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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 88.00700378 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 137.68299866 23.67700005 Tm 0 Tr [(YWHAQ)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 216.85299683 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 327.29299927 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(YWHAQ)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.88999939 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.38999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.13999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(YWHA)1(Q)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.87400055 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.2480011 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.897995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.27200317 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.83099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.20500183 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.00100708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(1C5,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.86199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.23600006 12.82499981 Tm [(HS)-1(1)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.54399872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.91799927 12.82499981 Tm [(14-3-3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.63400269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(YWHAQ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.13999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 149.9750061 0.75 l 149.9750061 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 150.9750061 -0.25 l 150.9750061 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.7250061 0.75 m 422.42501831 0.75 l 422.42501831 141.1499939 l 150.7250061 141.1499939 l h f* Q q 1 0 0 1 150.3500061 0 cm -0.625 -0.25 m 273.07501221 -0.25 l 273.07501221 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.85299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.35299683 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.79299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.29299927 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.86799622 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.8690033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.3690033 11.72200012 Tm [(14)-1(-)1(3)-1(-3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.26699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.76699829 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.84899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.34899902 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.19099426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.69099426 11.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.71199989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.21199989 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.30899811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.80899811 27.3220005 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.93399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.43399811 27.3220005 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.66699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.16699982 27.3220005 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.4750061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.9750061 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.48699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.98699951 27.3220005 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.1309967 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.6309967 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.70599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.20599365 27.3220005 Tm [(ph)1(os)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ph)1(oserin)-1(e-conta)1(in)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.40799713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.90799713 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.54699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.04699707 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.30900574 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.80900574 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.20300293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.70300293 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.77999878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.27999878 42.92200089 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.52299881 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.02299881 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58399963 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08399963 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.77400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.27400208 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.21499634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.71499634 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.07900238 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.57900238 58.52199936 Tm [(plant)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.76199341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.26199341 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.53900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.03900146 58.52199936 Tm [(mammals,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.01499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.51499939 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.79200745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.29200745 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.74798584 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.36800003 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.86800003 74.12200165 Tm [(99)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.43000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.93000031 74.12200165 Tm [(identical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.36499786 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.86499786 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.94000244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.44000244 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.44099426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.94099426 74.12200165 Tm [(mouse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.91400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.41400146 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.69099426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.19099426 74.12200165 Tm [(rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.95500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.45500183 74.12200165 Tm [(ort)1(holo)1(gs.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.43499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 89.72200012 Tm [(upregulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.56500244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.06500244 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.0059967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.5059967 89.72200012 Tm [(pa)1(tien)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.147995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.647995 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.04400635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.54400635 89.72200012 Tm [(amyot)1(roph)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.14599609 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.64599609 89.72200012 Tm [(lat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(eral)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.91300011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.41300011 105.3219986 Tm [(scle)-1(ro)1(sis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.64500046 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.14500046 105.3219986 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.14399719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.64399719 105.3219986 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.85900116 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.35900116 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.30000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.80000305 105.3219986 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.71400452 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.21400452 105.3219986 Tm [(5')] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.79899597 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.29899597 105.3219986 Tm [(UTR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.05299377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.55299377 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.52799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.02799988 105.3219986 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.30599976 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80599976 105.3219986 Tm [(bp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.30200195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.80200195 105.3219986 Tm [(ta)1(n)-1(d)1(e)-1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.97200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.47200012 105.3219986 Tm [(rep)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(eat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.43400002 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.93400002 120.92199707 Tm [(seque)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.78099823 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.28099823 120.92199707 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.37799835 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.87799835 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.43900299 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.93900299 120.92199707 Tm [(po)1(l)-1(ymor)1(phic,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.522995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.022995 120.92199707 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.93200684 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.43200684 120.92199707 Tm [(th)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.47599792 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.03700256 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.53700256 120.92199707 Tm [(no)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.80499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(correlation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.59999847 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.09999847 136.52200317 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.17199707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.67199707 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.67299652 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.17299652 136.52200317 Tm [(repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.897995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.397995 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.21400452 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.71400452 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.99099731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.49099731 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.49200439 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.99200439 136.52200317 Tm [(disease.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.83000183 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 149.9750061 0.75 l 149.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.9750061 -0.25 l 150.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.7250061 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 150.7250061 16.35000038 l h f* Q q 1 0 0 1 150.3500061 0 cm -0.625 -0.25 m 273.07501221 -0.25 l 273.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 149.9750061 0.75 l 149.9750061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 150.9750061 -0.25 l 150.9750061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 150.7250061 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 150.7250061 16.35000038 l h f* Q q 1 0 0 1 150.3500061 0 cm -0.625 -0.25 m 273.07501221 -0.25 l 273.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(YW)1(H)-1(A)1(Q)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.2179985 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.3500061 0.75 m 150.3500061 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.3500061 141.8999939 m 150.3500061 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 150.3500061 158.25 m 150.3500061 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42501831 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42501831 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 174.2250061 m 423.17501831 174.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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