%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 135 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.88300323 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.55900574 23.67700005 Tm 0 Tr [(TNN)1(T)-1(2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.977005 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 321.41699219 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(TNN)1(T)-1(2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 107.86100006 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.36099243 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.86099243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TN)1(NT2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.84400177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.21800232 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.86799622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.24200439 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.80099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.17500305 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.97099304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CMH2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.24900055 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.6230011 12.82499981 Tm [(RCM3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.03099823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.40499878 12.82499981 Tm [(Tn)-1(TC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.56300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.93699646 12.82499981 Tm [(cTn)-1(T;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.93699646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.31100464 12.82499981 Tm [(CMD1D;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.93800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.31199646 12.82499981 Tm [(CMPD2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.90400696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.27799988 12.82499981 Tm [(LV)-1(N)1(C)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.34799194 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNN)1(T)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.11100006 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 157.9750061 0.75 l 157.9750061 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 158.9750061 -0.25 l 158.9750061 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 158.7250061 0.75 m 422.42501831 0.75 l 422.42501831 172.3500061 l 158.7250061 172.3500061 l h f* Q q 1 0 0 1 158.3500061 0 cm -0.625 -0.25 m 265.07501221 -0.25 l 265.07501221 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.16700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.66700745 11.72200012 Tm [(tr)1(opomyos)1(i)-1(n-)1(bi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.5 27.3220005 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.79999924 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.30000305 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.14199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.64199829 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.64299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.14299774 27.3220005 Tm [(tr)1(oponin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.61099243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.11099243 27.3220005 Tm [(complex,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.75700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.25700378 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.35400391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.85400391 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.41499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.91499329 27.3220005 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.73599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.7689991 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.26900101 42.92200089 Tm [(th)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.10400009 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.60400009 42.92200089 Tm [(filament)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.92700195 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.42700195 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.26899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.76899719 42.92200089 Tm [(st)1(riated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.31100464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.81100464 42.92200089 Tm [(musc)-1(les)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.13699341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.63699341 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.91400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.41400146 42.92200089 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.25500488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.15999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.65999985 58.52199936 Tm [(contractio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.73400116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.23400116 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.17500305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.67500305 58.52199936 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.67199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.17199707 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.24699402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.74699402 58.52199936 Tm [(alt)1(e)-1(ra)1(tions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.16900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.66900635 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.61000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.11000061 58.52199936 Tm [(intra)1(c)-1(ell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.35199928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.85199928 74.12200165 Tm [(calc)-1(ium)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.62200165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.12200165 74.12200165 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.78500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.28500366 74.12200165 Tm [(conc)-1(entrat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.17799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.67799377 74.12200165 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.5269928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.0269928 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.96800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.46800232 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.92399597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.42399597 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.94000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.44000244 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ave)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.30500031 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.81200027 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.31200027 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.43900299 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.93900299 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.33499908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.83499908 89.72200012 Tm [(fa)1(mi)-1(lia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.91799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.41799927 89.72200012 Tm [(hypert)1(roph)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.7230072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.2230072 89.72200012 Tm [(cardiomy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(op)1(ath)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.10300064 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.60300064 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.74399948 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.24399948 105.3219986 Tm [(well)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.2460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.7460022 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.88700104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.38700104 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.78299713 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.28299713 105.3219986 Tm [(dilat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.02099609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.52099609 105.3219986 Tm [(cardiomyop)1(ath)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.78500366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.28500366 105.3219986 Tm [(Transcrip)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.51900005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.01900005 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.29700089 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.79700089 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.25299835 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.26899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.76899719 120.92199707 Tm [(undergo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.63899994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.13899994 120.92199707 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.5039978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.0039978 120.92199707 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.91900635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.41900635 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64100647 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.14100647 120.92199707 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.30999756 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 136.52200317 Tm [(many)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.15800095 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.65800095 136.52200317 Tm [(tiss)1(u)-1(e-sp)1(e)-1(cific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.24099731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.74099731 136.52200317 Tm [(isof)1(orms,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06799316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.56799316 136.52200317 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.477005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.977005 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.97799683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.47799683 136.52200317 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.52600098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nature)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.96199989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.4620018 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.30400085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.80400085 152.12199402 Tm [(some)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.23100281 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.73100281 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.57299805 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.07299805 152.12199402 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.34600067 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.84600067 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.41600037 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.91600037 152.12199402 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.5980072 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.0980072 152.12199402 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.71899414 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.21899414 152.12199402 Tm [(ye)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.44200134 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.94200134 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.44900513 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.94900513 152.12199402 Tm [(dete)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(rmine)-1(d)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.84000015 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.3500061 0.75 m 158.3500061 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17501831 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>