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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.63200378 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 151.39599609 23.67700005 Tm 0 Tr [(S1)1(00A6)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 225.227005 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 335.66699219 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(S100A6)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.93699646 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.43699646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.93699646 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(S100A)1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.91999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.29399872 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.06599426 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44000244 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.76100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.13499451 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.93099976 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(S100)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.79000092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.16400146 12.82499981 Tm [(calci)-1(um)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.79699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.17099762 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.99899292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.3730011 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.75500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.1289978 12.82499981 Tm [(A6)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.33599854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.71000671 12.82499981 Tm [(2A)1(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.23899841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.61300659 12.82499981 Tm [(PRA)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.6230011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.99699402 12.82499981 Tm [(5B10)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.48300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.85699463 12.82499981 Tm [(CABP)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.47601318 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.8500061 12.82499981 Tm [(CACY)] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.23901367 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 145.7749939 187.94999695 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 278.0249939 -0.25 l 278.0249939 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(S1)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.86000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.36000061 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.20199966 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.70199966 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.17500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.67500305 27.3220005 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42199707 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.92199707 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.19999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.69999695 27.3220005 Tm [(EF-h)1(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.14199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.64199829 27.3220005 Tm [(calc)-1(ium-b)1(i)-1(nd)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.44900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mot)1(ifs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.35499954 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.85499954 42.92200089 Tm [(S1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.88299942 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.38299942 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.85600281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.35600281 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.87400055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.37400055 42.92200089 Tm [(localized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.05700684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.55700684 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.4980011 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.9980011 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.99899292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.49899292 42.92200089 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.56700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.06700134 42.92200089 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.34799194 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.81800079 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.31800079 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.15999985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.65999985 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.63499832 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.13499832 58.52199936 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.49900055 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.99900055 58.52199936 Tm [(rang)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.81900024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.31900024 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.16100311 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.66100311 58.52199936 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.40299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.90299988 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.17999268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.67999268 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.04899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.54899597 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.49000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.99000549 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.99099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.49099731 58.52199936 Tm [(regul)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.98999977 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.48999977 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.33200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.83200073 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.80699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.30699921 74.12200165 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.1230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.6230011 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.46499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.96499634 74.12200165 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.727005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.227005 74.12200165 Tm [(pro)1(c)-1(esses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.35699463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.85699463 74.12200165 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.62399292 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.12399292 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.26499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.76499939 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.17500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.67500305 74.12200165 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.9670105 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pro)1(gression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.20100021 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.70100021 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.97799683 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.47799683 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.97000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.47000122 89.72200012 Tm [(S1)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.4980011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.9980011 89.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.67999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.17999268 89.72200012 Tm [(inc)-1(lude)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.43800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.93800354 89.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.26600647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.76600647 89.72200012 Tm [(least)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.76098633 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.55599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.05599976 105.3219986 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.48600006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.98600006 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.08300018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.58300018 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.10099792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.60099792 105.3219986 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42199707 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.92199707 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.06300354 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.56300354 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.53799438 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.03799438 105.3219986 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.55400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.05400085 105.3219986 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.32200623 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.82200623 105.3219986 Tm [(chromos)1(om)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(1q21)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.36299896 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.86299896 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.125 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.625 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.93199921 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.43199921 120.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.60299683 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.10299683 120.92199707 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.84399414 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.34399414 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.28500366 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.78500366 120.92199707 Tm [(st)1(i)-1(mulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.06300354 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.56300354 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.40499878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.90499878 120.92199707 Tm [(Ca2+-)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(epen)-1(d)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.26900101 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.76900101 136.52200317 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.75800323 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.25800323 136.52200317 Tm [(rele)-1(a)1(se)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.71600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.21600342 136.52200317 Tm [(st)1(i)-1(mulat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.4940033 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.9940033 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.83599854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.33599854 136.52200317 Tm [(pro)1(lac)-1(t)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.41900635 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.91900635 136.52200317 Tm [(sec)-1(retio)1(n)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.42999268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 152.12199402 Tm [(exocy)-1(t)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.41200256 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.91200256 152.12199402 Tm [(Chro)1(mosoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.477005 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.977005 152.12199402 Tm [(rearra)1(n)-1(g)1(e)-1(ments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.35600281 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.85600281 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.13299561 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.63299561 152.12199402 Tm [(alt)1(e)-1(red)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.76199341 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.95399857 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.45399857 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.29600143 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.79600143 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.2519989 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.7519989 167.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.26799774 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.76799774 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.11500549 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.61500549 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.12199402 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.62199402 167.72200012 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.69200134 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.19200134 167.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.13299561 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.63299561 167.72200012 Tm [(mel)-1(a)1(noma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 145.0249939 0.75 l 145.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.0249939 -0.25 l 146.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 145.7749939 16.35000038 l h f* Q q 1 0 0 1 145.3999939 0 cm -0.625 -0.25 m 278.0249939 -0.25 l 278.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 0.75 m 145.3999939 187.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.3999939 188.69999695 m 145.3999939 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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