%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 154 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1499939 0 0 -90.05000305 0 90.05000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 49.67599869 23.67700005 Tm 0 Tr [(IL)1(9)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 81.4940033 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 191.93400574 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -88 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -88 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -35.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -25 61.9640007 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -1.375 61.9640007 Tm [(IL9)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 13.63200378 61.9640007 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 66.13200378 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.88200378 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(IL9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.11499786 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.48899841 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.13899994 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.51300049 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.07200623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.44599915 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.24200439 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(in)-1(te)1(rl)-1(e)1(uki)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.1780014 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.55200195 12.82499981 Tm [(9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.68299866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.05699921 12.82499981 Tm [(P4)1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.93400574 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.30799866 12.82499981 Tm [(HP4)1(0;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.727005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.10099792 12.82499981 Tm [(IL-)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.69700623 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(IL9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.38200378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001100120013000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 216.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 250.3730011 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 283.9119873 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 317.45098877 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 350.98999023 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0006000700130025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 384.5289917 m 416.75 384.5289917 l 416.75 415.72900391 l -1.45000005 415.72900391 l h f* Q q 1 0 0 1 0 384.5289917 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 415.72900391 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 443.66799927 cm q 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 125.17500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 125.17500305 156.75 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 298.625 -0.25 l 298.625 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.44000244 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.66200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.16200256 11.72200012 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.16900635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.66900635 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.80999756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.30999756 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.28500366 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.78500366 11.72200012 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(egulato)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.29000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.79000092 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.63199997 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.13199997 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.10699844 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.60699844 27.3220005 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.86000061 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.70200348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.20200348 27.3220005 Tm [(hemat)1(opoietic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.56500244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.06500244 27.3220005 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.80700684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.30700684 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.56900024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.06900024 27.3220005 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.36801147 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.86801147 27.3220005 Tm [(st)1(i)-1(mu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lat)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.99500084 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.49500084 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.90499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.40499878 42.92200089 Tm [(pro)1(life)-1(r)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.75499725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.25499725 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.53199768 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.03199768 42.92200089 Tm [(prevents)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.21899414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.71899414 42.92200089 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.88000488 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.38000488 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.3789978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.8789978 42.92200089 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.78601074 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.28601074 42.92200089 Tm [(th)1(ro)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ugh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.84399986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.34399986 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.34500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.84500122 58.52199936 Tm [(interle)-1(ukin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.56999969 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.06999969 58.52199936 Tm [(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.34799957 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.84799957 58.52199936 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.27000427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.77000427 58.52199936 Tm [(\(IL9)-1(R)1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.36599731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.86599731 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.96299744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.46299744 58.52199936 Tm [(activat)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.022995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.522995 58.52199936 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.4630127 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.9630127 58.52199936 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ignal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.06699944 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.56699944 74.12200165 Tm [(tr)1(ansduc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.40200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.90200043 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.17900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.67900085 74.12200165 Tm [(activat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.125 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.625 74.12200165 Tm [(\(STAT\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.48199463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.98199463 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.45500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.95500183 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.23199463 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.73199463 74.12200165 Tm [(th)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.33799744 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.83799744 74.12200165 Tm [(conn)-1(ect)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.12199974 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.62199974 89.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.92099762 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.42099762 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.4960022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.9960022 89.72200012 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.95999908 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.45999908 89.72200012 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.47599792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.97599792 89.72200012 Tm [(pro)1(c)-1(esses.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.272995 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.772995 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.58000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.08000183 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.59599304 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.0960083 89.72200012 Tm [(en)-1(cod)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.30300045 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80300045 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.25900078 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.75899887 105.3219986 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.05799866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.55799866 105.3219986 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.23999786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.73999786 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.24700165 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.74700165 105.3219986 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.67799377 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.17799377 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.31900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.81900024 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.79400635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.29400635 105.3219986 Tm [(candidat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.66999817 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.16999817 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.68600464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.18600464 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.46398926 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.96398926 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(th)1(ma.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.46899986 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.96899986 120.92199707 Tm [(Gene)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.68199921 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.18199921 120.92199707 Tm [(st)1(u)-1(d)1(ie)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.67099762 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.17099762 120.92199707 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.43900299 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.93900299 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.91400146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.41400146 120.92199707 Tm [(mouse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.38699341 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.88699341 120.92199707 Tm [(mod)1(e)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.30000305 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.80000305 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.64199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.14199829 120.92199707 Tm [(ast)1(hma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.58500671 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.08500671 120.92199707 Tm [(demonst)1(ra)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.2159996 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.7159996 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.93799973 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.43799973 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.89400101 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.39400101 136.52200317 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.69300079 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.19300079 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.7539978 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.2539978 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.22899628 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.72899628 136.52200317 Tm [(determining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.55999756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.05999756 136.52200317 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.17900085 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.67900085 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.61999512 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.11999512 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.1210022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.6210022 136.52200317 Tm [(pa)1(tho)1(gen)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(sis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.72700024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22700024 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.06900024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.56900024 152.12199402 Tm [(bro)1(nc)-1(hia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.83999634 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.33999634 152.12199402 Tm [(hyperrespo)1(n)-1(sivene)-1(s)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.20300293 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 124.42500305 0.75 l 124.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 125.42500305 -0.25 l 125.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 125.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 125.17500305 16.35000038 l h f* Q q 1 0 0 1 124.80000305 0 cm -0.625 -0.25 m 298.625 -0.25 l 298.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ELISA,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.37799835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.87799835 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50499725 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 0.75 m 124.80000305 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 124.80000305 157.5 m 124.80000305 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>