%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 160 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 90.18699646 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 139.86300659 23.67700005 Tm 0 Tr [(YWHAE)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 214.67199707 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 325.11199951 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(YWHAE)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 121.45200348 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.95199585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.70199585 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(YWHA)1(E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.93599701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.30999756 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.96000671 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.33399963 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.89300537 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.26699829 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.06300354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(MDS)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.88200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.2559967 12.82499981 Tm [(MDCR,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.61299896 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.98699951 12.82499981 Tm [(KCIP)1(-1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.26699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.64100647 12.82499981 Tm [(14-3-3E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.48399353 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(YWHAE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.20200348 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 144.5249939 0.75 l 144.5249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 145.5249939 -0.25 l 145.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.2749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 145.2749939 172.3500061 l h f* Q q 1 0 0 1 144.8999939 0 cm -0.625 -0.25 m 278.5249939 -0.25 l 278.5249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.85299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.35299683 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.79299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.29299927 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.86799622 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.8690033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.3690033 11.72200012 Tm [(14)-1(-)1(3)-1(-3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.26699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.76699829 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.84899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.34899902 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.19099426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.69099426 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.16400146 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.09700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.59700012 27.3220005 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72200012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.22200012 27.3220005 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.45500183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.95500183 27.3220005 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.26300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.76300049 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.2749939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.7749939 27.3220005 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.91900635 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.41900635 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.4940033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.9940033 27.3220005 Tm [(ph)1(osph)1(os)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(erin)-1(e-conta)1(in)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.73100281 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.37000275 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.87000275 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.13200378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.63200378 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.02600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.52600098 42.92200089 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.60299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.10299683 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.41000366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.91000366 42.92200089 Tm [(fa)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.98699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.48699951 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.04800034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.54800034 58.52199936 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.23799896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.73799896 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.67900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.17900085 58.52199936 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.54299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.04299927 58.52199936 Tm [(plant)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.22599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.72599792 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.00300598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.50300598 58.52199936 Tm [(mammals,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.47900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.97900391 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.2559967 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.7559967 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.21200562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.71200562 58.52199936 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60700035 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.10700035 74.12200165 Tm [(10)-1(0%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.9469986 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.4469986 74.12200165 Tm [(identical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.88200378 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.38200378 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.45700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.95700073 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.95800018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.45800018 74.12200165 Tm [(mouse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.43099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93099976 74.12200165 Tm [(ort)1(holo)1(g.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.74499512 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.24499512 74.12200165 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.2440033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.7440033 74.12200165 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.58799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.08799744 74.12200165 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 89.72200012 Tm [(CDC25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.49399948 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.99399948 89.72200012 Tm [(ph)1(osph)1(ata)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.36799622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.86799622 89.72200012 Tm [(RA)1(F)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.13499451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.63499451 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.91200256 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.41200256 89.72200012 Tm [(IRS1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.40499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.90499878 89.72200012 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.54400635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.04400635 89.72200012 Tm [(sugg)1(e)-1(st)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.17099953 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.67099953 105.3219986 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.33100128 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.83100128 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.77199936 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.27199936 105.3219986 Tm [(diverse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.96299744 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.46299744 105.3219986 Tm [(biochemic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.19999695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.69999695 105.3219986 Tm [(activit)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.07499695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.57499695 105.3219986 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.70399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.20399475 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.27900696 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.77900696 105.3219986 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.01199341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tr)1(ansduc)-1(t)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.47399902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.97399902 120.92199707 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.74099731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.24099731 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.38200378 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.88200378 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.29199982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.79199982 120.92199707 Tm [(division)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.89199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.39199829 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.66900635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.16900635 120.92199707 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.3999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.8999939 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74200439 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.24200439 120.92199707 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.23098755 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(sensitivity.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.52999878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.02999878 136.52200317 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.02899933 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.52899933 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.21099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.71099854 136.52200317 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.96800232 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.46800232 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.97499847 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.47499847 136.52200317 Tm [(implicated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.54499817 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.04499817 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.98599243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.48599243 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.48699951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.98699951 136.52200317 Tm [(pa)1(tho)1(gen)-1(esis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.56900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.84200001 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.34200001 152.12199402 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.70600128 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.20600128 152.12199402 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.61600113 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.11600113 152.12199402 Tm [(lun)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.36000061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.86000061 152.12199402 Tm [(canc)-1(er.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.11599731 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.61599731 152.12199402 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.60299683 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.10299683 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.0249939 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.5249939 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.26100159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.76100159 152.12199402 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.13499451 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.63499451 152.12199402 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(in-coding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.52399826 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.02399826 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.30099869 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.8010025 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.80200195 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.30200195 167.72200012 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.46099854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.96099854 167.72200012 Tm [(non-p)1(rotein-coding,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.72399902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.22399902 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.57099915 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.07099915 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.57800293 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.07800293 167.72200012 Tm [(fo)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.8999939 0.75 m 144.8999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>