%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 150 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.05699921 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.82099915 23.67700005 Tm 0 Tr [(S1)1(00A10)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 230.80200195 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 341.24200439 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(S100A1)1(0)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 137.25900269 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.75900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.75900269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(S100A)1(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.24199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.61599731 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.38800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.76199341 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.08299255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.45700073 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.25300598 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(S100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.79000092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.91400146 12.82499981 Tm [(calci)-1(um)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.54699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.67099762 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.49899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.6230011 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.00500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.1289978 12.82499981 Tm [(A1)1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.65800476 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.78199768 12.82499981 Tm [(42C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.83399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.95799255 12.82499981 Tm [(P1)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.83499146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.95901489 12.82499981 Tm [(p10;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.9289856 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.05300903 12.82499981 Tm [(GP)1(11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.5539856 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 318.67800903 12.82499981 Tm [(AN)1(X2L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 349.52700806 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 353.65100098 12.82499981 Tm [(CAL1L;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 382.28500366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 386.40899658 12.82499981 Tm [(CL)-1(P)1(11;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29901123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(Ca[1])1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.1989994 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.57299995 30.49699783 Tm [(AN)1(X2LG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.23600006 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(S100A1)1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.50900269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 431.32901001 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 459.26800537 cm q /GS2 gs 1 g 0.375 0.75 m 126.27500153 0.75 l 126.27500153 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 127.27500153 -0.25 l 127.27500153 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.02500153 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 127.02500153 125.55000305 l h f* Q q 1 0 0 1 126.65000153 0 cm -0.625 -0.25 m 296.7749939 -0.25 l 296.7749939 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(S1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.77600098 11.72200012 Tm [(fa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.98699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.48699951 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.32900047 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.82899857 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.30200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.80200195 27.3220005 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.5490036 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.0490036 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.32699585 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.82699585 27.3220005 Tm [(EF-h)1(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.26899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.76899719 27.3220005 Tm [(calc)-1(ium-b)1(i)-1(nd)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.57600403 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.07600403 27.3220005 Tm [(mot)1(ifs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.43099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(S1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.02799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.52799988 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.00099945 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.50099945 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.01899719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.51899719 42.92200089 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.20200348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.70200348 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.64300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.14300537 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.14399719 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.64399719 42.92200089 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.71200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.21200562 42.92200089 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.49299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.99299622 42.92200089 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.81100464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.31100464 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.15301514 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 58.52199936 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.8390007 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.3390007 58.52199936 Tm [(rang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.1590004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.6590004 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.50099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.00099945 58.52199936 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.74299622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.24299622 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.51999664 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.01999664 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.38900757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.88900757 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.83000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.33000183 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.33099365 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.83099365 58.52199936 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.06199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.56199646 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.40400696 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.9039917 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.8789978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.3789978 58.52199936 Tm [(num)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ber)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.29100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.79100037 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.63299942 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.13299942 74.12200165 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.89500046 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.39499664 74.12200165 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.52500153 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.02500153 74.12200165 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.79200745 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.29200745 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.43299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.93299866 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.34300232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.84300232 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.13499451 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.63499451 74.12200165 Tm [(pro)1(gression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.83599854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.33599854 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.61300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.11300659 74.12200165 Tm [(dif)1(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ere)-1(nt)1(iation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.09999847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.59999847 89.72200012 Tm [(S1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.62799835 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.12799835 89.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.80999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.30999756 89.72200012 Tm [(inc)-1(lude)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56799316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06799316 89.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.39599609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.89599609 89.72200012 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.89100647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.39100647 89.72200012 Tm [(13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.94700623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.44700623 89.72200012 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.8769989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.3769989 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.47399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.97399902 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.49200439 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.82099915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.32099915 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.4620018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.9620018 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.93700027 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.43700027 105.3219986 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.95300293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.45300293 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.72100067 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.22100067 105.3219986 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.01600647 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.51600647 105.3219986 Tm [(1q2)-1(1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.272995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.772995 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.03500366 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.53500366 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.84199524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.34199524 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.51300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.01300049 105.3219986 Tm [(fu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(nc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.07500076 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.57500076 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.51599884 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.01599884 120.92199707 Tm [(exocy)-1(t)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.48400116 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.98400116 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.26100159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.76100159 120.92199707 Tm [(en)-1(d)1(ocy)-1(t)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.13699341 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 126.27500153 0.75 l 126.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 127.27500153 -0.25 l 127.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 127.02500153 16.35000038 l h f* Q q 1 0 0 1 126.65000153 0 cm -0.625 -0.25 m 296.7749939 -0.25 l 296.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IP,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.79000092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29000092 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.71699905 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 126.27500153 0.75 l 126.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 127.27500153 -0.25 l 127.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 127.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 127.02500153 16.35000038 l h f* Q q 1 0 0 1 126.65000153 0 cm -0.625 -0.25 m 296.7749939 -0.25 l 296.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(S1)-1(00A10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.91600037 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 126.65000153 0.75 m 126.65000153 125.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 126.65000153 126.30000305 m 126.65000153 141.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 126.65000153 142.65000916 m 126.65000153 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 158.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 158.62501526 m 423.17498779 158.62501526 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>