%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 107 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.91699982 23.67700005 Tm 0 g [(RASS)1(F9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.67900085 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 158.67900085 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.38299561 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(RASS)-1(F9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.8219986 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.82200623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RASS)-1(F9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.94599915 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.147995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.52200317 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.5019989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.87600708 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Ras)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.83699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.05500031 12.82499981 Tm [(asso)-1(c)1(i)-1(atio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.69500732 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.91299438 12.82499981 Tm [(\(Ral)-1(GDS/AF)-1(-6\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.82099915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.03900146 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.43600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.65400696 12.82499981 Tm [(famil)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.84799194 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.06600952 12.82499981 Tm [(\(N-te)1(rmin)-1(al\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.58099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.79901123 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 365.20001221 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 370.41799927 12.82499981 Tm [(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 378.54901123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.76699829 12.82499981 Tm [(PA)1(MCI;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(PCIP)1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.22400093 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.59799957 30.49699783 Tm [(P-CIP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.22700119 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(250)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(RASS)-1(F9)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 332.42800903 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 112.42500305 31.95000076 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ras)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01599979 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.51600075 11.72200012 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.44300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.94300079 11.72200012 Tm [(\(RalG)1(DS/AF-6\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.07299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.57299805 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.3999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.8999939 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.98199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.48199463 11.72200012 Tm [(\(N-t)1(e)-1(r)1(min)-1(a)1(l)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.34399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.84399414 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.10800171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(PA)1(MCI;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.46500015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.96500015 11.72200012 Tm [(PCIP1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.08800125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.58799744 11.72200012 Tm [(P-)1(CIP1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.43800354 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O75)-1(90)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(31)-1(58)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 112.42500305 16.35000038 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 111.67500305 0.75 l 111.67500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 112.67500305 -0.25 l 112.67500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 112.42500305 0.75 m 426.17498779 0.75 l 426.17498779 63.15000153 l 112.42500305 63.15000153 l h f* Q q 1 0 0 1 112.05000305 0 cm -0.625 -0.25 m 315.125 -0.25 l 315.125 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.19700623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.69700623 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.77200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.27200317 11.72200012 Tm [(perinuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.47601318 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.97601318 11.72200012 Tm [(en)-1(d)1(osom)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.43900013 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.93900013 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.20100021 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.70100021 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.00800323 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.50800323 27.3220005 Tm [(asso)1(c)-1(iat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.04499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.54499817 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.94099426 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.44099426 27.3220005 Tm [(pept)1(idylgly)-1(cine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.18299866 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.68299866 27.3220005 Tm [(alph)1(a-a)1(midat)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.79501343 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.29501343 27.3220005 Tm [(mo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nooxyg)1(e)-1(nase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.13700104 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.63700104 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.91400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.41400146 42.92200089 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.58499908 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.08499908 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.93900299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.43900299 42.92200089 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.80799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.30799866 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.70399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.20399475 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.20500183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.70500183 42.92200089 Tm [(tr)1(aff)1(i)-1(ck)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.71499634 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.55700684 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.05700684 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.51300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.01300049 42.92200089 Tm [(en)-1(z)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.53999996 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 58.52199936 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.93700027 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.43700027 58.52199936 Tm [(sec)-1(reto)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.04100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.54100037 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.6989975 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.1989975 58.52199936 Tm [(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.02000427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.52000427 58.52199936 Tm [(pa)1(thw)1(ays.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.31399536 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 0.75 m 112.05000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 32.70000076 m 112.05000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 49.05000305 m 112.05000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 65.40000153 m 112.05000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 81.75 m 112.05000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 98.09999847 m 112.05000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 114.44999695 m 112.05000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 112.05000305 130.80000305 m 112.05000305 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57501221 m 426.92498779 193.57501221 l S Q Q q 1 0 0 1 0 595.01800537 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>