%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 129 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.6289978 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 139.30499268 23.67700005 Tm 0 Tr [(RNF2)1(14)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 215.23100281 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 325.67098999 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(RN)1(F)-1(214)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 112.01899719 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.51899719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.01899719 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(RN)1(F)-1(2)1(14)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.0019989 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.37599945 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.02600098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.3999939 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.95899963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.33299255 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.1289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RN)1(F)-1(214)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26899719 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700110025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 379.85101318 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 407.79000854 cm q /GS2 gs 1 g 0.375 0.75 m 175.2250061 0.75 l 175.2250061 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 176.2250061 -0.25 l 176.2250061 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.9750061 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 175.9750061 141.1499939 l h f* Q q 1 0 0 1 175.6000061 0 cm -0.625 -0.25 m 247.82499695 -0.25 l 247.82499695 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RNF21)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.80699921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.30699921 11.72200012 Tm [(\(RING)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.84400177 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.34400177 11.72200012 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.70500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.20500183 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.51199341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.01199341 11.72200012 Tm [(21)-1(4\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.85099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.35099792 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.91200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.41200256 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.38699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.88699341 11.72200012 Tm [(70)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.72000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.22000122 11.72200012 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.28999329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.78999329 11.72200012 Tm [(ac)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(id)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.15200043 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.65200043 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.95899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.45899963 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.68099976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.18099976 27.3220005 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.39600372 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.89600372 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.26999664 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.77000427 27.3220005 Tm [(RING)1(-type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.16600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.66600037 27.3220005 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.54499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.04499817 27.3220005 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.40600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.90600586 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.36400032 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.86400032 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.3710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.8710022 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.38300323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.88300323 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.85800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.35800171 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.87400055 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.37400055 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.59599304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.09599304 42.92200089 Tm [(map)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.41799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.91799927 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.49299622 42.92200089 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.53399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.03399658 42.92200089 Tm [(chro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(moso)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.58200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.08200073 58.52199936 Tm [(11)-1(q)1(2)-1(3.3)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.56099701 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.06099701 58.52199936 Tm [(Chro)1(mosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.36300659 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.86300659 58.52199936 Tm [(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.41900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.91900635 58.52199936 Tm [(ho)1(u)-1(ses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.16700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.66700745 58.52199936 Tm [(over)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.65600586 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.15600586 58.52199936 Tm [(1,4)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 74.12200165 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.45999908 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.95999908 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.23699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.73699951 74.12200165 Tm [(comprises)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.42299652 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.92299652 74.12200165 Tm [(ne)-1(a)1(rly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.14500427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.64500427 74.12200165 Tm [(4%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.92999268 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.42999268 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.27200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.77200317 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.772995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.272995 74.12200165 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.31399536 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.81399536 74.12200165 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.97400093 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.47400093 89.72200012 Tm [(Jervel)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.20199966 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.70199966 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.97899628 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.47899628 89.72200012 Tm [(Lange-Nielse)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.40699768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.90699768 89.72200012 Tm [(syndrome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.0039978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.5039978 89.72200012 Tm [(Jacobs)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.84399414 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(syndrome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.09700012 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.59700012 105.3219986 Tm [(Niemann)-1(-)1(Pic)-1(k)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.1230011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.6230011 105.3219986 Tm [(disease,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.46099854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.96099854 105.3219986 Tm [(heredita)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.83200073 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.33200073 105.3219986 Tm [(angio)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ema)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.51399994 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.01399994 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.29100037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.79100037 120.92199707 Tm [(Smith-)1(Le)-1(mli-Op)1(itz)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.6989975 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.1989975 120.92199707 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.1289978 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.6289978 120.92199707 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.14700317 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.64700317 120.92199707 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.77400208 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.39599991 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.89599991 136.52200317 Tm [(defec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.01800156 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.51800156 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.45899963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.95899963 136.52200317 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.64099884 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.14099884 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.36299896 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.86299896 136.52200317 Tm [(map)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.18499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.68499756 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.75999451 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.25999451 136.52200317 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.05499268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.55499268 136.52200317 Tm [(11)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.2769928 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 175.2250061 0.75 l 175.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2250061 -0.25 l 176.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.9750061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.9750061 16.35000038 l h f* Q q 1 0 0 1 175.6000061 0 cm -0.625 -0.25 m 247.82499695 -0.25 l 247.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 175.2250061 0.75 l 175.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2250061 -0.25 l 176.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.9750061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.9750061 16.35000038 l h f* Q q 1 0 0 1 175.6000061 0 cm -0.625 -0.25 m 247.82499695 -0.25 l 247.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(RNF21)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.80699921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.8500061 cm q /GS2 gs 1 g 0.375 0.75 m 175.2250061 0.75 l 175.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2250061 -0.25 l 176.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.9750061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.9750061 16.35000038 l h f* Q q 1 0 0 1 175.6000061 0 cm -0.625 -0.25 m 247.82499695 -0.25 l 247.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(RNF21)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.15299988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 175.2250061 0.75 l 175.2250061 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 176.2250061 -0.25 l 176.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 175.9750061 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 175.9750061 16.35000038 l h f* Q q 1 0 0 1 175.6000061 0 cm -0.625 -0.25 m 247.82499695 -0.25 l 247.82499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ring)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.13400078 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.63400078 11.72200012 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.99499893 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.49499893 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.80200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.30200195 11.72200012 Tm [(21)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.13500214 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6000061 0.75 m 175.6000061 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6000061 141.8999939 m 175.6000061 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6000061 158.25 m 175.6000061 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6000061 174.6000061 m 175.6000061 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 175.6000061 190.95001221 m 175.6000061 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 206.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.2250061 m 422.42498779 174.2250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 190.57501221 m 422.42498779 190.57501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.92501831 m 423.17498779 206.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>