%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 134 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(TNN)1(I3\()1(P)-1(h)1(osp)1(ho-Thr142\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.53500366 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 281.53500366 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 391.9750061 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(TNN)1(I3\(Pho)-1(sph)-1(o-Th)-1(r)1(142\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.76100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 185.01100159 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 237.51100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.76100159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TN)1(NI3\(Phosp)-1(ho)-1(-Thr142\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.36999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.7440033 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.39399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.76800537 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.32699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.70098877 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.49700928 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CMH7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.24900055 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.6230011 12.82499981 Tm [(RCM1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.03099823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.40499878 12.82499981 Tm [(cTn)-1(I;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.93299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.30700684 12.82499981 Tm [(CMD2A;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55000305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92399597 12.82499981 Tm [(TNN)1(C)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.32600403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.69999695 12.82499981 Tm [(CMD1F)-1(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.70700073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNN)1(I3\(Pho)-1(sph)-1(o-Th)-1(r)1(142\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.63600159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.102005 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 184.2250061 0.75 l 184.2250061 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 185.2250061 -0.25 l 185.2250061 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 184.9750061 0.75 m 422.375 0.75 l 422.375 172.3500061 l 184.9750061 172.3500061 l h f* Q q 1 0 0 1 184.6000061 0 cm -0.625 -0.25 m 238.7749939 -0.25 l 238.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Trop)1(oni)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.27399826 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.77399826 11.72200012 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.41999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.91999817 11.72200012 Tm [(\(TnI\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.4489975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.9489975 11.72200012 Tm [(along)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.34300232 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.84300232 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.23899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.73899841 11.72200012 Tm [(tr)1(oponin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.20700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.70700073 11.72200012 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.86599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.36599731 11.72200012 Tm [(\(TnT)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.24200439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.74200439 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tr)1(oponin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.4679985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.9679985 27.3220005 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.98899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.48899841 27.3220005 Tm [(\(TnC\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.39299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.89299774 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.45400238 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.95400238 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.32800293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.82800293 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.66999817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.16999817 27.3220005 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.94799805 27.3220005 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.41400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.91400146 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.13600159 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.63600159 27.3220005 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.84700012 27.3220005 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 42.92200089 Tm [(tr)1(oponin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.61600113 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.11600113 42.92200089 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.59500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.09500122 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.93699646 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.43699646 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.43800354 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.93800354 42.92200089 Tm [(th)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.772995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.272995 42.92200089 Tm [(filaments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.76199341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.26199341 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.10400391 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.60400391 42.92200089 Tm [(st)1(riat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 58.52199936 Tm [(musc)-1(le.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.68899918 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.18899918 58.52199936 Tm [(TnI)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.54000092 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.04000092 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.60099792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.10099792 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.10199738 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.60199738 58.52199936 Tm [(inhibito)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.89700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.39700317 58.52199936 Tm [(subunit;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.86300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.36300659 58.52199936 Tm [(blocki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.33900452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(actin-myosin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.70100021 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.20100021 74.12200165 Tm [(interactions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.70700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.20700073 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.48399353 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.98399353 74.12200165 Tm [(th)1(e)-1(r)1(e)-1(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.03999329 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.53999329 74.12200165 Tm [(mediat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.25700378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.75700378 74.12200165 Tm [(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(riat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.02199936 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.52199936 89.72200012 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.68199921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.18199921 89.72200012 Tm [(relaxat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.81300354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.31300354 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.11999512 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.61999512 89.72200012 Tm [(TnI)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.97099304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.47099304 89.72200012 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.01300049 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.51300049 89.72200012 Tm [(contain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.20999908 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.70999908 105.3219986 Tm [(gene)-1(s:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.55799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.05799866 105.3219986 Tm [(TnI-ske)-1(letal-)1(fast)1(-t)1(witch,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.52799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.02799988 105.3219986 Tm [(TnI-ske)-1(letal-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(slow)1(-t)1(witch,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.70999908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.20999908 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.48699951 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.98699951 120.92199707 Tm [(TnI-cardiac.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.96199799 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.46200562 120.92199707 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.72399902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.22399902 120.92199707 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.74000549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.24000549 120.92199707 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.15699768 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.65699768 120.92199707 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 136.52200317 Tm [(TnI-cardiac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.41400146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.91400146 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.22100067 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.72100067 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.9980011 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.4980011 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.05899811 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.55900574 136.52200317 Tm [(exc)-1(lusively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.23100281 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.73100281 136.52200317 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.88499451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.38499451 136.52200317 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 152.12199402 Tm [(cardiac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.61000061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.11000061 152.12199402 Tm [(musc)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.26999664 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.76999664 152.12199402 Tm [(tiss)1(u)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.83499908 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.33499908 152.12199402 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.18400574 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.68400574 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.625 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.125 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.58099365 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.08099365 152.12199402 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.59700012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.09700012 152.12199402 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.79299927 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.29299927 167.72200012 Tm [(fa)1(mi)-1(lia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.37599945 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.87599945 167.72200012 Tm [(hypert)1(roph)1(i)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.18099976 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.68099976 167.72200012 Tm [(cardiomyop)1(ath)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.77799988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.27799988 167.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.24899292 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.74899292 167.72200012 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.0269928 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.5269928 167.72200012 Tm [(\()] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 184.6000061 0.75 m 184.6000061 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.125 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> 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