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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 124.48600006 l -90 124.48600006 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 18 1 cm q 270 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q BT 1 0 0 -1 288 92.5 Tm /GS1 gs 0 g [( )] TJ ET q 1 0 0 1 0 102.5 cm Q Q EMC q 1 0 0 1 90 167.03599548 cm /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 10.30900002 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 59.98500061 23.67700005 Tm 0 Tr [(NR3C1\()1(Phosp)1(ho)1(-)-1(S)1(e)-1(r226\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.55099487 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABC 22 Tf 1 0 0 -1 294.55099487 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABH 22 Tf 1 0 0 -1 404.99099731 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(NR)1(3C)-1(1)1(\()-1(P)1(h)-1(osph)-1(o-S)-1(e)1(r226)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.25799561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 186.50799561 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 239.00799561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.25799561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(N)1(R3C1\(Pho)-1(spho)-1(-Ser2)1(26\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.86700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.24099731 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.89100647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.26499939 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.82400513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.19799805 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.99398804 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(GR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.13500214 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.50900269 12.82499981 Tm [(GCR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.24199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.61599731 12.82499981 Tm [(GRL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.16500092 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.53900146 12.82499981 Tm [(GCCR;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.8710022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.24499512 12.82499981 Tm [(GCRS)-1(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.11000061 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0014>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0015000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001600170018>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(NR)1(3C)-1(1)1(\()-1(P)1(h)-1(osph)-1(o-S)-1(e)1(r226)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.13299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0020002100220023000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002400250026000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120027000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 24.53299904 m 42 24.53299904 l 42 42.54399872 l 0 42.54399872 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 38.11399841 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAADA 10.5 Tf 1 0 0 -1 42 38.11399841 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.375 0.75 l 422.375 156.75 l 155.17500305 156.75 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.57501221 -0.25 l 268.57501221 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(glucoc)-1(o)1(rticoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.43400574 11.72200012 Tm [(rec)-1(ept)1(or,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.52200317 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.6190033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.1190033 11.72200012 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.15299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.65299988 11.72200012 Tm [(fu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.07500076 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.57500076 27.3220005 Tm [(bo)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.93899918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.43899918 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.58000183 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.08000183 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.55500031 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.13900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.63900757 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.75799561 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.25799561 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.47999573 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.97999573 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.59199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.09199524 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.16700745 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.66700745 27.3220005 Tm [(glucoc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ort)1(ic)-1(o)1(i)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.29299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.79299927 42.92200089 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.79000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.29000092 42.92200089 Tm [(ele)-1(ments)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.5019989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.0019989 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.94299316 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.44299316 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.44400024 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.94400024 42.92200089 Tm [(pro)1(moters)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.06700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.56700134 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.40899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.90899658 42.92200089 Tm [(glucoc)-1(o)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ic)-1(o)1(id)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.78199959 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.28199959 58.52199936 Tm [(responsive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.39800262 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.89800262 58.52199936 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.58000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.08000183 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15499878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.65499878 58.52199936 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.04899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.54899597 58.52199936 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.38200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.88200378 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.63299561 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.13299561 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.41000366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.14099979 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64099979 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.61599922 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.11599922 74.12200165 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.8429985 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.34300232 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.18499756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.68499756 74.12200165 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.84400177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.34400177 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.92799377 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.42799377 74.12200165 Tm [(fa)1(c)-1(t)1(ors.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.88000488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.38000488 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.64199829 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.14199829 74.12200165 Tm [(rec)-1(ept)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.49800014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.99799919 89.72200012 Tm [(typically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.29899979 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.79899979 89.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.48899841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.98899841 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.93000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.43000031 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.43099976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.93099976 89.72200012 Tm [(cy)-1(t)1(oplas)1(m,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.16600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.66600037 89.72200012 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.31300354 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.81300354 89.72200012 Tm [(upon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.375 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.875 89.72200012 Tm [(ligand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.69900513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.19900513 89.72200012 Tm [(bi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nding,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.16699982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.66699982 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.22800064 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.72800064 105.3219986 Tm [(tr)1(anspor)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.32700348 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.82700348 105.3219986 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.84300232 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.34300232 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.34399414 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.84399414 105.3219986 Tm [(nuc)-1(leu)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.82899475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.32899475 105.3219986 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.32800293 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.82800293 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.38900757 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.88900757 105.3219986 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.25799561 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.75799561 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.69900513 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.19900513 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(flamma)1(tor)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.60499954 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.10499954 120.92199707 Tm [(responses,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.43499756 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.93499756 120.92199707 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.69700623 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.19700623 120.92199707 Tm [(pro)1(life)-1(r)1(ation,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.71299744 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.21299744 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.49000549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.99000549 120.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.98999977 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.48999977 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.43099976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.93099976 136.52200317 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.91100311 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.41100311 136.52200317 Tm [(tiss)1(u)-1(es.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.47599792 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.97599792 136.52200317 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.82499695 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.32499695 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.26600647 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.76600647 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.22200012 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.72200012 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.23800659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.73800659 136.52200317 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.2559967 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.7559967 136.52200317 Tm [(asso)1(c)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(at)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.19099998 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.69099998 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.0870018 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.5870018 152.12199402 Tm [(gene)-1(r)1(alize)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.59200287 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.09200287 152.12199402 Tm [(glucoc)-1(o)1(rticoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.83099365 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.33099365 152.12199402 Tm [(resista)1(n)-1(ce.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.26100159 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 154.42500305 0.75 l 154.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.42500305 -0.25 l 155.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADA 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 155.17500305 0.75 m 422.375 0.75 l 422.375 16.35000038 l 155.17500305 16.35000038 l h f* Q q 1 0 0 1 154.80000305 0 cm -0.625 -0.25 m 268.57501221 -0.25 l 268.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 0.75 m 154.80000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.80000305 157.5 m 154.80000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.75 0.75 m 422.75 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.125 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.375 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.125 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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