%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.84300232 23.67700005 Tm 0 g [(RBB)1(P5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.7519989 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 154.7519989 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 331.45599365 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(RBBP)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.87000275 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.12000275 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.11999512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RBBP)1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.87000275 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.2440033 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.44599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.82000732 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.80000305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.17399597 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.647995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(re)1(ti)-1(nob)-1(lasto)-1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.39900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.772995 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.60099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.9750061 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.35699463 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.73100281 12.82499981 Tm [(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.86199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.23599243 12.82499981 Tm [(RBQ3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.84500122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.21899414 12.82499981 Tm [(SWD1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.16699219 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(332-5)1(38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(RBBP)1(5)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 396.30599976 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(retinobla)1(stoma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.32499695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.82499695 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.96900177 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.46900177 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.77600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.27600098 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.55400085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RBQ3)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.3010006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.8010006 11.72200012 Tm [(SWD)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.28699875 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q15)-1(29)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(53)-1(85)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 131.5249939 16.35000038 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 130.7749939 0.75 l 130.7749939 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 131.7749939 -0.25 l 131.7749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 131.5249939 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 131.5249939 109.94999695 l h f* Q q 1 0 0 1 131.1499939 0 cm -0.625 -0.25 m 296.0249939 -0.25 l 296.0249939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(ubiquito)1(usly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.0019989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.5019989 11.72200012 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.65600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.15600586 11.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.67399597 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.17399597 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.48098755 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.98098755 11.72200012 Tm [(wh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44999981 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.95000076 27.3220005 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.38999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.88999939 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.96499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.46499634 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.44000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.94000244 27.3220005 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.33399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.83399963 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.91099548 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.41099548 27.3220005 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.95300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.45300293 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.29499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.79499817 27.3220005 Tm [(WD)1(-repeat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.42700195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.92700195 27.3220005 Tm [(pro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(teins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.7329998 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.2329998 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.04000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.54000092 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.04699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.54699707 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85399628 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.35399628 42.92200089 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.96600342 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.46600342 42.92200089 Tm [(directly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.18600464 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.68600464 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.76100159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.26100159 42.92200089 Tm [(retinobla)1(stoma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.08599854 42.92200089 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ot)1(e)-1(in,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.28899956 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.78899956 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.88600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.38600159 58.52199936 Tm [(regulat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.22699738 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.72699738 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.13700104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.63700104 58.52199936 Tm [(pro)1(life)-1(r)1(ation.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.15299988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.65299988 58.52199936 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.6519928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.1519928 58.52199936 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.9960022 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.4960022 58.52199936 Tm [(preferentiall)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.65999985 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.15999985 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.1609993 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.6609993 74.12200165 Tm [(underpho)1(spho)1(ry)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.0269928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.5269928 74.12200165 Tm [(retinobla)1(stoma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.852005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.352005 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.65899658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.15899658 74.12200165 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.25299072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.75299072 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.7539978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(E1A-)1(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.59600067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.09600067 89.72200012 Tm [(po)1(c)-1(ke)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.43800354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.93800354 89.72200012 Tm [(B.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.75099945 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.25099945 89.72200012 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60099792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10099792 89.72200012 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.62399292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.12399292 89.72200012 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.20500183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.70500183 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.62701416 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.12701416 89.72200012 Tm [(var)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ants)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54000092 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76200104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.26200104 105.3219986 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.01200104 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.51200104 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.45200348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.95200348 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.25900269 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.75900269 105.3219986 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.91900635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.41900635 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.76600647 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.26600647 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.772995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.272995 105.3219986 Tm [(describe)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 0.75 m 131.1499939 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 17.10000038 m 131.1499939 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 33.45000076 m 131.1499939 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 49.80000305 m 131.1499939 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 66.15000153 m 131.1499939 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 82.5 m 131.1499939 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 98.84999847 m 131.1499939 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 131.1499939 115.19999695 m 131.1499939 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>