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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 9.40100002 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 59.07699966 23.67700005 Tm 0 Tr [(PLCG)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.90200043 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.87599945 23.67700005 Tm [(\(Ph)1(osph)1(o-Tyr753\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.45901489 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 295.45901489 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 405.89898682 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(PLCG2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.00800323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.38200378 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr7)1(53\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.61500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 197.86500549 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 250.36500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.11499023 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(P)1(L)-1(CG2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.48999786 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr7)1(53\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.7230072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.09700012 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.74699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.1210022 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.67999268 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.0539856 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.8500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FC)-1(A)1(S)-1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.45400238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.82800293 12.82499981 Tm [(AP)1(L)-1(A)1(ID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.92299652 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLCG2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.38300323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.75700378 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr7)1(53\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.99000549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 140.5249939 0.75 l 140.5249939 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 141.5249939 -0.25 l 141.5249939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.2749939 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 141.2749939 78.75 l h f* Q q 1 0 0 1 140.8999939 0 cm -0.625 -0.25 m 282.5249939 -0.25 l 282.5249939 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(duc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.54499817 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.38700104 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.88700104 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.88800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.38800049 11.72200012 Tm [(sec)-1(o)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.19799805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.69799805 11.72200012 Tm [(messe)-1(ng)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.52200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.02200317 11.72200012 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.40499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.90499878 11.72200012 Tm [(dia)1(c)-1(ylgl)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(yc)-1(erol.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.10300064 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.60300064 27.3220005 Tm [(\(DA)1(G\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.49599838 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.99599838 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.27300262 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.77300262 27.3220005 Tm [(inosito)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.46600342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.96600342 27.3220005 Tm [(1,4)-1(,)1(5)-1(-)1(trisp)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.77799988 27.3220005 Tm [(\(IP3\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.21899414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.71899414 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.27999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.77999878 27.3220005 Tm [(mediat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.375 42.92200089 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.52600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.02600098 42.92200089 Tm [(ph)1(osph)1(atid)1(y)-1(linosito)1(l-speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.67500305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.17500305 42.92200089 Tm [(ph)1(osph)1(olipase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.14898682 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.02099991 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.52099991 58.52199936 Tm [(en)-1(z)1(y)-1(mes.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.23400116 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.73400116 58.52199936 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.73300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.23300171 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.79399872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.29399872 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.26899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.76899719 58.52199936 Tm [(cru)-1(cial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.54199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.04199982 58.52199936 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.42300415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.92300415 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.86399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.36399841 58.52199936 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.62399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.12399292 58.52199936 Tm [(signalin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(g.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.92299986 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q /GS2 gs 1 g 0.375 0.75 m 140.5249939 0.75 l 140.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.5249939 -0.25 l 141.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.2749939 16.35000038 l h f* Q q 1 0 0 1 140.8999939 0 cm -0.625 -0.25 m 282.5249939 -0.25 l 282.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.89900017 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 140.5249939 0.75 l 140.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.5249939 -0.25 l 141.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.2749939 16.35000038 l h f* Q q 1 0 0 1 140.8999939 0 cm -0.625 -0.25 m 282.5249939 -0.25 l 282.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PLCG2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.11599922 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.61600113 11.72200012 Tm [(\(Pho)1(spho)1(-Tyr7)-1(53)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.66100311 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 140.5249939 0.75 l 140.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.5249939 -0.25 l 141.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.2749939 16.35000038 l h f* Q q 1 0 0 1 140.8999939 0 cm -0.625 -0.25 m 282.5249939 -0.25 l 282.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Syn)-1(t)1(hetic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26599884 11.72200012 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48000336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98000336 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.8219986 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.3219986 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.36299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.86300659 11.72200012 Tm [(PLCG2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.97900391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.47900391 11.72200012 Tm [(\(Pho)1(spho)1(-Tyr7)-1(53)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.52400208 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q /GS2 gs 1 g 0.375 0.75 m 140.5249939 0.75 l 140.5249939 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 141.5249939 -0.25 l 141.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.2749939 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 141.2749939 31.95000076 l h f* Q q 1 0 0 1 140.8999939 0 cm -0.625 -0.25 m 282.5249939 -0.25 l 282.5249939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ph)1(osph)1(olipase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.97399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.47399902 11.72200012 Tm [(C,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.66100311 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.16100311 11.72200012 Tm [(ga)1(mma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.73300171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.23300171 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51100159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.01100159 11.72200012 Tm [(\(ph)1(osph)1(atid)1(y)-1(linosito)1(l-specific)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.67199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.17199707 11.72200012 Tm [(\(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ho)1(spho)1(-Ty)-1(r)1(7)-1(53)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.53299713 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 140.5249939 0.75 l 140.5249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.5249939 -0.25 l 141.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm [<0020>] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 55.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.2749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.2749939 16.35000038 l h f* Q q 1 0 0 1 140.8999939 0 cm -0.625 -0.25 m 282.5249939 -0.25 l 282.5249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(FCAS3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.77300072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.27299881 11.72200012 Tm [(AP)1(L)-1(A)1(ID)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.56400299 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.8999939 0.75 m 140.8999939 78.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.8999939 79.5 m 140.8999939 95.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.8999939 95.84999847 m 140.8999939 111.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.8999939 112.19999695 m 140.8999939 127.79999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.8999939 128.54998779 m 140.8999939 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.8999939 160.5 m 140.8999939 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 176.4750061 m 423.17498779 176.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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