%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 126 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.02300262 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 152.78700256 23.67700005 Tm 0 Tr [(NFKB)1(IE)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 223.83599854 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 334.27600098 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(NFKB)1(IE)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 130.29100037 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.79100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.04100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(F)-1(K)1(BIE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.27500153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.64900208 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.42100525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.79499817 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.49000549 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.28599548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.76899719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.14299774 12.82499981 Tm [(in)-1(hi)-1(bi)-1(tor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.63700104 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.01100159 12.82499981 Tm [(epsi)-1(lon)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.54100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.91499329 12.82499981 Tm [(IK)1(BE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.85400391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NFKB)1(IE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.54100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 179.92500305 0.75 l 179.92500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 180.92500305 -0.25 l 180.92500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 180.67500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 180.67500305 109.94999695 l h f* Q q 1 0 0 1 180.30000305 0 cm -0.625 -0.25 m 243.125 -0.25 l 243.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.71699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.21699524 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.29200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.79200745 11.72200012 Tm [(compo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ne)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.71699905 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.21699905 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.05899811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.55899811 27.3220005 Tm [(NF-kapp)1(a-B,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.60299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.10299683 27.3220005 Tm [(tr)1(app)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.06100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.56100464 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.56199646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.06199646 27.3220005 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.54100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.04100037 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.98199463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.48199463 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.48300171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.06800079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.56800079 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.84500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.34500122 42.92200089 Tm [(preventing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.06300354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.56300354 42.92200089 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.31099701 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.81100464 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.52200317 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.02200317 42.92200089 Tm [(activat)1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.00700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.50700378 42.92200089 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.18899536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.44199944 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.94199944 58.52199936 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.92700195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.42700195 58.52199936 Tm [(Pho)1(spho)1(ryl)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.95899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.45899963 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.30099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.80099487 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.80200195 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.30200195 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.80900574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.30900574 58.52199936 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.39999962 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.89999962 74.12200165 Tm [(ta)1(rgets)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.04600143 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.54600143 74.12200165 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29399872 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.79399872 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.0719986 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.5719986 74.12200165 Tm [(dest)1(ru)-1(ctio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.46600342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.96600342 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.47799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.97799683 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.97900391 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.47900391 74.12200165 Tm [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.16000366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.66000366 74.12200165 Tm [(pa)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(wa)1(y)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.01099968 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.51099968 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.60800171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.10800171 89.72200012 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.66799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.16799927 89.72200012 Tm [(NF-kapp)1(a-B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.04499817 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.54499817 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.05700684 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.55700684 89.72200012 Tm [(makin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.56199646 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.06199646 89.72200012 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.80999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.30999756 89.72200012 Tm [(ava)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ab)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.22400093 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.72400093 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.79899979 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29899979 105.3219986 Tm [(tr)1(ansloc)-1(a)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.83899689 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.33899689 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.41400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.91400146 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.91500092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.41500092 105.3219986 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.3999939 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 179.92500305 0.75 l 179.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.92500305 -0.25 l 180.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 180.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 180.67500305 16.35000038 l h f* Q q 1 0 0 1 180.30000305 0 cm -0.625 -0.25 m 243.125 -0.25 l 243.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 179.92500305 0.75 l 179.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.92500305 -0.25 l 180.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 180.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 180.67500305 16.35000038 l h f* Q q 1 0 0 1 180.30000305 0 cm -0.625 -0.25 m 243.125 -0.25 l 243.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFKBIE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.05200005 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 179.92500305 0.75 l 179.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.92500305 -0.25 l 180.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 180.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 180.67500305 16.35000038 l h f* Q q 1 0 0 1 180.30000305 0 cm -0.625 -0.25 m 243.125 -0.25 l 243.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(NFKBIE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.397995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 179.92500305 0.75 l 179.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 180.92500305 -0.25 l 180.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 180.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 180.67500305 16.35000038 l h f* Q q 1 0 0 1 180.30000305 0 cm -0.625 -0.25 m 243.125 -0.25 l 243.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NFKB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.45800018 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.95800018 11.72200012 Tm [(inhibito)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.48999786 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.98999786 11.72200012 Tm [(epsilon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.06800079 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.30000305 0.75 m 180.30000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.30000305 110.69999695 m 180.30000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.30000305 127.04999542 m 180.30000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.30000305 143.3999939 m 180.30000305 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 180.30000305 159.75 m 180.30000305 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 175.7250061 m 423.17498779 175.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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