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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.88300323 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.55900574 23.67700005 Tm 0 Tr [(TNN)1(T)-1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 210.977005 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 321.41699219 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(TNN)1(T)-1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 107.86100006 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.36099243 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 165.61099243 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TN)1(NT1)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 112.84400177 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 115.21800232 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 140.86799622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 143.24200439 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 186.80099487 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 189.17500305 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 226.97099304 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tropo)-1(ni)-1(n)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 100.21099854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 102.58499908 12.82499981 Tm [(T1,)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 115.64299774 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 118.01699829 12.82499981 Tm [(sl)-1(ow)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 137.57600403 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 139.94999695 12.82499981 Tm [(ske)1(l)-1(e)1(tal)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 172.64500427 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 175.01899719 12.82499981 Tm [(type;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 196.83900452 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 199.21299744 12.82499981 Tm [(AN)1(M;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 223.85299683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 226.227005 12.82499981 Tm [(TNT;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 246.04800415 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 248.42199707 12.82499981 Tm [(NEM5;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 277.43499756 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 279.80899048 12.82499981 Tm [(ST)-1(N)1(T)-1(;)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 304.45401001 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 306.82800293 12.82499981 Tm [(TNTS)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 328.66400146 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNN)1(T)-1(1)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 92.11100006 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 85 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 88 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 153.4750061 0.75 l 153.4750061 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 154.4750061 -0.25 l 154.4750061 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 89 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 154.2250061 0.75 m 422.42501831 0.75 l 422.42501831 172.3500061 l 154.2250061 172.3500061 l h f* Q q 1 0 0 1 153.8500061 0 cm -0.625 -0.25 m 269.57501221 -0.25 l 269.57501221 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 91 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 161.75999451 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 166.25999451 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 171.23500061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 175.73500061 11.72200012 Tm [(subunit)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 208.03500366 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 212.53500366 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 221.3769989 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 225.8769989 11.72200012 Tm [(tr)1(oponi)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n,)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 7.71199989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 12.21199989 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 37.30899811 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 41.80899811 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 48.36999893 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 52.86999893 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 57.84500122 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 62.34500122 27.3220005 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 106.83499908 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 111.33499908 27.3220005 Tm [(complex)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 147.81399536 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 152.31399536 27.3220005 Tm [(located)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 184.13499451 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 188.63499451 27.3220005 Tm [(on)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 199.90299988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 204.40299988 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 218.40400696 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 222.90400696 27.3220005 Tm [(th)1(in)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 239.73899841 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 244.23899841 27.3220005 Tm [(fila)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(men)-1(t)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 22.43799973 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 26.93799973 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 35.77999878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 40.27999878 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 54.28099823 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 58.78099823 42.92200089 Tm [(sar)1(c)-1(omere.)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 105.84200287 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 110.34200287 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 127.60399628 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 132.10400391 42.92200089 Tm [(complex)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 168.58299255 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 173.08299255 42.92200089 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 212.92399597 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 217.42399597 42.92200089 Tm [(st)1(riated)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 249.96600342 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 30.15999985 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 34.65999985 58.52199936 Tm [(contractio)1(n)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 83.73400116 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 88.23400116 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 96.17500305 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 100.67500305 58.52199936 Tm [(response)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 139.67199707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 144.17199707 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 153.24699402 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 157.74699402 58.52199936 Tm [(fluctuatio)1(n)-1(s)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 208.37600708 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 212.87600708 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 220.81700134 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 225.31700134 58.52199936 Tm [(intra)1(c)-1(ell)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ular)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 16.35199928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 20.85199928 74.12200165 Tm [(calc)-1(ium)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 53.62200165 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 58.12200165 74.12200165 Tm [(conc)-1(entrat)1(ion.)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 120.01499939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 124.51499939 74.12200165 Tm [(This)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 141.7769928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 146.2769928 74.12200165 Tm [(complex)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 182.7559967 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 187.2559967 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 193.81700134 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 198.31700134 74.12200165 Tm [(composed)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 243.48399353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 247.98399353 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 256.82598877 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 22.54400063 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 27.04400063 89.72200012 Tm [(subunits:)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 65.6760025 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 70.1760025 89.72200012 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 107.64399719 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 112.14399719 89.72200012 Tm [(C,)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 120.33100128 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 124.83100128 89.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 149.92799377 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 154.42799377 89.72200012 Tm [(binds)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 178.03999329 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 182.53999329 89.72200012 Tm [(calc)-1(ium,)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 217.477005 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 221.977005 89.72200012 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 259.44500732 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(T,)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 7.32600021 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 11.82600021 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 36.92300034 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 41.42300034 105.3219986 Tm [(binds)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 65.03500366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 69.53500366 105.3219986 Tm [(tr)1(opomyos)1(i)-1(n,)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 126.70800018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 131.20799255 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 147.48500061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 151.98500061 105.3219986 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 189.45300293 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 193.95300293 105.3219986 Tm [(I,)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 198.76499939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 203.26499939 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 228.36199951 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 232.86199951 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 239.42300415 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 243.92300415 105.3219986 Tm [(an)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 254.44400024 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 258.94400024 105.3219986 Tm [(i)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(nhibit)1(ory)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 38.90000153 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 43.40000153 120.92199707 Tm [(subunit.)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 77.86599731 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 82.36599731 120.92199707 Tm [(This)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 99.62799835 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 104.12799835 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 135.43499756 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 139.93499756 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 146.4960022 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 150.9960022 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 164.99699402 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 169.49699402 120.92199707 Tm [(slow)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 188.88600159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 193.38600159 120.92199707 Tm [(ske)-1(leta)1(l)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 225.78199768 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 230.28199768 120.92199707 Tm [(tr)1(opon)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 7.94099998 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 12.44099998 136.52200317 Tm [(T)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 17.60000038 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 22.10000038 136.52200317 Tm [(subunit.)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 56.56600189 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 61.06600189 136.52200317 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 104.91500092 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 109.41500092 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 117.35600281 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 121.85600281 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 137.31199646 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 141.81199646 136.52200317 Tm [(gene)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 163.32800293 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 167.82800293 136.52200317 Tm [(cause)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 192.13400269 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 196.63400269 136.52200317 Tm [(ne)-1(ma)1(li)-1(ne)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 236.13600159 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 240.63600159 136.52200317 Tm [(myo)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(pa)1(thy)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 24.38100052 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 28.88100052 152.12199402 Tm [(type)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 47.85200119 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 52.35200119 152.12199402 Tm [(5,)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 59.79600143 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 64.29599762 152.12199402 Tm [(also)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 81.5530014 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 86.0530014 152.12199402 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 114.87200165 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 119.37200165 152.12199402 Tm [(as)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 128.51300049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 133.01300049 152.12199402 Tm [(Amish)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 159.8809967 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 164.3809967 152.12199402 Tm [(ne)-1(ma)1(li)-1(ne)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 203.88299561 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 208.38299561 152.12199402 Tm [(myopa)1(thy,)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 253.84899902 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 4.9749999 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 9.47500038 167.72200012 Tm [(ne)-1(uro)1(mu)-1(s)1(c)-1(ular)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 73.84200287 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 78.34200287 167.72200012 Tm [(diso)1(rder)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 114.11799622 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 118.61799622 167.72200012 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 176.15100098 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 180.65100098 167.72200012 Tm [(by)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 191.16299438 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 195.66299438 167.72200012 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 225.82299805 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 230.32299805 167.72200012 Tm [(weakn)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 153.8500061 0.75 m 153.8500061 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17501831 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
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