%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 138 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 93.58699799 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 143.26300049 23.67700005 Tm 0 Tr [(NR4A)1(3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 211.27200317 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 321.71200562 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 65.80999756 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 89.43499756 12.82499981 Tm [(NR)1(4A3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 121.25800323 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.75799561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.25799561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000D000A000B000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(R4A3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.93099976 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.30500031 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.95500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.32899475 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.88800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.26199341 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.05799866 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CHN;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.72799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.10199738 12.82499981 Tm [(TE)-1(C;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.7539978 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.12799835 12.82499981 Tm [(CS)-1(MF;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.16200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.53599548 12.82499981 Tm [(NOR1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.0980072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.47200012 12.82499981 Tm [(MIN)1(O)-1(R)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.52600098 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(4A3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.19799805 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001B001C001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001E0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00060007001D0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 24.53299904 m 42 24.53299904 l 42 42.54399872 l 0 42.54399872 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 38.11399841 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 38.11399841 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 144.67500305 0.75 l 144.67500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 145.67500305 -0.25 l 145.67500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 145.42500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 145.42500305 203.55000305 l h f* Q q 1 0 0 1 145.05000305 0 cm -0.625 -0.25 m 278.375 -0.25 l 278.375 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(st)1(e)-1(ro)1(i)-1(d)1(-t)1(hyroid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.07400513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.57400513 11.72200012 Tm [(ho)1(rmo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ne)-1(-)1(retinoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.25600052 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.75600052 27.3220005 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.1780014 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6780014 27.3220005 Tm [(superfa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.92900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.42900085 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.23599243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.73599243 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.24299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.74299622 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.05000305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.55000305 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.7210083 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.8409996 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.3409996 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.48200035 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.98200035 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.95700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.45700073 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.41100311 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.91100311 42.92200089 Tm [(activat)1(or.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.522995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.022995 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.83000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.33000183 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.63699341 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.13699341 42.92200089 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.17100525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.67100525 42.92200089 Tm [(efficie)-1(ntly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.48498535 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.9469986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.4469986 58.52199936 Tm [(NGFI-)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.4240036 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.9240036 58.52199936 Tm [(Response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.36000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.86000061 58.52199936 Tm [(Eleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.7480011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.2480011 58.52199936 Tm [(\(NBRE\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.21400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.71400452 58.52199936 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.06399536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.56399536 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.5039978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(versions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.26200104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.76200104 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.60400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.10400009 74.12200165 Tm [(extra)1(sk)-1(ele)-1(t)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.93299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.43299866 74.12200165 Tm [(myxoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.06500244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.56500244 74.12200165 Tm [(chondro)1(sarcomas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.18800354 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.68800354 74.12200165 Tm [(\(EMCs\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.62799072 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.12799072 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.04400063 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.54400063 89.72200012 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.54700089 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.04700089 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.88899994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.38899994 89.72200012 Tm [(rec)-1(ip)1(roc)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.6289978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.1289978 89.72200012 Tm [(tr)1(ansloc)-1(a)1(tions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.39100647 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.89100647 89.72200012 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.96299744 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.46299744 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.91900635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.41900635 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.93499756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.93600082 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.43600082 105.3219986 Tm [(gene)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.28399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.78399658 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.59100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.09100342 105.3219986 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.18699646 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.68699646 105.3219986 Tm [(breakpo)1(i)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.78199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.28199768 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.80000305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.30000305 105.3219986 Tm [(asso)1(c)-1(iat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.75899887 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.25899887 120.92199707 Tm [(Nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.54799652 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.04799652 120.92199707 Tm [(Rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.90899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.40899658 120.92199707 Tm [(Subfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.97900391 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.47900391 120.92199707 Tm [(4,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.92300415 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.42300415 120.92199707 Tm [(Gr)1(oup)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.56799316 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.06799316 120.92199707 Tm [(A,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.56700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.06700134 120.92199707 Tm [(Membe)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.69100952 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.19100952 120.92199707 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.46899414 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(\(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.27299976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.77300072 136.52200317 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.56800079 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.06800079 136.52200317 Tm [(9\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.35199738 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.85199738 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.1289978 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.6289978 136.52200317 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.56799316 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.06799316 136.52200317 Tm [(Ew)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.82000732 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.32000732 136.52200317 Tm [(Sarcome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.69999695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.19999695 136.52200317 Tm [(Bre)-1(a)1(k)-1(p)1(oin)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.02801514 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(Region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40099907 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.90100098 152.12199402 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.17900085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.67900085 152.12199402 Tm [(\(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.95199966 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.45199966 152.12199402 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.24700165 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.74700165 152.12199402 Tm [(22)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.4750061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.9750061 152.12199402 Tm [(RNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.5 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169 152.12199402 Tm [(Polymerase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.61000061 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.11000061 152.12199402 Tm [(II,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.56799316 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.06799316 152.12199402 Tm [(TATA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.05099487 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.55099487 152.12199402 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ox-)1(B)-1(inding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.21900177 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.71900177 167.72200012 Tm [(Pro)1(tein)-1(-)1(Asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.16299438 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.66299438 167.72200012 Tm [(Factor,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.61000061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.11000061 167.72200012 Tm [(68)-1(-)1(KD)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.12800598 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.62800598 167.72200012 Tm [(\(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.90100098 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.40100098 167.72200012 Tm [(chromos)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.53999996 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 183.32200623 Tm [(17)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.76800156 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.26800156 183.32200623 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.42599869 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.92599869 183.32200623 Tm [(Transcriptio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.31700134 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.81700134 183.32200623 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.93600464 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.43600464 183.32200623 Tm [(12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.99200439 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.49200439 183.32200623 Tm [(\(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.76499939 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.26499939 183.32200623 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.05999756 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.55999756 183.32200623 Tm [(15)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.28799438 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.78799438 183.32200623 Tm [(M)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(ultiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.93799973 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.43799973 198.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.36000061 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.86000061 198.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.43000031 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.93000031 198.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.27200317 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.77200317 198.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.71200562 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.21200562 198.92199707 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.37199402 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.87199402 198.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.21899414 198.92199707 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.05000305 0.75 m 145.05000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>