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12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(K)1(DM2B)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 115.65899658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 118.03299713 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 143.68299866 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 146.05700684 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 189.61599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 191.99000549 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 229.78599548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(lysi)-1(ne)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 87.41999817 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 89.79399872 12.82499981 Tm [(deme)1(th)-1(y)1(l)-1(ase)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 144.70399475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 147.07800293 12.82499981 Tm [(2B;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 160.92100525 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 163.29499817 12.82499981 Tm [(CXXC2;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 193.52400208 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 195.897995 12.82499981 Tm [(Fb)-1(l10;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 222.102005 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 224.47599792 12.82499981 Tm [(PCCX2;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 254.67900085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 257.05300903 12.82499981 Tm [(FBXL)-1(10;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 290.90600586 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 293.27999878 12.82499981 Tm [(JHDM1B)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 329.64001465 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(KDM2B)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 94.9260025 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 84 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 127.42500305 0.75 l 127.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 128.42500305 -0.25 l 128.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 128.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 128.17500305 156.75 l h f* Q q 1 0 0 1 127.80000305 0 cm -0.625 -0.25 m 295.625 -0.25 l 295.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(F-bo)1(x)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 194.98300171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 199.48300171 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 230.78999329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 235.28999329 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 261.37200928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 265.87200928 11.72200012 Tm [(wh)1(ic)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(h)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 5.54199982 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 10.04199982 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 16.60300064 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 21.10300064 27.3220005 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 78.63600159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 83.13600159 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 93.64800262 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 98.14800262 27.3220005 Tm [(an)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 108.66899872 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 113.16899872 27.3220005 Tm [(ap)1(prox)1(i)-1(ma)1(tely)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 174.77999878 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 179.27999878 27.3220005 Tm [(40)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 189.83599854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 194.33599854 27.3220005 Tm [(amino)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 221.40600586 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 225.90600586 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 243.54600525 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 248.04600525 27.3220005 Tm [(mot)1(if,)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 273.23498535 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 277.73498535 27.3220005 Tm [(th)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(F-bo)1(x.)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 36.47900009 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 40.97900009 42.92200089 Tm [(The)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 56.7859993 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 61.2859993 42.92200089 Tm [(F-bo)1(x)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 85.99199677 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 90.49199677 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 125.96499634 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 130.46499634 42.92200089 Tm [(constitut)1(e)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 173.51800537 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 178.01800537 42.92200089 Tm [(one)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 194.39199829 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 198.89199829 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 207.73399353 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 212.23399353 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 226.23500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 230.73500061 42.92200089 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 248.55900574 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 253.05900574 42.92200089 Tm [(subunit)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(s)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 4.16599989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 8.66600037 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 17.50799942 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 22.00799942 58.52199936 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 60.68899918 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 65.18900299 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 96.4960022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 100.9960022 58.52199936 Tm [(ligase)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 125.79000092 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 130.28999329 58.52199936 Tm [(complex)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 166.76899719 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 171.26899719 58.52199936 Tm [(calle)-1(d)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 196.41000366 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 200.91000366 58.52199936 Tm [(SCFs)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 221.07200623 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 225.57200623 58.52199936 Tm [(\(SKP1-cul)-1(lin-F)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(-b)1(ox\),)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 25.09700012 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 29.59700012 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 54.69400024 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 59.19400024 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 94.93499756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 99.43499756 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 107.37599945 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 111.87599945 74.12200165 Tm [(ph)1(osph)1(orylation-)1(depen)-1(d)1(e)-1(nt)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 233.56900024 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 238.06900024 74.12200165 Tm [(ubiquitinat)1(i)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(on.)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 13.43400002 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 17.93400002 89.72200012 Tm [(The)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 33.74100113 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 38.24100113 89.72200012 Tm [(F-bo)1(x)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 62.9469986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 67.4469986 89.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 102.91999817 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 107.41999817 89.72200012 Tm [(are)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 120.93800354 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 125.43800354 89.72200012 Tm [(divid)1(e)-1(d)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 157.32899475 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 161.82899475 89.72200012 Tm [(into)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 178.84500122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 183.34500122 89.72200012 Tm [(3)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 188.6230011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 193.1230011 89.72200012 Tm [(cl)-1(a)1(sses:)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 224.7769928 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 229.2769928 89.72200012 Tm [(Fbw)1(s)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 251.07800293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 255.57800293 89.72200012 Tm [(contai)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nin)-1(g)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 19.24399948 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 23.74399948 105.3219986 Tm [(WD)1(-40)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 54.20700073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 58.70700073 105.3219986 Tm [(do)1(mains,)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 97.86699677 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 102.36699677 105.3219986 Tm [(Fbls)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 119.45700073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 123.95700073 105.3219986 Tm [(containing)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 169.70399475 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 174.20399475 105.3219986 Tm [(leu)-1(cine)-1(-)1(ric)-1(h)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 224.59199524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 229.09199524 105.3219986 Tm [(repeats)1(,)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 263.1499939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 267.6499939 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 283.92700195 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(Fbxs)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 19.25699997 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 23.75699997 120.92199707 Tm [(containing)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 69.5039978 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 74.0039978 120.92199707 Tm [(either)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 98.94300079 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 103.44300079 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 140.38299561 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 144.88299561 120.92199707 Tm [(pro)1(tein)-1(-)1(pro)1(tein)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 211.38999939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 215.88999939 120.92199707 Tm [(interaction)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 262.23001099 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 266.73001099 120.92199707 Tm [(mod)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ule)-1(s)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 17.21299934 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 21.71299934 136.52200317 Tm [(or)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 30.87100029 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 35.37099838 136.52200317 Tm [(no)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 46.63899994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 51.13899994 136.52200317 Tm [(rec)-1(o)1(gnizable)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 106.26399994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 110.76399994 136.52200317 Tm [(mot)1(ifs.)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 140.1190033 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 144.6190033 136.52200317 Tm [(The)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 160.42599487 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 164.92599487 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 196.23300171 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 200.73300171 136.52200317 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 238.24000549 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 242.74000549 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 253.2519989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 257.75201416 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 273.20800781 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 277.70800781 136.52200317 Tm [(g)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(en)-1(e)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 15.75899982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 20.25900078 152.12199402 Tm [(belongs)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 54.69900131 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 59.19900131 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 68.27400208 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 72.77400208 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 86.77500153 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 91.27500153 152.12199402 Tm [(Fbls)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 108.36499786 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 112.86499786 152.12199402 Tm [(cl)-1(a)1(ss.)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 135.2460022 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 139.7460022 152.12199402 Tm [(Multiple)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 175.47799683 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 179.97799683 152.12199402 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 232.50100708 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 237.00100708 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 267.08200073 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 271.58200073 152.12199402 Tm [(tr)1(a)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 127.80000305 0.75 m 127.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 157.125 m 423.17498779 157.125 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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