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ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 125.08799744 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 150.73800659 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 153.11199951 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 196.67100525 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 199.04499817 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 236.84100342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(PIR2)1(;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 84.90200043 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 87.27600098 12.82499981 Tm [(IBRDC2;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 121.52400208 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 123.89800262 12.82499981 Tm [(p53RF)-1(P)1(;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 158.81799316 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 161.19200134 12.82499981 Tm [(bA528A)1(10.3)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 213.44099426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(RN)1(F)-1(144)1(B)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 101.98000336 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <</MCID 76 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 147.4750061 0.75 l 147.4750061 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 148.4750061 -0.25 l 148.4750061 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 148.2250061 0.75 m 422.42501831 0.75 l 422.42501831 172.3500061 l 148.2250061 172.3500061 l h f* Q q 1 0 0 1 147.8500061 0 cm -0.625 -0.25 m 275.57501221 -0.25 l 275.57501221 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(p53)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 16.30400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 20.80400085 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 27.36499977 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 31.86499977 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 45.86600113 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 50.36600113 11.72200012 Tm [(most)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 72.04000092 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 76.54000092 11.72200012 Tm [(commonly)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 122.06700134 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 126.56700134 11.72200012 Tm [(mutat)1(ed)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 163.08999634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 167.58999634 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 189.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 193.60600281 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 201.54699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 206.04699707 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 236.08799744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 240.58799744 11.72200012 Tm [(canc)-1(e)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(r)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 3.43700004 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 7.9369998 27.3220005 Tm [(identified)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 48.86800003 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 53.36800003 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 62.44300079 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 66.94300079 27.3220005 Tm [(da)1(te.)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 88.30000305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 92.80000305 27.3220005 Tm [(Exp)1(re)-1(s)1(sion)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 138.59500122 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 143.09500122 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 151.93699646 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 156.43699646 27.3220005 Tm [(p53)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 172.74099731 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 177.24099731 27.3220005 Tm [(leads)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 199.63999939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 204.13999939 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 213.21499634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 217.71499634 27.3220005 Tm [(inhibitio)1(n)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 258.75100708 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 27.75200081 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 32.2519989 42.92200089 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 63.16799927 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 67.66799927 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 78.18000031 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 82.68000031 42.92200089 Tm [(preventing)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 129.397995 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 133.897995 42.92200089 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 185.09899902 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 189.59899902 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 198.44099426 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 202.94099426 42.92200089 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 221.51699829 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 226.01699829 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 246.72799683 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 251.22799683 42.92200089 Tm [(G1)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 263.19900513 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 9.07499981 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 13.57499981 58.52199936 Tm [(S)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 18.7689991 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 23.2689991 58.52199936 Tm [(ph)1(ase)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 48.80599976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 53.30599976 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 62.14799881 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 66.64800262 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 80.64900208 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 85.14900208 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 99.55899811 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 104.05899811 58.52199936 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 127.51699829 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 132.01699829 58.52199936 Tm [(Most)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 154.05099487 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 158.55099487 58.52199936 Tm [(impor)1(tant)1(l)-1(y,)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 210.83700562 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 215.33700562 58.52199936 Tm [(p53)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 231.64100647 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 236.14100647 58.52199936 Tm [(func)-1(t)1(io)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ns)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 9.71199989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 14.21199989 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 23.28700066 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 27.78700066 74.12200165 Tm [(cause)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 52.0929985 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 56.5929985 74.12200165 Tm [(arr)1(e)-1(st)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 81.06600189 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 85.56600189 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 94.40799713 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 98.90799713 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 117.48400116 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 121.98400116 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 129.92500305 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 134.42500305 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 148.42599487 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 152.92599487 74.12200165 Tm [(G1)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 164.89700317 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 169.39700317 74.12200165 Tm [(ph)1(ase)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 194.93400574 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 199.43400574 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 208.27600098 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 212.77600098 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 226.7769928 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 231.2769928 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 245.68699646 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 250.18699646 74.12200165 Tm [(cy)-1(cl)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 5.10599995 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 9.60599995 89.72200012 Tm [(fo)1(l)-1(lo)1(wing)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 49.76300049 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 54.26300049 89.72200012 Tm [(any)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 69.54699707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 74.04699707 89.72200012 Tm [(exposure)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 113.44000244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 117.94000244 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 126.78199768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 131.28199768 89.72200012 Tm [(ce)-1(lls)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 149.85800171 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 154.35800171 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 163.43299866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 167.93299866 89.72200012 Tm [(DNA)1(-da)1(maging)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 235.92500305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 240.42500305 89.72200012 Tm [(ag)1(e)-1(nt)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s.)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 6.33300018 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 10.83300018 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 26.63999939 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 31.13999939 105.3219986 Tm [(MDM2)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 60.86000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 65.36000061 105.3219986 Tm [(\(murine)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 98.82900238 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 103.32900238 105.3219986 Tm [(do)1(u)-1(b)1(le)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 133.60299683 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 138.10299683 105.3219986 Tm [(minu)-1(t)1(e-2)-1(\))] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 180.66000366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 185.16000366 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 216.46699524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 220.96699524 105.3219986 Tm [(wa)1(s)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 237.21400452 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 241.71400452 105.3219986 Tm [(initial)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ly)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 7.15899992 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 11.6590004 120.92199707 Tm [(identified)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 52.59000015 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 57.09000015 120.92199707 Tm [(as)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 66.23100281 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 70.73100281 120.92199707 Tm [(an)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 81.2519989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 85.7519989 120.92199707 Tm [(oncogene)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 128.77000427 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 133.27000427 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 141.21099854 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 145.71099854 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 150.68600464 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 155.18600464 120.92199707 Tm [(murine)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 185.64900208 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 190.14900208 120.92199707 Tm [(tr)1(ansfor)1(mation)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 254.32699585 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 258.82699585 120.92199707 Tm [(s)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ystem.)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 27.98900032 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 32.48899841 136.52200317 Tm [(MDM2)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 62.20899963 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 66.70899963 136.52200317 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 106.61599731 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 111.11599731 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 120.19100189 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 124.69100189 136.52200317 Tm [(bind)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 144.13699341 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 148.63699341 136.52200317 Tm [(p53)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 164.94099426 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 169.44099426 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 185.71800232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 190.21800232 136.52200317 Tm [(block)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 213.4960022 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 217.9960022 136.52200317 Tm [(p53)-1(-)1(me)-1(d)1(ia)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ted)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 14.2159996 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 18.7159996 152.12199402 Tm [(tr)1(ansactivat)1(ion)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 82.14199829 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 86.64199829 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 95.48400116 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 99.98400116 152.12199402 Tm [(cotra)1(n)-1(s)1(fe)-1(cted)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 158.65100098 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 163.15100098 152.12199402 Tm [(repor)1(ter)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 198.4960022 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 202.9960022 152.12199402 Tm [(constructs.)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 249.477005 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 253.977005 152.12199402 Tm [(Th)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(e)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 5.10599995 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 9.60599995 167.72200012 Tm [(MDM2)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 39.32600021 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 43.82600021 167.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 65.34200287 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 69.84200287 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 76.40299988 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 80.90299988 167.72200012 Tm [(amp)1(l)-1(if)1(ie)-1(d)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 121.22699738 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 125.72699738 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 133.66799927 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 138.16799927 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 143.14300537 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 147.64300537 167.72200012 Tm [(hig)1(h)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 166.87800598 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 171.37800598 167.72200012 Tm [(perce)-1(nta)1(ge)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 220.0249939 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 224.5249939 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 233.36700439 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 237.86700439 167.72200012 Tm [(huma)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 147.8500061 0.75 m 147.8500061 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17501831 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
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