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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.95999908 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 151.72399902 23.67700005 Tm 0 Tr [(NKX)1(2-1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 224.8999939 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 335.33999634 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(NK)1(X2-1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.29100037 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.79100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.04100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(KX2-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.27400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.64800262 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.41999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.79400635 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.11500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.48899841 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.28500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NK)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.55500031 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.91400146 12.82499981 Tm [(ho)-1(me)1(ob)-1(ox)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.71800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.07699585 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.20799255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.56700134 12.82499981 Tm [(BCH;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.22900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.58799744 12.82499981 Tm [(BHC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.60899353 12.82499981 Tm [(NK)1(-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.18800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.54699707 12.82499981 Tm [(TE)-1(BP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.73599243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.09500122 12.82499981 Tm [(TT)-1(F1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.28399658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.64300537 12.82499981 Tm [(NK)1(X2A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.5329895 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 317.89199829 12.82499981 Tm [(NM)1(T)-1(C1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 352.49398804 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 356.85299683 12.82499981 Tm [(T/)-1(EBP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 385.09698486 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.45599365 12.82499981 Tm [(TIT)-1(F1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29098511 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(TT)-1(F-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.40399933 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.77799988 30.49699783 Tm [(NK)1(X2.1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.75500107 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NK)1(X2-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.54100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 173.92500305 0.75 l 173.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 174.92500305 -0.25 l 174.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 174.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 174.67500305 156.75 l h f* Q q 1 0 0 1 174.30000305 0 cm -0.625 -0.25 m 249.125 -0.25 l 249.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(initially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.08900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.58900452 11.72200012 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.52000427 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.02000427 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.16099548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.66099548 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.63600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.13600159 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(hyroid)1(-speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.4659996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.96600342 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.55000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.05000305 27.3220005 Tm [(fa)1(c)-1(t)1(or.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.33599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.83599854 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.64300537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.14300537 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.6499939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.1499939 27.3220005 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 42.92200089 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.1590004 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.6590004 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.73400116 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.23400116 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.23500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.73500061 42.92200089 Tm [(th)1(y)-1(r)1(oglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.05499268 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.55499268 42.92200089 Tm [(pro)1(moter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.51199341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.01199341 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.28900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.78900146 42.92200089 Tm [(regulat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.77300072 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.27299881 58.52199936 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.22699738 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.72699738 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.56900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.06900024 58.52199936 Tm [(th)1(y)-1(r)1(oid-s)1(pec)-1(ific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.88800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.38800049 58.52199936 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07000732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.57000732 58.52199936 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.21699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.71699524 58.52199936 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.39900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.89900208 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(lso)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.28299999 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.78300095 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.29000092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.79000092 74.12200165 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.8710022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.3710022 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.44599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.94599915 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.6210022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.1210022 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.12199402 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.62199402 74.12200165 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57600403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.07600403 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.91799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.41799927 74.12200165 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.1000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.36899948 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.86899948 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.81000137 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.31000137 89.72200012 Tm [(morp)1(hog)1(e)-1(nesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.3219986 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.8219986 89.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.67100525 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.17100525 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.44799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.94799805 89.72200012 Tm [(dele)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.4940033 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.89699936 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.39699936 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.9129982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.4129982 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.93099976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.43099976 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.55799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.05799866 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.95399475 105.3219986 Tm [(benign)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.05200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55200195 105.3219986 Tm [(heredita)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.42300415 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.92300415 105.3219986 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ho)1(re)-1(a)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.9470005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.4470005 120.92199707 Tm [(choreoat)1(hetos)1(i)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.43199921 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.93199921 120.92199707 Tm [(congen)-1(it)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.24000549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.74000549 120.92199707 Tm [(hypo)1(thyroid)1(ism,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.64399719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.14399719 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 136.52200317 Tm [(ne)-1(o)1(n)-1(a)1(tal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.41999817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.91999817 136.52200317 Tm [(respira)1(tory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.45800018 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.95800018 136.52200317 Tm [(dist)1(ress,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.66999817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.16999817 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.44700623 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.94700623 136.52200317 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.11799622 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.61799622 136.52200317 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.47200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.97200012 136.52200317 Tm [(asso)1(c)-1(ia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.2159996 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.7159996 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.11199951 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.61199951 152.12199402 Tm [(th)1(y)-1(r)1(oid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.58000183 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.08000183 152.12199402 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.33599854 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.83599854 152.12199402 Tm [(Multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.56799316 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.06799316 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.99000549 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.49000549 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.05999756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.55999756 152.12199402 Tm [(e)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 174.30000305 0.75 m 174.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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