%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 131 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 124.48600006 l -90 124.48600006 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 18 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q BT 1 0 0 -1 288 92.5 Tm /GS1 gs 0 g [( )] TJ ET q 1 0 0 1 0 102.5 cm Q Q EMC q 1 0 0 1 90 167.03599548 cm q 1 0 0 1 110 0 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(NR3C1)] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 115.9980011 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 226.43800354 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 237.43800354 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 -57.5 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -33.875 61.9640007 Tm [(NR)1(3C)-1(1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -2.52899933 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 49.97099304 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.22099304 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(R3C1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.45500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.82900238 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.47900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.85299683 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.41200256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.78599548 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.58200073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.13500214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.50900269 12.82499981 Tm [(GCR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.24199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.61599731 12.82499981 Tm [(GRL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.16500092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.53900146 12.82499981 Tm [(GCCR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.06100464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(3C)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.72100067 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.96800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34199524 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002200230024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 24.53299904 m 42 24.53299904 l 42 42.54399872 l 0 42.54399872 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 38.11399841 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAADA 10.5 Tf 1 0 0 -1 42 38.11399841 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 415.72900391 cm q 1 g 0.375 0.75 m 158.17500305 0.75 l 158.17500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 159.17500305 -0.25 l 159.17500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 158.92500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 158.92500305 156.75 l h f* Q q 1 0 0 1 158.55000305 0 cm -0.625 -0.25 m 264.875 -0.25 l 264.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(glucoc)-1(o)1(rticoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.43400574 11.72200012 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.52200317 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.6190033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.1190033 11.72200012 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.15299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.65299988 11.72200012 Tm [(fu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.07500076 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.57500076 27.3220005 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.93899918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.43899918 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.58000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.08000183 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.55500031 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.63900757 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.75799561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.25799561 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.47999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.97999573 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.59199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.09199524 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.16700745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.66700745 27.3220005 Tm [(gluco)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(corticoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.80599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.30599976 42.92200089 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.3030014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.8030014 42.92200089 Tm [(ele)-1(ments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.01499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.51499939 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.45599365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.95599365 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.95700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.45700073 42.92200089 Tm [(pro)1(moters)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.58000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.08000183 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.92199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.42199707 42.92200089 Tm [(glucoc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ort)1(ic)-1(o)1(i)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.29299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.79299927 58.52199936 Tm [(responsive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.90899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.40899658 58.52199936 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.09100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.59100342 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.66600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.16600037 58.52199936 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.55999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.05999756 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.89300537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.39300537 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.14399719 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.91799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.41799927 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.39300156 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.89300156 74.12200165 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.62000275 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.12000275 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.96199799 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46199799 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.6210022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.1210022 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.70500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.20500183 74.12200165 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.65699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.15699768 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.41900635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.91900635 74.12200165 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ce)-1(pt)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.87899971 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.37900162 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.93999863 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.43999863 89.72200012 Tm [(typically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.74099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.24099731 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.93099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.43099976 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.37200165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.87200165 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.8730011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.3730011 89.72200012 Tm [(cy)-1(t)1(oplas)1(m,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.60800171 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.10800171 89.72200012 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.75500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.25500488 89.72200012 Tm [(upon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.81700134 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.31700134 89.72200012 Tm [(lig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 105.3219986 Tm [(binding,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.0870018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.5870018 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.14800262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.64800262 105.3219986 Tm [(tr)1(anspor)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.24700165 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.74700165 105.3219986 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.76300049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.26300049 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.26400757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.76400757 105.3219986 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.74899292 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.24899292 105.3219986 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.2480011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.7480011 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.30900574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.80900574 105.3219986 Tm [(involv)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.30400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.80400085 120.92199707 Tm [(inflammat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.34999847 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.84999847 120.92199707 Tm [(responses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.17999268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.67999268 120.92199707 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.44200134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.94200134 120.92199707 Tm [(pro)1(life)-1(r)1(ation,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.45799255 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.95799255 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.23500061 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.32600021 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.8259964 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.76699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.26699829 136.52200317 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.24700165 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.74700165 136.52200317 Tm [(tiss)1(u)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.81199646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.31199646 136.52200317 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.16099548 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.66099548 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.602005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.102005 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.55799866 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.05799866 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.57400513 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.07400513 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.54300022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04300022 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.16999817 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.66999817 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.06600189 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56600189 152.12199402 Tm [(gene)-1(r)1(alize)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.57099915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.07099915 152.12199402 Tm [(glucoc)-1(o)1(rticoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.80999756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.30999756 152.12199402 Tm [(resista)1(n)-1(ce.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.24000549 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 158.17500305 0.75 l 158.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 159.17500305 -0.25 l 159.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 158.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 158.92500305 16.35000038 l h f* Q q 1 0 0 1 158.55000305 0 cm -0.625 -0.25 m 264.875 -0.25 l 264.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.03300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.55000305 0.75 m 158.55000305 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 158.55000305 157.5 m 158.55000305 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>