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56100464 11.72200012 Tm [(Internal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.40600586 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.44700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.94700623 11.72200012 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(OLLIP.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.88999939 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(to)1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.86499977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.36499977 11.72200012 Tm [(interacting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.73999786 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.23999786 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.54699707 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(0E2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.07699966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.8500061 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(30)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(kDa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.7859993 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 193.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 166.9750061 0.75 l 166.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 167.9750061 -0.25 l 167.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.59600067 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 167.7250061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 167.7250061 16.35000038 l h f* Q q 1 0 0 1 167.3500061 0 cm -0.625 -0.25 m 256.07501221 -0.25 l 256.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(vec,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.0170002 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.51699829 11.72200012 Tm [(Jurkat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.29100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.79100037 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.06800079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.56800079 11.72200012 Tm [(29)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.40100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.90100098 11.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.47699738 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.97699738 11.72200012 Tm [(lysates)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.9019928 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 209.55003357 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 0.75 m 167.3500061 63.15000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 63.90000153 m 167.3500061 79.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 80.25 m 167.3500061 95.84999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 96.59999847 m 167.3500061 127.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 128.55000305 m 167.3500061 144.15000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 144.90000916 m 167.3500061 160.50001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 161.25001526 m 167.3500061 176.85002136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 177.60002136 m 167.3500061 193.20002747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 167.3500061 193.95002747 m 167.3500061 209.55003357 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 209.55003357 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17500305 m 422.42498779 128.17500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.52500916 m 422.42498779 144.52500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.87501526 m 422.42498779 160.87501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 177.22502136 m 422.42498779 177.22502136 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 193.57502747 m 422.42498779 193.57502747 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.92503357 m 423.17498779 209.92503357 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>