%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 147 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.25 0 0 -90.25 0 90.25 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 99.01799774 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 148.69400024 23.67700005 Tm 0 Tr [(UCN3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 205.84199524 23.67700005 Tm 2 Tr [<0005>-4<0006>-4<0007>-4<0004>-4<0008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 316.28201294 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 76.125 12.82499981 Tm [(UCN)1(3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.18499756 12.82499981 Tm [<00050006000700040008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.68499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.93499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(CN3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.16799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.54199982 12.82499981 Tm [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.19200134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.56599426 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.125 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.49899292 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.29499817 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000B000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(uroco)-1(r)1(ti)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.79499817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.16899872 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.30000305 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.6740036 12.82499981 Tm [(SC)-1(P)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.33099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.70500183 12.82499981 Tm [(SPC;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.73599243 12.82499981 Tm [(UCN)1(III)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.78599548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001000110012000F000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00130004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0014000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UCN)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.93499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0016000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 47.25 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69100189 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001E001F00200021000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0022>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0024000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0006000700120025000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(rabbi)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.65000153 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.02400208 12.82499981 Tm [(po)-1(lyclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.58299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 413.39001465 cm /P <> BDC BT 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 441.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 173.17500305 0.75 l 173.17500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 174.17500305 -0.25 l 174.17500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 173.92500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 173.92500305 172.3500061 l h f* Q q 1 0 0 1 173.55000305 0 cm -0.625 -0.25 m 249.875 -0.25 l 249.875 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(sauva)1(gine)-1(/c)-1(o)1(rtic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ot)1(ropin-)1(re)-1(leasing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.69799805 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.19799805 27.3220005 Tm [(fa)1(c)-1(t)1(or/urotensin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.97900391 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.47900391 27.3220005 Tm [(I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.125 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.625 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.70700073 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.20700073 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.04899597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.54899597 27.3220005 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.47400093 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.97400093 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.48100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.98100281 42.92200089 Tm [(prepr)1(opro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.48500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.98500061 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.54600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.04600525 42.92200089 Tm [(pro)1(teolytically)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.58200073 42.92200089 Tm [(pro)1(c)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(sed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02900028 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52899933 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.60400009 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.10400009 58.52199936 Tm [(gene)-1(r)1(ate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.48999786 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.98999786 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.99099731 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.49099731 58.52199936 Tm [(mat)1(u)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.34100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84100342 58.52199936 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.55499268 58.52199936 Tm [(ho)1(rmone)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.22799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.72799683 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.82499695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 74.12200165 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.60599899 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.10599899 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.61800003 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.11799622 74.12200165 Tm [(pa)1(n)-1(creatic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.67900085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.17900085 74.12200165 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.36099243 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.86099243 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.13800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.63800049 74.12200165 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.27200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.77200317 74.12200165 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.51400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.01400757 74.12200165 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.27600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.77600098 74.12200165 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ormo)1(n)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.96500015 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.46500015 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.02600098 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.52600098 89.72200012 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.04700089 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.54699707 89.72200012 Tm [(en)-1(d)1(ogenous)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.52100372 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.02100372 89.72200012 Tm [(ligand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.84500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.34500122 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.6230011 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.1230011 89.72200012 Tm [(corticot)1(ropin-re)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(leasing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.34000015 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.84000015 105.3219986 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.95899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.45899963 105.3219986 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.8809967 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.3809967 105.3219986 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.65899658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15899658 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.43600464 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.93600464 105.3219986 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.10699463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.60699463 105.3219986 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.28199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.78199768 105.3219986 Tm [(insul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.77099609 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.27099609 105.3219986 Tm [(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(cre)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.0720005 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.5719986 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.51300049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.01300049 120.92199707 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.01000214 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.51000214 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.58499908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.08499908 120.92199707 Tm [(plas)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.77600098 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.27600098 120.92199707 Tm [(glucose)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.48100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.98100281 120.92199707 Tm [(leve)-1(ls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.04100037 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.54100037 120.92199707 Tm [(Pat)1(ie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06200027 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56200027 136.52200317 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.53300095 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.03300095 136.52200317 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.31100082 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.81099701 136.52200317 Tm [(dia)1(be)-1(t)1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.41699982 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.91699982 136.52200317 Tm [(exhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.01800537 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.51800537 136.52200317 Tm [(reduc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.74000549 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.24000549 136.52200317 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.13299561 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.63299561 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.4750061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.9750061 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.97599792 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.50699997 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.00699997 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.31400299 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.81400299 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.75499725 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.25499725 152.12199402 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.43699646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.93699646 152.12199402 Tm [(ce)-1(lls.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.67900085 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.17900085 152.12199402 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.36999512 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.86999512 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.8710022 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.3710022 152.12199402 Tm [(bra)1(in)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.63800049 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.13800049 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.13900757 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.63900757 152.12199402 Tm [(en)-1(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ded)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.62000084 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.12000084 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.42699814 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.92699814 167.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.09799957 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.59799957 167.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.45200348 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.95200348 167.72200012 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.48699951 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.98699951 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.26499939 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.76499939 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.76600647 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.26600647 167.72200012 Tm [(effec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.75100708 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.25100708 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.09300232 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.59300232 167.72200012 Tm [(st)1(r)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 173.55000305 0.75 m 173.55000305 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 172.7250061 m 423.17498779 172.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>