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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.2990036 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 146.06300354 23.67700005 Tm 0 Tr [(SAMS)1(N1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 230.56100464 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 341.00100708 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(SAMS)-1(N)1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 136.55099487 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.05099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.30099487 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(SAMSN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.53500366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.90899658 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.68099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.05499268 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.37600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.75 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.54600525 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SAM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.8769989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.58300018 12.82499981 Tm [(do)-1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.59999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.30599976 12.82499981 Tm [(SH)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.9940033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.69999695 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.09700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.80299377 12.82499981 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.86599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.57200623 12.82499981 Tm [(nu)-1(clear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.3690033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.07499695 12.82499981 Tm [(lo)-1(cali)-1(zation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.46798706 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.17401123 12.82499981 Tm [(si)-1(g)1(n)-1(als)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.69500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.40100098 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.53201294 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.23800659 12.82499981 Tm [(SL)-1(y2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 346.36099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.06698608 12.82499981 Tm [(HACS1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 380.23901367 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 382.94500732 12.82499981 Tm [(NA)1(S)-1(H1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29598999 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(SAS)-1(H2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.39800072 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.77199936 30.49699783 Tm [(SH)-1(3)1(D)-1(6)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.95300293 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SAMS)-1(N)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.8010025 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 446.9289856 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 140.92500305 63.15000153 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SAMSN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.10900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.60900116 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.66999817 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.64500046 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.14500046 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.40899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.90899658 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.75099945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.25099945 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.22599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.72599792 11.72200012 Tm [(novel)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.21899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.71899414 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.23500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.73500061 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.81700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.31700134 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.15899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.65899658 11.72200012 Tm [(put)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.85900879 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.35900879 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(da)1(pto)1(rs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.1570015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.6570015 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.93399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.43399811 27.3220005 Tm [(scaff)1(old)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.20200348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.70200348 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.17500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.67500305 27.3220005 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.42199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.92199707 27.3220005 Tm [(SH)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.35499573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.85499573 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.13200378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.63200378 27.3220005 Tm [(SAM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.95199585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.45199585 27.3220005 Tm [(\(st)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ile)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.89599991 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.39599991 42.92200089 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.02999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.52999878 42.92200089 Tm [(mot)1(if\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.55899811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.05899811 42.92200089 Tm [(do)1(mains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.05200195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.55200195 42.92200089 Tm [(\(Claudio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.36700439 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.86700439 42.92200089 Tm [(et)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.32600403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.82600403 42.92200089 Tm [(al.,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.52900696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.02900696 42.92200089 Tm [(20)-1(01)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.13999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.63999939 42.92200089 Tm [([PubMed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.10299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.60299683 42.92200089 Tm [(11)-1(53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(60)-1(50)-1(]\).)1([supplied)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.15699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.65699768 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.16899872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.66899872 58.52199936 Tm [(OMIM,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.40200043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.90200043 58.52199936 Tm [(Mar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.10699463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.60699463 58.52199936 Tm [(20)-1(08)-1(])] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.72399902 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SAMSN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.10900116 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(SAMSN1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.45500183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SAM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.31999969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.81999969 11.72200012 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.31400299 11.72200012 Tm [(SH)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.74700165 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.24700165 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.0739975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.5739975 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.35099792 11.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.8690033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.3690033 11.72200012 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.17900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.67900085 11.72200012 Tm [(signals)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.07800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.57800293 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.85598755 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(SLy)-1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.02099991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.52099991 11.72200012 Tm [(HACS1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.47399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.97399902 11.72200012 Tm [(NASH1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.22299957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.72299957 11.72200012 Tm [(SASH2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.84899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.34899902 11.72200012 Tm [(SH)-1(3D6B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.56199646 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9NS)-1(I)1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.04700089 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 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63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 112.57499695 m 422.42498779 112.57499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.92500305 m 422.42498779 128.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 145.27500916 m 422.42498779 145.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 161.62501526 m 423.17498779 161.62501526 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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