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[<0009000A000B000C000D>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(IL10)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 106.95300293 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 159.45300293 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 164.70300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(IL10)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 101.43699646 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 103.81099701 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 129.46099854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 131.83500671 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 175.39399719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 177.76800537 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 215.56399536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CS)-1(IF;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 83.70300293 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 86.07700348 12.82499981 Tm [(TGIF)-1(;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 108.09700012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 110.47100067 12.82499981 Tm [(GVHD)-1(S;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 143.68899536 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 146.06300354 12.82499981 Tm [(IL-)-1(1)1(0;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 169.79100037 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 172.16499329 12.82499981 Tm [(IL10A)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 195.94400024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0015000D>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000D>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IL10)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 80.70300293 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat,)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 150.21000671 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 152.58399963 12.82499981 Tm [(Ch)-1(icke)1(n,)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 188.68299866 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 191.05700684 12.82499981 Tm [(Pig,)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 206.45300293 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 208.82699585 12.82499981 Tm [(Rabb)-1(it,)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 239.13800049 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 241.51199341 12.82499981 Tm [(Sh)-1(e)1(ep,)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 270.43798828 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 272.81201172 12.82499981 Tm [(Gui)-1(nea)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 303.13299561 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 305.50698853 12.82499981 Tm [(Pig)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 318.2829895 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 87 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026000D>] TJ ET EMC /P <</MCID 88 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 92 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 98 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 99 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <</MCID 101 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 143.92500305 0.75 l 143.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 144.92500305 -0.25 l 144.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 102 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 103 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 144.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 144.67500305 172.3500061 l h f* Q q 1 0 0 1 144.30000305 0 cm -0.625 -0.25 m 279.125 -0.25 l 279.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 104 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 215.94000244 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 220.44000244 11.72200012 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 262.0249939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(prima)1(rily)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 37.97800064 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 42.47800064 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 52.99000168 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 57.49000168 27.3220005 Tm [(monocytes)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 104.81500244 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 109.31500244 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 125.59200287 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 130.09199524 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 139.16700745 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 143.66700745 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 148.64199829 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 153.14199829 27.3220005 Tm [(lesse)-1(r)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 177.51800537 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 182.01800537 27.3220005 Tm [(extent)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 209.04400635 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 213.54400635 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 224.05599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 228.55599976 27.3220005 Tm [(lymphocy)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tes.)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 14.79199982 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 19.29199982 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 36.55400085 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 41.05400085 42.92200089 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 77.35299683 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 81.85299683 42.92200089 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 96.53500366 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 101.03500366 42.92200089 Tm [(pleiotr)1(opic)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 147.56900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 152.06900024 42.92200089 Tm [(effec)-1(t)1(s)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 180.55400085 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 185.05400085 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 192.99499512 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 197.49499512 42.92200089 Tm [(immun)-1(o)1(re)-1(g)1(ulati)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(on)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 11.26799965 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 15.76799965 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 32.04499817 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 36.54499817 58.52199936 Tm [(inflammat)1(ion.)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 95.99900055 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 100.49900055 58.52199936 Tm [(It)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 106.4980011 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 110.9980011 58.52199936 Tm [(do)1(wn-regulat)1(e)-1(s)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 178.86300659 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 183.36300659 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 197.36399841 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 201.86399841 58.52199936 Tm [(expression)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 247.81799316 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 252.31799316 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 261.16000366 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 265.66000366 58.52199936 Tm [(T)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(h1)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 10.81900024 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 15.31900024 74.12200165 Tm [(cy)-1(t)1(oki)-1(nes,)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 57.95000076 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 62.45000076 74.12200165 Tm [(MHC)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 84.22499847 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 88.72499847 74.12200165 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 108.94000244 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 113.44000244 74.12200165 Tm [(II)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 118.73100281 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 123.23100281 74.12200165 Tm [(Ag)1(s,)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 141.65299988 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 146.15299988 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 162.42999268 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 166.92999268 74.12200165 Tm [(costimulat)1(ory)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 225.70199585 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 230.20199585 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(on)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 19.93400002 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 24.43400002 89.72200012 Tm [(macrop)1(hages.)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 84.97299957 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 89.47299957 89.72200012 Tm [(It)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 95.47200012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 99.97200012 89.72200012 Tm [(also)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 117.22899628 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 121.72899628 89.72200012 Tm [(en)-1(h)1(anc)-1(es)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 162.22900391 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 166.72900391 89.72200012 Tm [(B)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 172.37600708 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 176.87600708 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 191.28599548 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 195.78599548 89.72200012 Tm [(survival,)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 230.31399536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 234.81399536 89.72200012 Tm [(pro)1(life)-1(r)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(at)1(ion,)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 24.15699959 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 28.65699959 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 44.93399811 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 49.43399811 105.3219986 Tm [(antib)1(ody)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 87.69300079 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 92.19300079 105.3219986 Tm [(pro)1(duc)-1(t)1(ion.)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 142.09700012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 146.59700012 105.3219986 Tm [(This)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 163.85899353 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 168.35899353 105.3219986 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 204.65800476 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 209.15800476 105.3219986 Tm [(can)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 224.19200134 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 228.69200134 105.3219986 Tm [(block)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 251.97000122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 256.47000122 105.3219986 Tm [(NF)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(-kap)1(pa)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 30.23900032 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 34.73899841 120.92199707 Tm [(B)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 40.38600159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 44.88600159 120.92199707 Tm [(activit)1(y)-1(,)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 77.52400208 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 82.02400208 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 98.3010025 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 102.8010025 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 109.36199951 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 113.86199951 120.92199707 Tm [(involved)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 150.23100281 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 154.73100281 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 162.67199707 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 167.17199707 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 181.17300415 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 185.67300415 120.92199707 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 229.90400696 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 234.40400696 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 243.2460022 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 247.7460022 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 261.74700928 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 266.24700928 120.92199707 Tm [(J)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(AK)1(-STAT)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 37.7840004 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 42.2840004 136.52200317 Tm [(signaling)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 81.21499634 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 85.71499634 136.52200317 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 124.34300232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 128.84300232 136.52200317 Tm [(Knock)-1(o)1(u)-1(t)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 169.85699463 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 174.35699463 136.52200317 Tm [(st)1(u)-1(d)1(ie)-1(s)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 204.84599304 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 209.34599304 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 217.28700256 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 221.78700256 136.52200317 Tm [(mic)-1(e)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 242.23500061 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 246.73500061 136.52200317 Tm [(sugg)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ested)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 23.48900032 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 27.98900032 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 41.99000168 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 46.49000168 152.12199402 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 82.23100281 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 86.73100281 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 95.57299805 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 100.07299805 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 115.52899933 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 120.02899933 152.12199402 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 156.32800293 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 160.82800293 152.12199402 Tm [(as)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 169.96899414 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 174.46899414 152.12199402 Tm [(an)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 184.99000549 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 189.49000549 152.12199402 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 226.69799805 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 231.19799805 152.12199402 Tm [(immun)-1(o)1(r)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(egulato)1(r)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 36.29000092 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 40.79000092 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 48.73099899 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 53.23099899 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 67.23200226 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 71.73200226 167.72200012 Tm [(intestinal)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 110.96199799 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 115.46199799 167.72200012 Tm [(tr)1(ac)-1(t)1(.)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 137.25900269 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 141.75900269 167.72200012 Tm [(Mutat)1(ions)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 185.60800171 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 190.10800171 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 198.04899597 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 202.54899597 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 218.00500488 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 222.50500488 167.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 244.02099609 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 248.52099609 167.72200012 Tm [(are)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 262.03900146 167.72200012 Tm [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 144.30000305 0.75 m 144.30000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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