%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 150 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.71800232 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 162.48199463 23.67700005 Tm 0 Tr [(SAFB)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.14100647 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 324.58099365 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(SAF)-1(B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 121.18599701 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.68600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.18600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(SAFB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.16899872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.54299927 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.31500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.68899536 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.00999451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.38400269 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.17999268 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(scaffo)-1(ld)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.44799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.8219986 12.82499981 Tm [(attachment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.51800537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.89199829 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.28100586 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.65499878 12.82499981 Tm [(B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.17599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55000305 12.82499981 Tm [(HAP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.40100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.7749939 12.82499981 Tm [(HET)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.36999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.7440033 12.82499981 Tm [(SAF)-1(-B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.20401001 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.57800293 12.82499981 Tm [(SAF)-1(B1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.14498901 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.51901245 12.82499981 Tm [(SAB-B1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.18798828 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.56201172 12.82499981 Tm [(SAF)-1(-B1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.53399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(SAF)-1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.43599701 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 139.0249939 0.75 l 139.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 140.0249939 -0.25 l 140.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 139.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 139.7749939 172.3500061 l h f* Q q 1 0 0 1 139.3999939 0 cm -0.625 -0.25 m 284.0249939 -0.25 l 284.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.21200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.71200562 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.51899719 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.61599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.11599731 11.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.79800415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.29800415 11.72200012 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.5329895 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.0329895 11.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(pec)-1(if)1(ic)-1(ity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.3030014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.8030014 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.08100128 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.58100128 27.3220005 Tm [(scaff)1(old)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.34899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84899902 27.3220005 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.00700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.50700378 27.3220005 Tm [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.66099548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.16099548 27.3220005 Tm [(at)1(tachment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.30900574 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.80900574 27.3220005 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.77099609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.27099609 27.3220005 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.77600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.27600098 27.3220005 Tm [(ele)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(en)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 42.92200089 Tm [(\(S/MAR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.7179985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.2179985 42.92200089 Tm [(DNA)1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.89499664 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.39499664 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.65699768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.15699768 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46400452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.5249939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.0249939 42.92200089 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.83799744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.33799744 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.41299438 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.91299438 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.76699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.26699829 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.63598633 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.13598633 42.92200089 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 58.52199936 Tm [(at)1(taching)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.45399857 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.95399857 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.95500183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.45500183 58.52199936 Tm [(ba)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.44999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.94999695 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.79199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.29199982 58.52199936 Tm [(chromat)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.20700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.70700073 58.52199936 Tm [(loop)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.45899963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.95899963 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.03399658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.53399658 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.53500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.03500366 58.52199936 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.55299377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05300903 58.52199936 Tm [(mat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.39299965 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.89299965 74.12200165 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.54000092 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.04000092 74.12200165 Tm [(th)1(e)-1(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.58399963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.08399963 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.64499664 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.14499664 74.12200165 Tm [(conflic)-1(t)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.40000153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.90000153 74.12200165 Tm [(eviden)-1(ce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.15400696 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.65400696 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.79499817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.29499817 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.36999512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.86999512 74.12200165 Tm [(wh)1(e)-1(t)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.06100464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.56100464 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.01699829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.51699829 74.12200165 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.00200081 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.50200081 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.47699928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.97700119 89.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.66600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.16600037 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.00800323 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.50800323 89.72200012 Tm [(chromat)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.42300415 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.92300415 89.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.08099365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.58099365 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.55599976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.05599976 89.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.57400513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.07400513 89.72200012 Tm [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.22799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.72799683 89.72200012 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.20098877 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(Sc)-1(a)1(ffo)1(l)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.79600143 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.29600143 105.3219986 Tm [(at)1(tachment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.44400024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.94400024 105.3219986 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.22899628 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.72899628 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.24699402 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.74699402 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.72200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.22200012 105.3219986 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.17900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.67900085 105.3219986 Tm [(subset)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.76400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.26400757 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.10600281 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.60600281 105.3219986 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.12399292 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.15399933 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.65399933 120.92199707 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.1269989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.6269989 120.92199707 Tm [(\(NMP\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.25499725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.75499725 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.97699738 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.47699738 120.92199707 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.96200562 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.46200562 120.92199707 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.90800476 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.40800476 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.48300171 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.98300171 120.92199707 Tm [(S/MAR.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.19099426 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.69099426 120.92199707 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.49798584 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.50699997 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.00699997 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.31400299 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.81400299 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.375 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.875 136.52200317 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.68800354 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.18800354 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.26300049 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.76300049 136.52200317 Tm [(serve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.30299377 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.80299377 136.52200317 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.94400024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.44400024 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.41900635 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.91900635 136.52200317 Tm [(molec)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.44000244 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.94000244 136.52200317 Tm [(ba)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.93499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.43499756 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.51000977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(assemble)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.09600067 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.59600067 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.57099915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.07099915 152.12199402 Tm [('tra)1(n)-1(script)1(osome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.4489975 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.94900513 152.12199402 Tm [(complex')] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.73500061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.23500061 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.17599487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.67599487 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.67700195 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.17700195 152.12199402 Tm [(vici)-1(nit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.26199341 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.76199341 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.60400391 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.10400391 152.12199402 Tm [(activ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.26500034 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.76499939 167.72200012 Tm [(tr)1(ansc)-1(rib)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.1969986 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.6969986 167.72200012 Tm [(gene)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.54499817 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.04499817 167.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.04399872 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.54399872 167.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.10500336 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.60500336 167.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.97399902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.47399902 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.41499329 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.91499329 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.91600037 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.41600037 167.72200012 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.64700317 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.14700317 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.98899841 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.48901367 167.72200012 Tm [(hea)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.3999939 0.75 m 139.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>