%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 79.91699982 23.67700005 Tm 0 g [(RASS)1(F7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.67900085 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 158.67900085 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 335.38299561 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(RASS)-1(F7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.8219986 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.82200623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RASS)-1(F7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.94599915 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.147995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.52200317 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.5019989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.87600708 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.3500061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Ras)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.83699799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.75 12.82499981 Tm [(asso)-1(c)1(i)-1(atio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.38999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.30299377 12.82499981 Tm [(\(Ral)-1(GDS/AF)-1(-6\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.21099854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.12399292 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.52099609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.43400574 12.82499981 Tm [(famil)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.62799072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.54098511 12.82499981 Tm [(\(N-te)1(rmin)-1(al\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.05599976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 332.96899414 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 369.36999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.2829895 12.82499981 Tm [(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 383.41400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 389.32699585 12.82499981 Tm [(HRC1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(HRAS1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.27400017 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.64799881 30.49699783 Tm [(C11orf13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.93599701 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 260.37298584 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 288.31201172 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.0269928 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.40100098 12.55799961 Tm [(ter)1(min)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.55599976 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.92999268 12.55799961 Tm [(250)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.89500427 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26899719 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1499939 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.52400208 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02600098 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.3999939 12.55799961 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.14099121 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.51501465 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.48199463 12.55799961 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.85598755 12.55799961 Tm [(RASS)-1(F7)] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 332.42800903 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 317.25100708 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 345.19000244 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 373.1289978 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 401.06799316 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 119.17500305 31.95000076 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ras)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01599979 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.51600075 11.72200012 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.44300079 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.94300079 11.72200012 Tm [(\(RalG)1(DS/AF-6\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.07299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.57299805 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.3999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.8999939 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.98199463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.48199463 11.72200012 Tm [(\(N-t)1(e)-1(r)1(min)-1(a)1(l)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.34399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.84399414 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.10800171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 31.95000076 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 119.17500305 16.35000038 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(HRC1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.3010006 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.8010006 11.72200012 Tm [(HRAS1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.60900116 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.10900116 11.72200012 Tm [(C11)-1(or)1(f13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 48.29999924 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 119.17500305 16.35000038 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q02)-1(83)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 64.65000153 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 119.17500305 16.35000038 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(06)-1(92)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 119.17500305 16.35000038 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 119.17500305 16.35000038 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 119.17500305 16.35000038 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 118.42500305 0.75 l 118.42500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 119.42500305 -0.25 l 119.42500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.17500305 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 119.17500305 78.75 l h f* Q q 1 0 0 1 118.80000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RA)1(S)-1(SF7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.15599823 11.72200012 Tm [(\(Ras)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.1780014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.6780014 11.72200012 Tm [(asso)1(c)-1(iat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.60500336 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.10500336 11.72200012 Tm [(do)1(main-c)-1(o)1(ntaining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.57299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.07299805 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.38000488 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.88000488 11.72200012 Tm [(7\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.33000183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.83000183 11.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.08700562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.58700562 11.72200012 Tm [(desig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.73699951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.23699951 27.3220005 Tm [(HRAS1-related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.90100098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.40100098 27.3220005 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.91699982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.41700745 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.72399902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.22399902 27.3220005 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.66799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.16799927 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.72900391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.22900391 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.20399475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.70399475 27.3220005 Tm [(37)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.53700256 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.03700256 27.3220005 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.10699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.60699463 27.3220005 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.24700928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.74700928 27.3220005 Tm [(pro)1(tei)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.26799965 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.76799965 42.92200089 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.86000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.36000061 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.43499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.93499756 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.93599701 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.43599701 42.92200089 Tm [(ce)-1(ntr)1(osome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.70700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.20700073 42.92200089 Tm [(RA)1(S)-1(SF7,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.02900696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.52900696 42.92200089 Tm [(RA)1(S)-1(SF8,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.35099792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.85099792 42.92200089 Tm [(RA)1(S)-1(SF9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.50698853 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.00698853 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.28399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(RA)1(S)-1(SF10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.93399811 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.43399811 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.95199966 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.45199966 58.52199936 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.27600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.77600098 58.52199936 Tm [(evolutionary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.46000671 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.96000671 58.52199936 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.03700256 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.53700256 58.52199936 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.00999451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.50999451 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.73199463 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.23199463 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.75 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.25 58.52199936 Tm [(colle)-1(cti)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(vely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.98900032 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.48900032 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.30799866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.80799866 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.94900131 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.4489975 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.44999695 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.94999695 74.12200165 Tm [(N-t)1(e)-1(r)1(mi)-1(na)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.80000305 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.30000305 74.12200165 Tm [(RA)1(S)-1(SF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.67799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.17799377 74.12200165 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.42599487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.92599487 74.12200165 Tm [(Exp)1(re)-1(s)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.92199707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.42199707 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.36300659 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.86300659 74.12200165 Tm [(skin)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.03601074 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.53601074 74.12200165 Tm [(ne)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 0.75 m 118.80000305 31.95000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 32.70000076 m 118.80000305 48.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 49.05000305 m 118.80000305 64.65000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 65.40000153 m 118.80000305 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 81.75 m 118.80000305 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 98.09999847 m 118.80000305 113.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 114.44999695 m 118.80000305 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 118.80000305 130.80000305 m 118.80000305 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.80000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 32.32500076 m 426.17498779 32.32500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 48.67500305 m 426.17498779 48.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.02500153 m 426.17498779 65.02500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07499695 m 426.17498779 114.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 426.92498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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