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[<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(PLCG1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.63300323 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.13299561 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 179.63299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(P)1(L)-1(CG1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 111.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 113.48999786 12.82499981 Tm [(\(Ab-783\))] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 150.63000488 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 153.0039978 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 178.65400696 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 181.02799988 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 224.58700562 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 226.96099854 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 264.75698853 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLC1;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 86.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 88.94300079 12.82499981 Tm [(NCK)1(AP)1(3;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 126.40599823 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 128.77999878 12.82499981 Tm [(PLC-II;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 155.53199768 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 157.90600586 12.82499981 Tm [(PLC148;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 192.11799622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 194.49200439 12.82499981 Tm [(PLCgamma1)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 247.02799988 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLCG1)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 90.38300323 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 82 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 88 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 89 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 91 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 151.0249939 0.75 l 151.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 152.0249939 -0.25 l 152.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 151.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 151.7749939 172.3500061 l h f* Q q 1 0 0 1 151.3999939 0 cm -0.625 -0.25 m 272.0249939 -0.25 l 272.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 197.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 202.2769928 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 216.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 220.77799988 11.72200012 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 263.48001099 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(inosito)1(l)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 45.03499985 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 49.53499985 27.3220005 Tm [(1,4)-1(,)1(5)-1(-)1(trisp)1(hosp)1(hat)1(e)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 132.84700012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 137.34700012 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 153.62399292 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 158.12399292 27.3220005 Tm [(dia)1(c)-1(ylglyc)-1(erol)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 217.01100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 221.51100159 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 242.22200012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 246.72200012 27.3220005 Tm [(ph)1(o)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(sph)1(atid)1(y)-1(linosit)1(ol)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 70.78700256 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 75.28700256 42.92200089 Tm [(4,5)-1(-)1(bisph)1(osph)1(ate.)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 152.27900696 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 156.77900696 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 174.04100037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 178.54100037 42.92200089 Tm [(reaction)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 213.58700562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 218.08700562 42.92200089 Tm [(uses)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 237.07099915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 241.57099915 42.92200089 Tm [(calc)-1(i)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(um)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 13.97900009 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 18.47900009 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 27.62000084 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 32.11999893 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 37.09500122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 41.59500122 58.52199936 Tm [(cofacto)1(r)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 76.9489975 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 81.4489975 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 97.72599792 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 102.22599792 58.52199936 Tm [(plays)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 124.27300262 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 128.772995 58.52199936 Tm [(an)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 139.29400635 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 143.79400635 58.52199936 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 186.75500488 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 191.25500488 58.52199936 Tm [(role)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 207.91499329 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 212.41499329 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 220.35600281 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 224.85600281 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 238.85699463 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 243.35699463 58.52199936 Tm [(intra)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 30.76199913 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 35.26200104 74.12200165 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 89.56999969 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 94.06999969 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 102.91200256 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 107.41200256 74.12200165 Tm [(rec)-1(ept)1(or-)1(m)-1(edia)1(ted)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 188.61000061 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 193.11000061 74.12200165 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 227.5980072 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 232.0980072 74.12200165 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 259.18600464 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(activat)1(ors.)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 43.77799988 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 48.27799988 89.72200012 Tm [(For)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 62.21699905 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 66.71700287 89.72200012 Tm [(example,)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 105.20899963 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 109.70899963 89.72200012 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 133.00900269 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 137.50900269 89.72200012 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 176.66000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 181.16000366 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 191.67199707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 196.17199707 89.72200012 Tm [(SRC,)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 215.42900085 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 219.92900085 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 233.92999268 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 238.42999268 89.72200012 Tm [(en)-1(co)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ded)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 16.62000084 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 21.12000084 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 52.42699814 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 56.92699814 105.3219986 Tm [(cause)-1(s)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 85.39900208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 89.89900208 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 103.90000153 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 108.40000153 105.3219986 Tm [(Ras)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 123.41600037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 127.91600037 105.3219986 Tm [(guanine)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 162.78700256 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 167.28700256 105.3219986 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 212.72599792 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 217.22599792 105.3219986 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 258.33200073 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 25.11899948 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 29.61899948 120.92199707 Tm [(Ras)1(GRP1)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 67.98799896 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 72.48799896 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 81.56300354 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 86.06300354 120.92199707 Tm [(tr)1(ansloc)-1(a)1(te)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 133.60299683 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 138.10299683 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 147.17799377 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 151.67799377 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 165.67900085 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 170.17900085 120.92199707 Tm [(Go)1(l)-1(g)1(i,)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 195.30700684 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 199.80700684 120.92199707 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 226.10400391 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 230.60400391 120.92199707 Tm [(it)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 236.352005 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 240.852005 120.92199707 Tm [(activ)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(at)1(e)-1(s)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 17.60000038 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 22.10000038 136.52200317 Tm [(Ras)1(.)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 39.28300095 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 43.78300095 136.52200317 Tm [(Also)1(,)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 64.56500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 69.06500244 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 84.52100372 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 89.02100372 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 120.32800293 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 124.82800293 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 139.50999451 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 144.00999451 136.52200317 Tm [(been)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 165.51699829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 170.01699829 136.52200317 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 198.0980072 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 202.5980072 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 211.67300415 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 216.17300415 136.52200317 Tm [(be)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 227.0269928 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 231.5269928 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 236.5019989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 241.0019989 136.52200317 Tm [(majo)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(r)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 3.43700004 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 7.9369998 152.12199402 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 47.78699875 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 52.28699875 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 64.56500244 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 69.06500244 152.12199402 Tm [(hepar)1(in)-1(-)1(binding)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 138.8500061 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 143.3500061 152.12199402 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 174.26600647 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 178.76600647 152.12199402 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 203.88499451 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 208.38499451 152.12199402 Tm [(1)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 213.66299438 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 218.16299438 152.12199402 Tm [(\(acidic)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 245.71699524 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 250.21699524 152.12199402 Tm [(fib)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(rob)1(last)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 29.79500008 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 34.29499817 167.72200012 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 65.21099854 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 69.71099854 167.72200012 Tm [(fa)1(c)-1(t)1(or\)-a)1(c)-1(t)1(ivated)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 140.88000488 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 145.38000488 167.72200012 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 179.86799622 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 184.36799622 167.72200012 Tm [(ki)-1(na)1(se)-1(.)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 213.62199402 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 218.12199402 167.72200012 Tm [(Two)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 236.10899353 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 240.60899353 167.72200012 Tm [(tr)1(ans)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 151.3999939 0.75 m 151.3999939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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