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23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(PLCG1)] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 114.00800323 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 116.38200378 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr7)1(83\))] TJ ET EMC /P <</Lang (zh-CN) /MCID 12 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 192.61500549 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 13 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 245.11500549 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 255.61500549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 15 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 16 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(P)1(L)-1(CG1)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 111.11599731 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 113.48999786 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr7)1(83\))] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 189.7230072 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 192.09700012 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 217.74699402 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 220.1210022 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 263.67999268 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 266.0539856 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 303.8500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLC1;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 86.56900024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 88.94300079 12.82499981 Tm [(NCK)1(AP)1(3;)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 126.40599823 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 128.77999878 12.82499981 Tm [(PLC-II;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 155.53199768 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 157.90600586 12.82499981 Tm [(PLC148;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 192.11799622 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 194.49200439 12.82499981 Tm [(PLCgamma1)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 247.02799988 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PLCG1)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 90.38300323 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 92.75700378 12.82499981 Tm [(\(Pho)-1(spho)-1(-Tyr7)1(83\))] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 168.99000549 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 94 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 95 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 96 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 97 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 144.2749939 0.75 l 144.2749939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 145.2749939 -0.25 l 145.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.0249939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 145.0249939 172.3500061 l h f* Q q 1 0 0 1 144.6499939 0 cm -0.625 -0.25 m 278.7749939 -0.25 l 278.7749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 197.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 202.2769928 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 216.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 220.77799988 11.72200012 Tm [(fo)1(rmatio)1(n)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 263.48001099 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(inosito)1(l)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 45.03499985 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 49.53499985 27.3220005 Tm [(1,4)-1(,)1(5)-1(-)1(trisp)1(hosp)1(hat)1(e)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 132.84700012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 137.34700012 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 153.62399292 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 158.12399292 27.3220005 Tm [(dia)1(c)-1(ylglyc)-1(erol)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 217.01100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 221.51100159 27.3220005 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 242.22200012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 246.72200012 27.3220005 Tm [(ph)1(os)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ph)1(atid)1(y)-1(linosit)1(ol)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 66.6210022 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 71.1210022 42.92200089 Tm [(4,5)-1(-)1(bisph)1(osph)1(ate.)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 148.11300659 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 152.61300659 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 169.875 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 174.375 42.92200089 Tm [(reaction)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 209.42100525 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 213.92100525 42.92200089 Tm [(uses)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 232.90499878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 237.40499878 42.92200089 Tm [(calc)-1(ium)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 270.17498779 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 9.14099979 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 13.64099979 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 18.61599922 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 23.11599922 58.52199936 Tm [(cofacto)1(r)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 58.47000122 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 62.97000122 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 79.24700165 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 83.74700165 58.52199936 Tm [(plays)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 105.79399872 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 110.29399872 58.52199936 Tm [(an)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 120.81500244 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 125.31500244 58.52199936 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 168.27600098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 172.77600098 58.52199936 Tm [(role)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 189.43600464 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 193.93600464 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 201.8769989 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 206.3769989 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 220.37800598 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 224.87800598 58.52199936 Tm [(intra)1(c)-1(ell)-1(ul)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ar)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 8.41100025 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 12.91100025 74.12200165 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 67.21900177 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 71.71900177 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 80.56099701 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 85.06099701 74.12200165 Tm [(rec)-1(ept)1(or-)1(m)-1(edia)1(ted)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 166.25900269 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 170.75900269 74.12200165 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 205.24699402 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 209.74699402 74.12200165 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 236.83500671 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 241.33500671 74.12200165 Tm [(activat)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ors)1(.)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 15.49100018 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 19.99099922 89.72200012 Tm [(For)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 33.93000031 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 38.43000031 89.72200012 Tm [(example,)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 76.92199707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 81.42199707 89.72200012 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 104.72200012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 109.22200012 89.72200012 Tm [(activat)1(ed)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 148.3730011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 152.8730011 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 163.38499451 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 167.88499451 89.72200012 Tm [(SRC,)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 187.14199829 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 191.64199829 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 205.64300537 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 210.14300537 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 247.6499939 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 252.1499939 89.72200012 Tm [(pro)1(t)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ein)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 13.04699993 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 17.54700089 105.3219986 Tm [(cause)-1(s)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 46.01900101 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 50.51900101 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 64.51999664 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 69.01999664 105.3219986 Tm [(Ras)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 84.03600311 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 88.53600311 105.3219986 Tm [(guanine)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 123.40699768 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 127.90699768 105.3219986 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 173.34599304 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 177.84599304 105.3219986 Tm [(exc)-1(h)1(ange)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 218.95199585 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 223.45199585 105.3219986 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 248.57099915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 253.07099915 105.3219986 Tm [(Ras)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(GR)1(P1)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 23.35300064 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 27.85300064 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 36.9280014 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 41.4280014 120.92199707 Tm [(tr)1(ansloc)-1(a)1(te)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 88.96800232 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 93.46800232 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 102.54299927 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 107.04299927 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 121.04399872 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 125.54399872 120.92199707 Tm [(Go)1(l)-1(g)1(i,)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 150.67199707 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 155.17199707 120.92199707 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 181.46899414 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 185.96899414 120.92199707 Tm [(it)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 191.71699524 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 196.21699524 120.92199707 Tm [(activat)1(es)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 233.7769928 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 238.2769928 120.92199707 Tm [(Ras)1(.)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 255.46000671 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 259.95999146 120.92199707 Tm [(Al)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(so,)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 12.0539999 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 16.55400085 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 32.00999832 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 36.50999832 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 67.81700134 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 72.31700134 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 86.99900055 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 91.49900055 136.52200317 Tm [(been)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 113.0059967 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 117.5059967 136.52200317 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 145.58700562 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 150.08700562 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 159.16200256 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 163.66200256 136.52200317 Tm [(be)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 174.51600647 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 179.01600647 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 183.99099731 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 188.49099731 136.52200317 Tm [(major)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 213.46099854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 217.96099854 136.52200317 Tm [(subst)1(rat)1(e)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 257.81100464 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 262.31100464 136.52200317 Tm [(f)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(or)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 9.15799999 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 13.65799999 152.12199402 Tm [(hepar)1(in)-1(-)1(binding)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 83.44300079 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 87.94300079 152.12199402 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 118.85900116 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 123.35900116 152.12199402 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 148.47799683 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 152.97799683 152.12199402 Tm [(1)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 158.2559967 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 162.7559967 152.12199402 Tm [(\(acidic)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 190.30999756 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 194.80999756 152.12199402 Tm [(fib)1(roblas)1(t)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 235.86799622 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 240.36799622 152.12199402 Tm [(gr)1(owt)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(h)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 5.54199982 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 10.04199982 167.72200012 Tm [(fa)1(c)-1(t)1(or\)-a)1(c)-1(t)1(ivated)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 81.21099854 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 85.71099854 167.72200012 Tm [(tyro)1(sin)-1(e)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 120.1989975 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 124.6989975 167.72200012 Tm [(ki)-1(na)1(se)-1(.)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 153.95300293 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 158.45300293 167.72200012 Tm [(Two)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 176.44000244 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 180.94000244 167.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 221.86199951 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 226.36199951 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 259.93200684 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 264.43200684 167.72200012 Tm [(e)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.6499939 0.75 m 144.6499939 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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