%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 134 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 97.12200165 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABF 22 Tf 1 0 0 -1 146.79800415 23.67700005 Tm [(Y)-4(W)-4(H)-4(A)-4(B)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 207.73800659 23.67700005 Tm [<0009>-4<000A>-4<000B>-4<0004>-4<000C>] TJ ET EMC /P <> BDC BT /FAAABF 22 Tf 1 0 0 -1 318.17800903 23.67700005 Tm 1 Tr /GS1 gs 0 G [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<000D000E000F00100011>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(YWHAB)] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 111.53700256 12.82499981 Tm [<0009000A000B0004000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.03700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.53700256 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<0012000E000F00100011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(Anti-)-1(YWHA)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.51999664 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.89399719 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.54400635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.91799927 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.477005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.85099792 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT /FAAAAH 22 Tf 1 0 0 -1 230.64700317 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<0013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000F0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(HS)-1(1)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.30799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.68199921 12.82499981 Tm [(GW1)1(28,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.23300171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.60700226 12.82499981 Tm [(YWHAA)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.37800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.7519989 12.82499981 Tm [(KCIP)1(-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.41200256 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<00140015001600130011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [<00170004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<00190011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [<001A001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001D001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<00200011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<00210011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(YWHAB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.78700256 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<00220023002400250011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<0026002700280011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABI 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 Tr [<000A000B001600290011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS1 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q /GS1 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS1 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACE 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0 Tr /GS1 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACI 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS2 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS1 gs 1 g 0.375 0.75 m 193.625 0.75 l 193.625 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 194.625 -0.25 l 194.625 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 89.72200012 Tm 0 Tr /GS1 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS2 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 1 g 194.375 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 194.375 172.3500061 l h f* Q q 1 0 0 1 194 0 cm -0.625 -0.25 m 229.42500305 -0.25 l 229.42500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 0 11.72200012 Tm 0 Tr /GS1 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(belonging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.44900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.94900513 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.02400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.52400208 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.5249939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.0249939 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(4-3-3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.62100029 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.12100029 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.20299911 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.70299911 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.54499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.04499817 27.3220005 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.68399811 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.18399811 27.3220005 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.61399841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.11399841 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.95599365 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.45599365 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.55299377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.05299377 27.3220005 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(dia)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58600044 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08600044 42.92200089 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.31900024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.81900024 42.92200089 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1269989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.6269989 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.13899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63900757 42.92200089 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.78300476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.28300476 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.35800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.85800171 42.92200089 Tm [(ph)1(osph)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(serine)-1(-)1(c)-1(ont)1(aini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.39700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.89700317 58.52199936 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.53600311 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.03600311 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.29800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.79800415 58.52199936 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.19200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.69200134 58.52199936 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.76899719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 74.12200165 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.88899994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.38899994 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.94999695 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.44999695 74.12200165 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.13999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.63999939 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.58100128 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.08100128 74.12200165 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.44500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.94500732 74.12200165 Tm [(plant)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.12800598 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.62800598 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.90499878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.40499878 74.12200165 Tm [(mam)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(mals.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.13500023 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.63500023 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.44200134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.94200134 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.4489975 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.9489975 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.2559967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.7559967 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.43800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.93800354 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.44500732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.94500732 89.72200012 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.02600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.52600098 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.60099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.10099792 89.72200012 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nteract)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28300095 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.78300095 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.17900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.67900085 105.3219986 Tm [(RA)1(F)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.94599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.44599915 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.72299957 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.22299957 105.3219986 Tm [(CDC25)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.67500305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.17500305 105.3219986 Tm [(ph)1(osph)1(ata)1(se)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.54899597 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.04899597 105.3219986 Tm [(sug)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(gest)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.08000183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.58000183 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.80199814 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.30199814 120.92199707 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.05000305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.55000305 120.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.72100067 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.22100067 120.92199707 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.10199738 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.60199738 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.57700348 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.07700348 120.92199707 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.73699951 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.23699951 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.17799377 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.67799377 120.92199707 Tm [(link)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.61199951 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.11199951 120.92199707 Tm [(mito)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.45400047 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.95400047 136.52200317 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.88499832 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.38499832 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.66200256 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.16200256 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.16300201 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.66300201 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.07299805 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.57299805 136.52200317 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.86500549 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.36500549 136.52200317 Tm [(machine)-1(r)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.24099731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.74099731 136.52200317 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.72799683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.92200089 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.42200089 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.15799713 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.65799713 152.12199402 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.75499725 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.25499725 152.12199402 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.00500488 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.50500488 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.5059967 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.0059967 152.12199402 Tm [(same)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.68600464 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.18600464 152.12199402 Tm [(pro)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(in,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.10700035 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.60700035 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.95399857 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.45399857 167.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.96099854 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.46099854 167.72200012 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.39199829 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.89199829 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.16999817 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.66999817 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.12600708 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.62600708 167.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.30799866 167.72200012 Tm /GS2 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS1 gs 1 g 0.375 0.75 m 193.625 0.75 l 193.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.625 -0.25 l 194.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm 0 Tr /GS1 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS2 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 1 g 194.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 194.375 16.35000038 l h f* Q q 1 0 0 1 194 0 cm -0.625 -0.25 m 229.42500305 -0.25 l 229.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 0 11.72200012 Tm 0 Tr /GS1 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS2 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 188.69999695 cm q /GS1 gs 1 g 0.375 0.75 m 193.625 0.75 l 193.625 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 194.625 -0.25 l 194.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm 0 Tr /GS1 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS2 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 1 g 194.375 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 194.375 16.35000038 l h f* Q q 1 0 0 1 194 0 cm -0.625 -0.25 m 229.42500305 -0.25 l 229.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADB 9 Tf 1 0 0 -1 0 11.72200012 Tm 0 Tr /GS1 gs 0.13333334 g [(YW)1(H)-1(A)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.52999878 11.72200012 Tm /GS2 gs 0 g [( )] TJ ET EMC Q Q Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 205.05001831 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 194 0.75 m 194 172.3500061 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 194 173.1000061 m 194 188.70001221 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 194 189.45001221 m 194 205.05001831 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 205.05001831 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.07501221 m 422.42498779 189.07501221 l S Q q /GS3 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 205.42501831 m 423.17498779 205.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>