%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 138 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 97.68000031 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 147.35600281 23.67700005 Tm 0 Tr [(YPEL)1(5)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 207.17900085 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 317.61898804 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(YPEL)-1(5)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 114.65399933 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 167.15400696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.65400696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(YPEL5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.13700104 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.51100159 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.16099548 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.53500366 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.09399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.46800232 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.26400757 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CGI-127)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.04799652 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0011000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(YPEL)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.40399933 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0013000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001A000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B001C001D0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001E0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001D0026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 170.42500305 0.75 l 170.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 171.42500305 -0.25 l 171.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 171.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 171.17500305 156.75 l h f* Q q 1 0 0 1 170.80000305 0 cm -0.625 -0.25 m 252.625 -0.25 l 252.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(YP)1(EL5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.78300095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28300095 11.72200012 Tm [(\(yippee)-1(-)1(lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.34600067 11.72200012 Tm [(5\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.79599762 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.29599762 11.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.5530014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.0530014 11.72200012 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.87199402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.37199402 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.51300049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.01300049 11.72200012 Tm [(CGI-)1(1)-1(27,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.76499939 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.32600403 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.82600403 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.80099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.30099487 11.72200012 Tm [(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 27.3220005 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.84799957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.34799957 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.98799896 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.48799896 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.29499817 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.51699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.01699829 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.18800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.68800354 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.54200745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.04200745 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.41099548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.91099548 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.852005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.352005 27.3220005 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.76199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.26199341 27.3220005 Tm [(div)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ision-relat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.24599838 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.74599838 42.92200089 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.65299988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.15299988 42.92200089 Tm [(During)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.68899536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.18899536 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.59899902 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.09899902 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.39100647 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.89100647 42.92200089 Tm [(pro)1(gression,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.25799561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.75799561 42.92200089 Tm [(Y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(PEL5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.35099983 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.85099983 58.52199936 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.94300079 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.44300079 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.51799774 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.01799774 58.52199936 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.38999939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.88999939 58.52199936 Tm [(subce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.11199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.61199951 58.52199936 Tm [(regions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.90699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.40699768 58.52199936 Tm [(At)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.09300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.59300232 58.52199936 Tm [(inter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ph)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.53700066 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.03700066 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.87900162 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.37900162 74.12200165 Tm [(mito)1(sis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.17500305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.67500305 74.12200165 Tm [(YP)1(EL5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.45800018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.95800018 74.12200165 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.05000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.55000305 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.625 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.125 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.12600708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.62600708 74.12200165 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.44400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.94400024 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.22099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ce)-1(ntr)1(osome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.27099991 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.77099991 89.72200012 Tm [(th)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.31800079 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.81800079 89.72200012 Tm [(changes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.42199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.92199707 89.72200012 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.83599854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.33599854 89.72200012 Tm [(locatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.95599365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.45599365 89.72200012 Tm [(seque)-1(nt)1(ially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.96000671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.46000671 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.53500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 105.3219986 Tm [(spindle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.61399841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.11399841 105.3219986 Tm [(po)1(l)-1(es,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.41799927 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.91799927 105.3219986 Tm [(mito)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.08200073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.58200073 105.3219986 Tm [(spindle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.69500732 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.19500732 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.47200012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.97200012 105.3219986 Tm [(spindle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.08500671 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.58500671 105.3219986 Tm [(midz)1(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.27299976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.77299976 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.04999924 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.54999924 120.92199707 Tm [(finally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.13899994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.63899994 120.92199707 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.38700104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.88700104 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.44799805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.94799805 120.92199707 Tm [(tr)1(ansferred)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.38699341 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.88699341 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.96200562 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.46200562 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.46299744 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.96299744 120.92199707 Tm [(midb)1(ody)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.53799438 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.03799438 120.92199707 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.36599731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.86599731 120.92199707 Tm [(cy)-1(t)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ki)-1(nesis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.8409996 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.3409996 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.14799881 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.64799881 136.52200317 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.38899994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.88899994 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.73100281 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.23100281 136.52200317 Tm [(YP)1(EL5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.01400757 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.51400757 136.52200317 Tm [(during)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.95100403 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.45100403 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.86099243 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.36099243 136.52200317 Tm [(division)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.46099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.96099854 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.52200317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.62100029 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.12100029 152.12199402 Tm [(ye)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.34400177 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.84400177 152.12199402 Tm [(fully)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.06399918 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.56399918 152.12199402 Tm [(understo)1(od.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84100342 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 170.42500305 0.75 l 170.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 171.42500305 -0.25 l 171.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 171.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 171.17500305 16.35000038 l h f* Q q 1 0 0 1 170.80000305 0 cm -0.625 -0.25 m 252.625 -0.25 l 252.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 170.80000305 0.75 m 170.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 170.80000305 157.5 m 170.80000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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