%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 77 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 269.45001221 0 0 -90.09999847 0 90.09999847 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 110 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [(Cy3)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 38.71500015 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 176.74299622 23.67700005 Tm 0 Tr [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.05700684 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 212.03100586 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -110 43.75799942 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -110 61.9640007 Tm /GS2 gs 0 g [<0009000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 -57.5 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 -52.25 61.9640007 Tm [(Cy3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 -33.95200348 61.9640007 Tm [<000300040005000600070008>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 31.67300415 61.9640007 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.88499451 61.9640007 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.25900269 61.9640007 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 82.6780014 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Cy3-conj)-1(ugate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63999939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.01400757 12.82499981 Tm [(Rabb)-1(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.70500183 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.07899475 12.82499981 Tm [(anti)-1(-rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.97399902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.3480072 12.82499981 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.55999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 116.21700287 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F001000110012000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140003000400150006>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 126 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 149.7559967 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0017000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00180019001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001B001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 183.29499817 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0003>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Cy3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.67299652 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 216.83399963 m 416.75 216.83399963 l 416.75 248.03399658 l -1.45000005 248.03399658 l h f* Q q 1 0 0 1 0 216.83399963 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 275.97299194 cm q 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 115.42500305 156.75 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunoglob)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.82900238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.32900238 11.72200012 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.52200317 11.72200012 Tm [(\(IgG)1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.6289978 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.1289978 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.19000244 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.56399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.06399536 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.90600586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.40600586 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.40699768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.90699768 11.72200012 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58099365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08099365 11.72200012 Tm [(ab)1(u)-1(nd)1(ant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.52600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02600098 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.49899292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.99899292 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(serum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.68799973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.18799973 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.58399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.08399963 27.3220005 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.59100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.09100342 27.3220005 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.98400116 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48400116 27.3220005 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.55599976 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.05599976 27.3220005 Tm [(8-17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.78300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.28300476 27.3220005 Tm [(mg/ml)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.14599609 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.64599609 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.58700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.08700562 27.3220005 Tm [(ad)1(u)-1(lt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.11199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.61199951 27.3220005 Tm [(bloo)1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.12200928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.62200928 27.3220005 Tm [(Ig)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(G)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.69299984 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.19299984 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.75399971 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.25399971 42.92200089 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.21499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.71499634 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.99299622 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.49299622 42.92200089 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.1969986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.6969986 42.92200089 Tm [(defense)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.60499573 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.10499573 42.92200089 Tm [(ag)1(ainst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.27099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.77099609 42.92200089 Tm [(mic)-1(r)1(oorg)1(anisms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.86599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.36599731 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.64300537 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.14300537 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.14401245 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.38299942 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.88299942 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.40100098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90100098 58.52199936 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.48600006 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.98600006 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.4980011 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.9980011 58.52199936 Tm [(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.64500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.14500427 58.52199936 Tm [(lymphocytes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.6499939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.1499939 58.52199936 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.79100037 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.76600647 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.26600647 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.27799988 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.11999512 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.61999512 58.52199936 Tm [(our)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.32400513 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.82400513 58.52199936 Tm [(ad)1(apt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.22599983 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.72599983 74.12200165 Tm [(immun)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.18500137 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.68500137 74.12200165 Tm [(response.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.84899902 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.34899902 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.15599823 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.65599823 74.12200165 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.75100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.25100708 74.12200165 Tm [(molec)-1(ule)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.46800232 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.96800232 74.12200165 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.6499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.1499939 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.33099365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.83099365 74.12200165 Tm [(separa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.69699097 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.19699097 74.12200165 Tm [(func)-1(t)1(io)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ns;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.87800026 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.37800026 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.45299911 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.95299911 89.72200012 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.39899826 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.89899826 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.97399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.47399902 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47499847 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.97499847 89.72200012 Tm [(pa)1(tho)1(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.72299957 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.2230072 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.44500732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.94500732 89.72200012 Tm [(eli)-1(cited)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.96600342 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.46600342 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.46699524 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.96699524 89.72200012 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.96400452 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.46400452 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.74099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.24099731 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.31600952 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.81600952 89.72200012 Tm [(rec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ruit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.72999954 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.22999954 105.3219986 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.38899994 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.88899994 105.3219986 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.46499634 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.96499634 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.24199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.74199677 105.3219986 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.125 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.625 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.69999695 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.19999695 105.3219986 Tm [(dest)1(roy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.5039978 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.0039978 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.00500488 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.50500488 105.3219986 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.34899902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.84899902 105.3219986 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.65600586 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.15600586 105.3219986 Tm [(var)1(i)-1(a)1(bil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.85400009 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.35400009 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.35499954 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.85499954 120.92199707 Tm [(IgG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.95000076 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.44999695 120.92199707 Tm [(po)1(ol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.03600311 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.53600311 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.09700012 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.59700012 120.92199707 Tm [(gene)-1(r)1(ated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.74000549 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.24000549 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.7519989 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.2519989 120.92199707 Tm [(soma)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.80900574 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.30900574 120.92199707 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.19900513 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.69900513 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.97601318 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.47601318 120.92199707 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 136.52200317 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.9640007 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.4640007 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.30599976 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.80599976 136.52200317 Tm [(speci)-1(f)1(ic)-1(it)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.17900085 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67900085 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.61999512 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.11999512 136.52200317 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.64100647 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.14100647 136.52200317 Tm [(individual)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.0249939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.5249939 136.52200317 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.85299683 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.35299683 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.32800293 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.82800293 136.52200317 Tm [(given)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.35600281 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.85600281 136.52200317 Tm [(time)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.14401245 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.64401245 136.52200317 Tm [(po)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.4079895 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.9079895 136.52200317 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 152.12199402 Tm [(estimat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.31100082 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.81100082 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.88600159 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.38600159 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.23999786 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.73999786 152.12199402 Tm [(10)-1(11)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.85099792 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.35099792 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.08700562 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 114.67500305 0.75 l 114.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 115.67500305 -0.25 l 115.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 115.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 115.42500305 16.35000038 l h f* Q q 1 0 0 1 115.05000305 0 cm -0.625 -0.25 m 308.375 -0.25 l 308.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(1/)-1(10)-1(0-100)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.73899841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.23899841 11.72200012 Tm [(Immunofluoresce)-1(nc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.84100342 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 0.75 m 115.05000305 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 115.05000305 157.5 m 115.05000305 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 173.4750061 m 423.17498779 173.4750061 l S Q Q q 1 0 0 1 0 449.82299805 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 477.76199341 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 505.70098877 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 533.64001465 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ 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