%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 76 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.83000183 23.67700005 Tm 0 g [(FITC)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 131.83000183 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 291.9460144 23.67700005 Tm 0 Tr [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.47000122 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(FIT)-1(C)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 78.55999756 12.82499981 Tm [<0003000400050006000700080009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 154.68499756 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.62399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FIT)-1(C-con)-1(jugated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.1519928 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.52600098 12.82499981 Tm [(Goat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.23399353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.60800171 12.82499981 Tm [(anti)-1(-mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.06799316 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.44200134 12.82499981 Tm [(IgM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.00700378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150003000400160007>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 126 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0018000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<0019001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(FIT)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.18499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 273.63400269 cm q /GS2 gs 1 g 0.375 0.75 m 113.92500305 0.75 l 113.92500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 114.92500305 -0.25 l 114.92500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 114.67500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 114.67500305 156.75 l h f* Q q 1 0 0 1 114.30000305 0 cm -0.625 -0.25 m 309.125 -0.25 l 309.125 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.68799973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.18799973 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08399963 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.09100342 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48400116 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.05599976 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.78300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.28300476 27.3220005 Tm [(mg/mL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.36999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.86999512 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.81100464 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.31100464 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.33599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.83599854 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.3460083 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.8460083 27.3220005 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.69299984 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.19299984 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75399971 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25399971 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71499634 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.49299622 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.1969986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6969986 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.60499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.10499573 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.27099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.77099609 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.86599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.36599731 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.64300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.14300537 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.14401245 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.38299942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.88299942 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.40100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90100098 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.48600006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.98600006 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.4980011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.9980011 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.64500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.14500427 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.6499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.1499939 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.79100037 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.76600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.26600647 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.27799988 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.61999512 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.32400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.82400513 58.52199936 Tm [(ad)1(apt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.22599983 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.72599983 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.18500137 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.68500137 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.34899902 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.15599823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.65599823 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.75100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.25100708 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.46800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.96800232 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.6499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.1499939 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.33099365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.83099365 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.69699097 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.19699097 74.12200165 Tm [(func)-1(t)1(io)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ns,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.87800026 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37800026 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.45299911 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.95299911 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.39899826 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.89899826 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.97399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.47399902 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.97499847 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.72299957 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.2230072 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44500732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.94500732 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.96600342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.46600342 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.46699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.96699524 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.96400452 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.46400452 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.74099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.24099731 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.31600952 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.81600952 89.72200012 Tm [(rec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.72999954 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.22999954 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.38899994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.88899994 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.46499634 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.96499634 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.24199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.74199677 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.625 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.69999695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.19999695 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.5039978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.0039978 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.00500488 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.50500488 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.34899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.84899902 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65600586 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.15600586 105.3219986 Tm [(var)1(i)-1(a)1(bili)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ty)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.11699963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.61699963 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.45899963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.95999908 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.45999908 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.55500031 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.05500031 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.64099884 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.14099884 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.70200348 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.20200348 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.34500122 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.84500122 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.35699463 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.85699463 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.41400146 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.91400146 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.8039856 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.3039856 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.58099365 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.08099365 120.92199707 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.42200089 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.92200089 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.76399994 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.26399994 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.63700104 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.13700104 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.07800293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.57800293 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.09899902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.59899902 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.48300171 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.98300171 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.31100464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.81100464 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.78599548 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.28599548 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.81399536 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.31399536 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.60198975 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.10198975 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.86599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.36599731 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.92700195 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.64500046 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.14500046 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.22000122 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.72000122 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.5739975 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.0739975 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.18499756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.68499756 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.42100525 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q /GS2 gs 1 g 0.375 0.75 m 113.92500305 0.75 l 113.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 114.92500305 -0.25 l 114.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 56.50899887 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 114.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 114.67500305 16.35000038 l h f* Q q 1 0 0 1 114.30000305 0 cm -0.625 -0.25 m 309.125 -0.25 l 309.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(1/)-1(50)-1(-)1(2)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40599823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90599823 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.18399811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.68399811 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.35800171 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.85800171 11.72200012 Tm [(ap)1(plic)-1(at)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.62199402 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 114.30000305 0.75 m 114.30000305 156.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 114.30000305 157.5 m 114.30000305 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q q 1 0 0 1 0 447.48400879 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 475.42300415 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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